Professor Stephen Caddick - Publications

    2014

    • Boyle, R. W., Bryden, F., Maruani, A., Caddick, S., Chudasama, V., Smith, M. E., Savoie, H. (2014). Regioselective and stoichiometrically controlled conjugation of photodynamic sensitizers to a HER2 targeting antibody fragment. Bioconjug Chem doi:10.1021/bc5000324. Author URL
    • Browne, L. E., Nunes, J. P. M., Sim, J., Chudasama, V., Bragg, L., Caddick, S., North, R. A. (2014). Optochemical Control of Engineered Trimeric P2X Receptors and Acid-Sensing Ion Channels. BIOPHYSICAL JOURNAL. ( Vol. 106 pp.641A-641A). Author URL
    • King, F. D., Aliev, A., Caddick, S., Tocher, D. (2014). Cyclisation reactions of N-cinnamoyl-9-aminoanthracenes. Org Biomol Chem doi:10.1039/c4ob00411f. Author URL
    • Maruani, A., Alom, S., Canavelli, P., Lee, M. T., Morgan, R. E., Chudasama, V., Caddick, S. (2014). A mild TCEP-based para-azidobenzyl cleavage strategy to transform reversible cysteine thiol labelling reagents into irreversible conjugates. Chem Commun (Camb) doi:10.1039/c4cc08515a. Author URL
    • Moody, P., Chudasama, V., Nathani, R. I., Maruani, A., Martin, S., Smith, M. E., Caddick, S. (2014). A rapid, site-selective and efficient route to the dual modification of DARPins. Chem Commun (Camb) doi:10.1039/c4cc00053f. Author URL
    • Schumacher, F. F., Nunes, J. P., Maruani, A., Chudasama, V., Smith, M. E., Chester, K. A., Baker, J. R., Caddick, S. (2014). Next generation maleimides enable the controlled assembly of antibody-drug conjugates via native disulfide bond bridging. Org Biomol Chem doi:10.1039/c4ob01550a. Author URL

