Dr Tom Sheppard

Organic Chemistry and Chemical Biology

Dr Tom Sheppard

Address: Department of Chemistry, UCL
Phone No: +44 (0)20 7679 2467
Fax No: +44 (0)20 7679 7463
Extension: 32467
Photo of Tom Sheppard

Research areas of interest include:

  • Catalysis
  • Applications of Boron compounds in Organic Synthesis
  • Strategically Important Hydration and Dehydration Reactions
  • Novel Ring Systems for Medicinal Chemistry
  • Multicomponent Reactions
  • Sustainable Chemistry
  • Drug Discovery


Tom Sheppard Research Image

Our research is focused on the development of new methods for organic synthesis. In all cases, the research projects seek to provide novel solutions to challenging chemical problems, which will facilitate the synthesis of small, highly functionalised organic molecules with potential applications in drug discovery or chemical biology. Particular areas of interest include transition-metal catalysis, organoboron chemistry, multicomponent reactions, sustainable chemistry, and the synthesis of novel ring systems for medicinal chemistry.

Research Profile

Selected Publications

1. C. K├Ârner, P. Starkov, T. D. Sheppard, J. Am. Chem. Soc. 2010, 132, 5968. doi:10.1021/ja102129c

2. M. N. Pennell, M. G. Unthank, P. Turner, T. D. Sheppard, J. Org. Chem. 2011, 76, 1479. doi:10.1021/jo102263t

3. M. N. Pennell, P. G. Turner, T. D. Sheppard, Chem. Eur. J. 2012, 18, 4748. doi:10.1002/chem.201102830

4. P. Starkov, F. Rota, J. M. D'Oyley, T. D. Sheppard, Adv. Synth. Catal. 2012, 354, 3217. doi:10.1002/adsc.201200491

5. S. S. Ramos, W. B. Motherwell, P. Almeida, L. Santos, T. D. Sheppard, M. C. Costa, Tetrahedron 2007, 63, 12608. doi:10.1016/j.tet.2007.10.016

6. S. E. Mann, A. E. Aliev, G. J. Tizzard, T. D. Sheppard, Organometallics 2011, 30, 1772. doi:10.1021/om2000585

7. R. W. Foster, C. J. Tame, H. C. Hailes, T. D. Sheppard, Adv. Synth. Catal. 2013, 355, 2353. doi:10.1002/adsc.201300055

8. P. Starkov, T. D. Sheppard, Org. Biomol. Chem. 2011, 9, 1320. doi:10.1039/C0OB01069C

9. R. M. Lanigan, P. Starkov, T. D. Sheppard, J. Org. Chem. 2013, 78, 4512. doi:10.1021/jo400509n

10. R. Waller, L. J. Diorazio, B. A. Taylor, W. B. Motherwell, T. D. Sheppard, Tetrahedron 2010, 66, 6496 doi:10.1016/j.tet.2010.05.083.

11. M. Bachman, S. E. Mann, T. D. Sheppard, Org. Biomol. Chem. 2012, 10, 162. doi:10.1039/C1OB06534C

12. R. M. Lanigan, T. D. Sheppard, Eur. J. Org. Chem. 2013, 7453. doi:10.1002/ejoc.201300573

13. S. Ishikawa, T. D. Sheppard, J. M. D'Oyley, A. Kamimura, W. B. Motherwell, Angew. Chem. Int. Ed. 2013, 52, 10060. doi:10.1002/anie.201304720

14. J. K. Gill, P. Kumar, T. D. Sheppard, E. Sher, N. S. Millar, Mol. Pharm. 2012, 81, 710. doi:10.1124/mol.111.076026

15. T. D. Sheppard, J. Chem. Res. 2011, 377. doi:10.3184/174751911X13096980701749

All Publications

  • 1995-1999 MSci Natural Sciences (Chemistry), University of Cambridge
  • 1999-2000 Research Scientist at GlaxoWellcome PLC, Stevenage and Cambridge
  • 2000-2004 PhD in Organic Chemistry with Professor Steven V. Ley, University of Cambridge
  • 2004-2007 Postdoctoral Researcher with Professor William B. Motherwell, University College London
  • 2007-2013 EPSRC Advanced Research Fellow and Lecturer in Organic Chemistry, University College London
  • 2013- Reader in Organic Chemistry, University College London