prof charles marson

Contacts
Appointment
  • ACAPRO
  • 1999-09-20
  • 1
  • Professor of Organic Chemistry
  • ME
  • Dept of Chemistry
  • MPS
  • Faculty of Maths & Physical Sciences
Joined UCL
  • 1999-09-20

Research Summary

Research in the Marson group involves both the uncovering of new synthetic organic methodology and the synthesis of novel organic compounds, either for use in chemical biology or medicinal chemistry. In the latter category are potent inhibitors of histone deacetylase (HDAC), as depicted in gold and magenta, docked into HDAC1 enzyme, and possessing in vitro IC50values down to 1 nM.
Research Activities
  • 4528
  • Asymmetric Fluorine Chemistry
  • 4526
  • Cancer Chemotherapy
  • 4525
  • Catalytic Asymmetric Synthesis
  • 1320
  • Mechanisms underlying loss of regenerative capabilities
  • 4527
  • Pyranone Chemistry
11 - 20 of 141 Publications« Previous Page: 2 of 14 Next »

Histone deacetylase inhibitors
Patent
Ref Type: Patent

A catalytic asymmetric protocol for the enantioselective synthesis of 3(2H)-furanones
Journal article
Ref Type: Journal article

Structure-activity relationships of aryloxyalkanoic acid hydroxyamides as potent inhibitors of histone deacetylase
Journal article
Ref Type: Journal article

Stereodefined and Structure-Activity Relationships of Aryloxyalkanoic acid Hydroxyamides as Potent Inhibitors of Histone Deacetylase
Journal article
Ref Type: Journal article

Aromatic Sulfide Inhibitors of Histone Deacetylase based on Arysulfinyl-2,4-dienoic Acid Hydroxyamides
Journal article
Ref Type: Journal article
Publisher: ACS

Synthesis of the penta-oxazole core of telomestatin in a convergent approach to poly-oxazole macrocycles
Journal article
Ref Type: Journal article
Publisher: ROYAL SOC CHEMISTRY

Syntheses of enantiopure 3,4-diamino-1-substituted pyrrolidines
Journal article
Ref Type: Journal article
Publisher: GEORG THIEME VERLAG KG

Asymmetric synthesis using catalysts containing multiple stereogenic centres and a trans-1,2-diaminocyclohexane core; reversal of predominant enantioselectivity upon N-alkylation.
Journal article
Ref Type: Journal article

Pharmaceutical agents
Patent
Ref Type: Patent

Enantioselective Syntheses of trans-3,4-Difluoropyrrolidines and Investigation of Their Applications in Catalytic Asymmetric Synthesis.
Journal article
Ref Type: Journal article
Publisher: ACS

Invalid Data from feed!

Additional Information
  • CMR
Collaborators
  • PFERR04
  • dr patrizia ferretti
  • PDECO50
  • dr paolo de coppi
  • MFLYT72
  • prof mark lythgoe
  • FAEDW40
  • dr frances edwards