Professor Stephen Caddick

Research Overview

Stephen Caddick is a Professor in the Department of Chemistry and head of a laboratory working in the area of experimental organic chemistry and chemical biology. All members of the laboratory carry out research in order to gain a greater understanding of molecular interactions. This leads to the development of new reactions which are then used to generate chemical entities for use as probes of biological systems or as therapeutics. The laboratory has a wide range of research interests cutting across synthetic organic chemistry, organometallic chemistry, medicinal chemistry, chemical biology and drug discovery. The Caddick laboratory contributions include the development of new free-radical methods for the synthesis of functionalised aromatics and heterocycles; synthetic approaches to the enediyne anti-cancer agent Neocarzinostatin; the study of protein-ligand complexes; microwave assisted organic synthesis; dynamic resolution methods for natural and non-natural amino-acid synthesis; development of novel palladium catalysed protocols for organic synthesis; structural and mechanistic studies on organopalladium chemistry. Since arriving at UCL in 2003 the Caddick laboratory has focused on the development of novel methods for diversity oriented synthesis and this has led to innovative methods for the preparation of sulfonates and sulfonamides. These compounds have been applied in numerous areas including HIV, anti-bacterials, cardiovascular disease, sepsis, cancer and neuroscience. Most recently the Caddick laboratory has discovered an exciting new process which allows the formation of new chemical bonds using air as a reagent and generating only water as a by-product. The opportunities for developing truly sustainable and environmentally acceptable methods for manipulation of organic substances are being vigorously pursued. In a very productive collaborative venture the Caddick and Baker laboratories have discovered an innovative approach to the reversible chemical modification of proteins and now a series of new reagents and protocols are being developed for the selective covalent modification of proteins for biological and clinical studies.

A summary of current projects is available here.

Stephen Caddick has published more than 100 articles in international peer-review journals and has supervised more than 30 PhD students to completion. His laboratory is currently comprised 12 researchers.

Current funding from EPSRC, BBSRC, MRC, GSK, Eisai, Pfizer, and AstraZeneca is gratefully acknowledged.