    2013

    • Akhbar, A. R., Chudasama, V., Fitzmaurice, R. J., Powell, L., Caddick, S. (2013). Acyl hydrazides as acyl donors for the synthesis of diaryl and aryl alkyl ketones. Chem Commun (Camb) doi:10.1039/c3cc47967f. Author URL
    • Browne, L. E., Nunes, J. P., Sim, J. A., Chudasama, V., Bragg, L., Caddick, S., Alan North, R. (2013). Optical control of trimeric P2X receptors and acid-sensing ion channels. Proc Natl Acad Sci U S A doi:10.1073/pnas.1318582111. Author URL
    • Cal, P. M., Frade, R. F., Chudasama, V., Cordeiro, C., Caddick, S., Gois, P. M. (2013). Targeting cancer cells with folic acid-iminoboronate fluorescent conjugates. Chem Commun (Camb) doi:10.1039/c3cc47534d. Author URL
    • Castañeda, L., Maruani, A., Schumacher, F. F., Miranda, E., Chudasama, V., Chester, K. A., Baker, J. R., Smith, M. E., Caddick, S. (2013). Acid-cleavable thiomaleamic acid linker for homogeneous antibody-drug conjugation. Chem Commun (Camb) doi:10.1039/c3cc45220d. Author URL
    • Castañeda, L., Wright, Z. V. F., Marculescu, C., Tran, T. M., Chudasama, V., Maruani, A., Hull, E. A., Nunes, J. P. M., Fitzmaurice, R. J., Smith, M. E. B., Jones, L. H., Caddick, S., Baker, J. R. (2013). A mild synthesis of N-functionalised bromomaleimides, thiomaleimides and bromopyridazinediones. Tetrahedron Letters 54(27), 3493-3495
    • Chudasama, V., Akhbar, A. R., Bahou, K. A., Fitzmaurice, R. J., Caddick, S. (2013). Metal-free, hydroacylation of CC and NN bonds via aerobic C-H activation of aldehydes, and reaction of the products thereof. Org Biomol Chem doi:10.1039/c3ob41632a. Author URL
    • King, F. D., Aliev, A. E., Caddick, S., Tocher, D. A. (2013). The triflic acid-mediated cyclization reactions of N-cinnamoyl-1- naphthylamines. J Org Chem doi:10.1021/jo4018827. Author URL
    • King, F. D., Caddick, S. (2013). The triflic acid-mediated cyclisation of N-benzylcinnamanilides. Tetrahedron 69(40), 8592-8601 doi:10.1016/j.tet.2013.07.075.
    • Macmillan, D. (2013). Cysteine promoted C-terminal hydrazinolysis of native peptides and proteins. doi:10.1002/anie.201304997.
    • Moody, P., Burlina, F., Martin, S. R., Morgan, R. E., Offer, J., Smith, M. E., Molloy, J. E., Caddick, S. (2013). Evaluating the use of Apo-neocarzinostatin as a cell penetrating protein. Protein Eng Des Sel 26(4), 277-281 doi:10.1093/protein/gzs104. Author URL
    • Nathani, R. I., Chudasama, V., Ryan, C. P., Moody, P. R., Morgan, R. E., Fitzmaurice, R. J., Smith, M. E., Baker, J. R., Caddick, S. (2013). Reversible protein affinity-labelling using bromomaleimide-based reagents. Org Biomol Chem 11(15), 2408-2411 doi:10.1039/c3ob40239h. Author URL
    • Nathani, R. I., Moody, P., Chudasama, V., Smith, M. E. B., Fitzmaurice, R. J., Caddick, S. (2013). A novel approach to the site-selective dual labelling of a protein via chemoselective cysteine modification. Chemical Science 2013(4), 3455-3458 doi:10.1039/C3SC51333E. Author URL
    • Nunes, J. P. M., Afonso, C. A. M., Caddick, S. (2013). Synthesis of 2,4-bifunctionalised cyclopentenones from 2-furaldehyde. RSC Advances 3(35), 14975-14978 doi:10.1039/c3ra42663g.
    • Schumacher, F. F., Sanchania, V. A., Tolner, B., Wright, Z. V., Ryan, C. P., Smith, M. E., Ward, J. M., Caddick, S., Kay, C. W., Aeppli, G., Chester, K. A., Baker, J. R. (2013). Homogeneous antibody fragment conjugation by disulfide bridging introduces 'spinostics'. Sci Rep 3, 1525- doi:10.1038/srep01525. Author URL
    • Youziel, J., Akhbar, A. R., Aziz, Q., Smith, M. E., Caddick, S., Tinker, A., Baker, J. R. (2013). Bromo- and thiomaleimides as a new class of thiol-mediated fluorescence 'turn-on' reagents. Org Biomol Chem doi:10.1039/c3ob42141d. Author URL

    2012

    • Aliev, A. E., Mia, Z. A., Busson, M. J., Fitzmaurice, R. J., Caddick, S. (2012). Diastereomer configurations from joint experimental-computational analysis. J Org Chem 77(14), 6290-6295 doi:10.1021/jo301119h. Author URL
    • Jones, M. W., Strickland, R. A., Gibson, M. I., Haddleton, D. M., Schumacher, F. F., Caddick, S., Baker, J. R. (2012). Highly efficient disulfide bridging polymers for bioconjugates from radical-compatible dithiophenol maleimides. Chemical Communications 48(34), 4064-4066 doi:10.1039/c2cc30259d.
    • Jones, M. W., Strickland, R. A., Gibson, M. I., Haddleton, D. M., Schumacher, F. F., Caddick, S., Baker, J. R. (2012). Polymeric dibromomaleimides as extremely efficient disulfide bridging bioconjugation and pegylation agents. Journal of the American Chemical Society 134(3), 1847-1852 doi:10.1021/ja210335f.
    • King, F. D., Caddick, S. (2012). The acid-mediated ring opening reactions of α-aryl-lactams. ORGANIC & BIOMOLECULAR CHEMISTRY 10(16), 3244-3252 doi:10.1039/c2ob00012a. Author URL
    • King, F. D., Caddick, S. (2012). The acid-mediated ring opening/cyclisation reaction of N-benzyl-α- aryl-azetidinones. Tetrahedron 68(46), 9350-9354 doi:10.1016/j.tet.2012.09.046.
    • King, F. D., Caddick, S. (2012). The triflic acid-mediated cyclisation of N-benzyl-cinnamamides. Tetrahedron
    • Moody, P., Smith, M. E., Ryan, C. P., Chudasama, V., Baker, J. R., Molloy, J., Caddick, S. (2012). Bromomaleimide-Linked Bioconjugates Are Cleavable in Mammalian Cells. Chembiochem 13(1), 39-41 doi:10.1002/cbic.201100603. Author URL
    • Mooney, C. R., Sanz, M. E., McKay, A. R., Fitzmaurice, R. J., Aliev, A. E., Caddick, S., Fielding, H. H. (2012). Photodetachment spectra of deprotonated fluorescent protein chromophore anions. J Phys Chem A 116(30), 7943-7949 doi:10.1021/jp3058349. Author URL
    • Nathani, R., Moody, P., Smith, M. E. B., Fitzmaurice, R. J., Caddick, S. (2012). Bioconjugation of Green Fluorescent Protein via an Unexpectedly Stable Cyclic Sulfonium Intermediate. CHEMBIOCHEM 13(9), 1283-1285 doi:10.1002/cbic.201200231. Author URL

