prof charles marson

Contacts
Appointment
  • ACAPRO
  • 1999-09-20
  • 1
  • Professor of Organic Chemistry
  • ME
  • Dept of Chemistry
  • MPS
  • Faculty of Maths & Physical Sciences
Joined UCL
  • 1999-09-20

Research Summary

Research in the Marson group involves both the uncovering of new synthetic organic methodology and the synthesis of novel organic compounds, either for use in chemical biology or medicinal chemistry. In the latter category are potent inhibitors of histone deacetylase (HDAC), as depicted in gold and magenta, docked into HDAC1 enzyme, and possessing in vitro IC50values down to 1 nM.
Research Activities
  • 4528
  • Asymmetric Fluorine Chemistry
  • 4526
  • Cancer Chemotherapy
  • 4525
  • Catalytic Asymmetric Synthesis
  • 1320
  • Mechanisms underlying loss of regenerative capabilities
  • 4527
  • Pyranone Chemistry
1 - 10 of 141 Publications Page: 1 of 14 Next »

Multicomponent and sequential organocatalytic reactions: diversity with atom-economy and enantiocontrol
Journal article
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New and unusual scaffolds in medicinal chemistry
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Publisher: ROYAL SOC CHEMISTRY

Targeting the Histamine H-4 Receptor
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Effect of endogenous and synthetic antioxidants on hydrogen peroxide-induced guinea-pig colon contraction
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Publisher: BIRKHAUSER VERLAG AG

Effect of antioxidants on airway smooth muscle contraction: action of lipoic acid and some of its novel derivatives on guinea pig tracheal smooth muscle
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Publisher: BIRKHAUSER VERLAG AG

Effects of a selection of histone deacetylase inhibitors on the antigen- and agonist(s)-induced tracheal smooth muscle contraction
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Mode of Action of Histone Deacetylase Inhibitors on Mast Cell Histamine Release and Colon Muscle Contraction
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Histone Deacetylase Inhibitors: Design, Structure-Activity Relationships and Therapeutic Implications for Cancer
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Publisher: BENTHAM SCIENCE PUBL LTD

Effects of a selection of histone deacetylase inhibitors on mast cell activation and airway and colonic smooth muscle contraction
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Publisher: ELSEVIER SCIENCE BV

Thiostrepton selectively targets breast cancer cells through inhibition of forkhead box M1 expression
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Publisher: AMER ASSOC CANCER RESEARCH

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Additional Information
  • CMR
Collaborators
  • PFERR04
  • dr patrizia ferretti
  • PDECO50
  • dr paolo de coppi
  • MFLYT72
  • prof mark lythgoe
  • FAEDW40
  • dr frances edwards