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Professor Robin Ganellin FRS

Emeritus Professor of Medicinal Chemistry

Professor Robin Ganellin

Address: Department of Chemistry, UCL
Phone No: +44 (0)20 7679 4624
Fax No: +44 (0)20 7679 7463
Extension: 24624
Photo of Robin Ganellin


Research areas of interest include:

  • Synthesis
  • Drug Design
  • Structure-Activity Analysis

A full research profile is available here.


Summary

Professor Ganellin is no longer supervising postgraduate students or postdoctoral associates.

Our research is focused on the design of novel biologically active compounds as prototype drugs. In this we are involved in the synthesis of new compounds and in studying relationships between chemical structure and biological activity. We collaborate with biologists from other research groups who carry out the biological testing.

A full list of publications can be found here


Selected Publications

  1. N. Pelloux-Léon, A. Fkyerat, A. Piripitsi, W. Tertiuk, W. Schunack, H. Stark, M. Garbarg, X. Ligneau, J.-M. Arrang, J.-C. Schwartz and C. R. Ganellin. Meta-Substituted Aryl(thio)ethers as Potent Partial Agonists (or Antagonists) for the Histamine H3 Receptor Lacking a Nitrogen Atom in the Side Chain. J. Med. Chem. 2004, 47, 3264-3274.
  2. C.R. Ganellin, F. Leurquin, A. Piripitsi, J-M. Arrang, M. Garbarg, X. Ligneau, W. Schunack and J-C. Schwartz. Synthesis of Potent Non-imidazole Histamine H3-Receptor Antagonists. Arch. Pharm. Pharm. Med. Chem. 1998, 331, 395-404.
  3. C. R. Ganellin, P. B. Bishop, R. B. Bambal, S. M.T.Chan, B. Leblond, A. N.J. Moore, L. Zhao, P. Bourgeat, C. Rose, F. Vargas, J.-C. Schwartz. Inhibitors of Tripeptidyl Peptidase II. 3. Derivation of Butabindide by Successive Structure Optimizations Leading to a Potential General Approach to Designing Exopeptidase Inhibitors. J. Med. Chem. 2005, 48, 7333-7342.
  4. P.A. Zunszain, C. Federico, M. Sechi, S. Al-Damluji and C.R. Ganellin. Search for the Pharmacophore in Prazosin for Transport-P. Bioorg. Med. Chem. 2005, 13, 3681-3689.
  5. J. Fischer and C.R. Ganellin, Analogue-Based Drug Discovery. Wiley-VCH, Weinheim, 2006.