    2011

    • CADDICK, S., SMITH, M., BAKER, J. (2011). Functionalisation of solid substrates. Patent WO/2011/018613
    • CADDICK, S., SMITH, M., BAKER, J. (2011). Reversible covalent linkage of functional molecules. Patent WO/2011/018611
    • CADDICK, S., SMITH, M., BAKER, J. (2011). Thiol protecting group. Patent WO/2011/018612
    • Chudasama, V., Ahern, J. M., Dhokia, D. V., Fitzmaurice, R. J., Caddick, S. (2011). Functionalisation of aldehydes via aerobic hydroacylation of azodicarboxylates 'on' water. CHEM COMMUN 47(11), 3269-3271 doi:10.1039/c0cc04520a.
    • Chudasama, V., Ahern, J. M., Fitzmaurice, R. J., Caddick, S. (2011). Synthesis of gamma-ketophosphonates via aerobic hydroacylation of vinyl phosphoniates. TETRAHEDRON LETT 52(10), 1067-1069 doi:10.1016/j.tetlet.2010.12.083.
    • Chudasama, V., Smith, M. E., Schumacher, F. F., Papaioannou, D., Waksman, G., Baker, J. R., Caddick, S. (2011). Bromopyridazinedione-mediated protein and peptide bioconjugation. Chem Commun (Camb) 47(31), 8781-8783 doi:10.1039/c1cc12807h. Author URL
    • Hothersall, J. D., Black, J., Caddick, S., Vinter, J. G., Tinker, A., Baker, J. R. (2011). The design, synthesis and pharmacological characterization of novel beta(2)-adrenoceptor antagonists. BRIT J PHARMACOL 164(2), 317-331 doi:10.1111/j.1476-5381.2011.01269.x.
    • King, F. D., Aliev, A. E., Caddick, S., Tocher, D. A. (2011). A novel synthesis of (di)-benzazocinones via an endocyclic N-acyliminium ion cyclisation. Org Biomol Chem 9(5), 1547-1554 doi:10.1039/c0ob00559b. Author URL
    • King, F. D., Caddick, S. (2011). Novel acid-mediated reactions of phenyl-substituted lactams. TETRAHEDRON LETTERS 52(50), 6783-6784 doi:10.1016/j.tetlet.2011.10.032. Author URL
    • King, F. D., Caddick, S. (2011). Triflic acid-mediated phenylation of N-acylaminoalkyl diethylacetals and N-acyl-2-phenyl cyclic amides. ORG BIOMOL CHEM 9(11), 4361-4366 doi:10.1039/c0ob01149e.
    • Nunes, J. P. M., Veiros, L. F., Vaz, P. D., Afonso, C. A. M., Caddick, S. (2011). Asymmetric synthesis of trans-4,5-dioxygenated cyclopentenone derivatives by organocatalyzed rearrangement of pyranones and enzymatic dynamic kinetic resolution. TETRAHEDRON 67(15), 2779-2787 doi:10.1016/j.tet.2011.02.018.
    • Reddy, R. S., Rosa, J. N., Veiros, L. F., Caddick, S., Gois, P. M. P. (2011). NHC/Iron cooperative catalysis: aerobic oxidative esterification of aldehydes with phenols. ORG BIOMOL CHEM 9(9), 3126-3129 doi:10.1039/c1ob05151b.
    • Ryan, C., Lewis, A. K. D. K., Caddick, S., Kaltsoyannis, N. (2011). DFT studies of reductive elimination, C-H activation and beta-hydride elimination in alkyl and aryl palladium amine complexes. THEOR CHEM ACC 129(3-5), 303-312 doi:10.1007/s00214-010-0775-x.
    • RYAN, C., SMITH, M., SCHUMACHER, F., GROHMANN, D., PAPAIOANNOU, D., WAKSMAN, G., WERNER, F., BAKER, J., CADDICK, S. (2011). Tunable reagents for multi-functional bioconjugation: reversible or permanent chemical modification of proteins and peptides by control of maleimide hydrolysis. Chemical Communications 21(47) [Submitted]
    • Schumacher, F. F., Nobles, M., Ryan, C. P., Smith, M. E., Tinker, A., Caddick, S., Baker, J. R. (2011). In Situ Maleimide Bridging of Disulfides and a New Approach to Protein PEGylation. Bioconjug Chem 22(2), 132-136 doi:10.1021/bc1004685. Author URL

