prof john carroll

Contacts
  • Prof
  • John
  • Carroll
  • Prof John Carroll
  • Tel: 44 207 679 7918
  • Ex: 33257
  • j.carroll@ucl.ac.uk
  • Website
  • https://iris.ucl.ac.uk/iris/extResource/image/01/JCARR13
  • 1996-01-15
Address
  • 792
  • Department of Cell and Developmental Biology
  • UCL, Gower St
  • London
  • WC1E 6BT
Joined UCL
  • 1996-01-15

Research Summary

How does an oocyte develop and then make the transition into a viable embryo? This is the basic question that research in our lab is aimed at understanding. To tackle this problem we use techniques in cell and molecular biology combined with live cell imaging to understand the processes that underlie oocyte and embryo development. Moving from the earliest stages to the latest, the specific problems we are working on in the laboratory include: 1. What determes the number of primordial follicles that form in the ovary? 2. The initiation of oocyte growth. 3. The control and role of mitochondrial fission, migration and metabolism during oocyte growth and maturation. 4. Control of the meiotic cell cycle and assymmetric cell division. 5. Role of signalling in cell proliferation and cell death in the preimplantation embryo. 6. Development of optimal culture conditions for oocytes and embryos.
Research Activities
  • 1026
  • Laboratory for oocyte and embryo development
  • 1738
  • Oocyte and Embryo Biology

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Additional Information
  • CMR
  • Calcium
  • Calcium imaging
  • Confocal microscopy
  • Embryo
  • Fertility
  • Fertilization
  • Fluorescence Resonance Energy Transfer (FRET)
  • Fluorescence microscopy techniques
  • Imaging
  • Microinjection
  • Mitochondria
  • Mitochondrial function
  • Mouse
  • Multi-photon imaging
  • Oocyte
  • Ovary
  • Protein transport/localisation
  • RNA interference
  • Reproductive biology
  • Signalling
  • Transgenic mice
  • Vesicle trafficking
  • cell signalling
  • fertility
  • imaging
  • mammalian oocytes and embryos
  • reproduction
Collaborators
  • DGFIT24
  • dr greg fitzharris