    2010

    • Baker, J. R., Hothersall, J. D., Fitzmaurice, R. J., Tucknott, M., Vinter, A., Tinker, A., Caddick, S. (2010). An efficient asymmetric synthesis of the potent beta-blocker ICI-118,551 allows the determination of enantiomer dependency on biological activity. Chem Commun (Camb) 46(22), 3953-3954 doi:10.1039/c0cc00142b.
    • Chudasama, V., Fitzmaurice, R. J., Ahern, J. M., Caddick, S. (2010). Dioxygen mediated hydroacylation of vinyl sulfonates and sulfones on water. CHEM COMMUN 46(1), 133-135 doi:10.1039/b914563j.
    • Chudasama, V., Fitzmaurice, R. J., Caddick, S. (2010). Hydroacylation of alpha,beta-unsaturated esters via aerobic C-H activation. NAT CHEM 2(7), 592-596 doi:10.1038/NCHEM.685.
    • Loh, B., Vozzolo, L., Mok, B. J., Lee, C. C., Fitzmaurice, R. J., Caddick, S., Fassati, A. (2010). Inhibition of HIV-1 Replication by Isoxazolidine and Isoxazole Sulfonamides. CHEM BIOL DRUG DES 75(5), 461-474 doi:10.1111/j.1747-0285.2010.00956.x.
    • Smith, M., Caddick, S., Baker, J. R., Waksman, G., Schumacher, F., Papaiannou, D., Tedaldi, L., Ryan, C. (2010). Protein Modification, Bioconjugation, and Disulfide Bridging Using Bromomaleimides. Journal of the American Chemical Society (132), 1960-1965 doi:10.1021/ja908610s.
    • Wu, L., Aliev, A. E., Caddick, S., Fitzmaurice, R. J., Tocher, D. A., King, F. D. (2010). A facile synthesis of dibenzopyrroloazepinones as tetracyclic allocolchicinoids-an unusual 1,2-phenyl shift. Chemical Communications 46, 318-320 doi:10.1039/b919114c. Author URL

    2009

    • Aliev, A. E., Sinclair, A. J., Zhou, S., Wilden, J. D., Caddick, S., Kullmann, D. M., Rusakov, D. A. (2009). Density functional and spectroscopic studies of nitrogen inversion in substituted dizocilpines. Journal of Physical Organic Chemistry 22(6), 607-612 doi:10.1002/poc.1490. Author URL
    • Caddick, S., Baker, J. R., Woolfson, F. W., Stoneman, R. G., Urbaniak, M. D. (2009). Protein-Small Molecule Interactions. Neocarzinostatin. Encyclopedia of Chemical Biology
    • Caddick, S., Fitzmaurice, R. (2009). Microwave enhanced synthesis. TETRAHEDRON 65(17), 3325-3355 doi:10.1016/j.tet.2009.01.105.
    • Cressina, E., Lloyd, A. J., De Pascale, G., Mok, B. J., Caddick, S., Roper, D. I., Dowson, C. G., Bugg, T. D. H. (2009). Inhibition of tRNA-dependent ligase MurM from Streptococcus pneumoniae by phosphonate and sulfonamide inhibitors. BIOORGAN MED CHEM 17(9), 3443-3455 doi:10.1016/j.bmc.2009.03.028.
    • Esposito, O., Roberts, D. E., Cloke, F. G. N., Caddick, S., Green, J. C., Hazari, N., Hitchcock, P. B. (2009). Carbon-Silicon Bond Activation by [Pd(ItBu)(2)] - the Molecular Structures of [Pd(Me3Si)(ItBu)(mu-I)](2) and [Pd(CH(2)ItBu)I-2]. EUR J INORG CHEM (13), 1844-1850 doi:10.1002/ejic.200801151.
    • Fitzmaurice, R. J., Ahern, J. M., Caddick, S. (2009). Synthesis of unsymmetrical ketones via simple C-H activation of aldehydes and concomitant hydroacylation of vinyl sulfonates. ORG BIOMOL CHEM 7(2), 235-237 doi:10.1039/b819235a.
    • King, F. D., Aliev, A. E., Caddick, S., Copley, R. C. B. (2009). An investigation into the electrophilic cyclisation of N-acyl-pyrrolidinium ions: a facile synthesis of pyrrolo-tetrahydroisoquinolones and pyrrolo-benzazepinones. Organic and Biomolecular Chemistry 7(17), 3561-3571 doi:10.1039/b907400g. Author URL
    • King, F. D., Aliev, A. E., Caddick, S., Tocher, D. A., Courtier-Murias, D. (2009). A facile synthesis of pyrrolo-(di)-benzazocinones via an intramolecular N-acyliminium ion cyclisation (vol 7, pg 167, 2009). Organic and Biomolecular Chemistry 7(24), 5271-5271 doi:10.1039/b922697b.
    • Lee, C. C., Fitzmaurice, R. J., Caddick, S. (2009). 3,5-Isoxazoles from alpha-bromo-pentafluorophenyl vinylsulfonates: Synthesis of sulfonates and sulfonamides. ORG BIOMOL CHEM 7(21), 4349-4351 doi:10.1039/b911098d.
    • Lewis, A. K. D., Caddick, S., Esposito, O., Cloke, F. G. N., Hitchcock, P. B. (2009). Synthetic and structural studies on amine coordination to Pd-N-heterocyclic carbene complexes. DALTON T (35), 7094-7098 doi:10.1039/b907102d.
    • Nunes, J. P. M., Afonso, C. A. M., Caddick, S. (2009). Asymmetric synthesis of functionalised cyclopentenones via organocatalysed rearrangement and enzymatic resolution of pyranones. TETRAHEDRON LETT 50(26), 3706-3708 doi:10.1016/j.tetlet.2009.03.212.

    2008

    • Cawley, M. J., Cloke, F. G. N., Fitzmaurice, R. J., Pearson, S. E., Scott, J. S. C., S, (2008). Development of a practical Buchwald-Hartwig amine arylation protocol using a conveniently prepared (NHC)Pd(R-allyl)Cl catalyst. Organic and Biomolecular Chemistry 6(15), 2820-2825
    • Esposito, O., Gois, P. M. P., Lewis, A. K. D. K., Caddick, S., Cloke, F. G. N., Hitchcock, P. B. (2008). Alkylpalladium N-Heterocyclic Carbene Complexes: Synthesis, Reactivity, and Catalytic Properties. ORGANOMETALLICS 27(24), 6411-6418 doi:10.1021/om800455h.
    • Trindale, A. F., Gois, P. M., Veiro, L. F., Andre, V., Duarte, M. T., Alfonso, C. A., Caddick, S., Cloke, F. G. (2008). Axial coordination of NHC ligands on dirhodium(II) complexes: Generation of a new family of catalysts. Journal of Organic Chemistry 73(11), 4076-4086 doi:10.1021/jo800087n.

    2007

    • Baker, J. R., Stoneman, R. G., Caddick, S., Woolfson, D. N., Muskett, F. W., Urbaniak, M. D. (2007). Protein-small molecule interactions in neocarzinostatin, the prototypical enediyne chromoprotein antibiotic. ChemBioChem 8(7), 705-717 doi:10.1002/cbic.200600534.
    • Baker, J. R., Thominet, O., Britton, H., Caddick, S. (2007). An efficient synthesis of epoxydiynes and a key fragment of neocarzinostatin chromophore. Organic Letters 9(1), 45-48 doi:10.1021/ol062461g.
    • Edetanlen-Elliot, O., Fitzmaurice, R. J., Wilden, J. D., Caddick, S. (2007). Tributyltin hydride and 1-ethylpiperidine hypophosphite mediated intermolecular radical additions to 2,4,6-trichlorophenyl vinyl sulfonate. Tetrahedron Letters 48(50), 8926-8929 doi:10.1016/j.tetlet.2007.10.030. Author URL
    • Esposito, O., De K Lewis, A. K., Hitchcock, P. B., Caddick, S., Cloke, F. G. N. (2007). Synthesis and reactivity of alkylpalladium N-heterocyclic carbene complexes. Chemical Communications , 1157-1159 doi:10.1039/b700671c. Author URL
    • Gois, P. M. P., Veiros, L. F., Alfonso, C. A. M., Caddick, S. C., F, G. N. (2007). Tuning the reactivity of dirhodium(II) complexes with axial N-heterocyclic carbene ligands: The arylation of aldehydes. Angewandte Chemie International Edition 46(30), 5750-5753 doi:10.1002/anie.200700924.
    • Morris, T., Sandham, D., Caddick, S. (2007). A microwave enhanced cross-metathesis approach to peptidomimetics. Organic and Biomolecular Chemistry 5(7), 1025-1027 doi:10.1039/b700804j.
    • Thominet, O., Baker, J. R., Britton, H., Etheridge, Z. C., Soscia, M. G., Caddick, S. (2007). Synthetic strategies to epoxydiynes and a key synthon of the neocarzinostatin chromophore. Organic and Biomolecular Chemistry 5(22), 3703-3712 doi:10.1039/b711196g. Author URL
    • Wilden, J. D., Geldeard, L., Lee, C. C., Judd, D. B., Caddick, S. (2007). Trichlorophenol (TCP) sulfonate esters: A selective alternative to pentafluorophenol (PFP) esters and sulfonyl chlorides for the preparation of sulfonamides. Chemical Communications (10), 1074-1076 doi:10.1039/b614604j.

    2006

    • Caddick, S. (2006). Wiki and other ways to share learning online. Nature 442(7104), 744-744 doi:10.1038/442744c.
    • Caddick, S., Muskett, F., Stoneman, R., Woolfson, D. N. (2006). Synthetic ligands for apo-neocarzinostatin. Journal of the American Chemical Society 128, 4204-4205 doi:10.1021/ja058419i.
    • Fitzmaurice, R. J., Caddick, S. (2006). Synthesis and small molecule interactions of apo-Neocarzinostatin. Abstracts of Papers of the American Chemical Society 231, 641-
    • Fitzmaurice, R. J., Etheridge, Z. C., Jurnel, E., Woolfson, D. N., Caddick, S. (2006). Microwave enhanced palladium catalysed coupling reactions: A diversity-oriented synthesis approach to functionalised flavones. Chemical Communications (46), 4814-4816 doi:10.1039/b610734f.
    • Lewis, A. K., Mok, B. J., Tocher, D. A., Wilden, J. D., Caddick, S. (2006). New synthesis of beta-sultams from pentafluorophenyl sulfonates. Organic Letters 8(24), 5513-5515 doi:10.1021/ol062164b.

    2005

    • Arentsen, K., Caddick, S., Cloke, F. G. N. (2005). On the efficiency of two-coordinate palladium(0) N-heterocyclic carbene complexes in amination and Suzuki-Miyaura reactions of aryl chlorides. TETRAHEDRON 61(41), 9710-9715 doi:10.1016/j.tet.2005.06.070.
    • Caddick, S., Wilden, J. D., Judd, D. B. (2005). Observations on the reactivity of pentafluorophenyl sulfonate esters. Chemical Communications , 2727-2728 doi:10.1039/b501212k.
    • Lerma, I. C., Cawley, M. J., Cloke, F. G. N., Arentsen, K., Scott, J. S., Pearson, S. E., Hayler, J., Caddick, S. (2005). Studies on Pd/imidazolium salt protocols for aminations of aryl bromides and iodides using lithium hexamethyldisilazide (LHMDS). Journal of Organometallic Chemistry 690(24-25), 5841-5848 doi:10.1016/j.jorganchem.2005.07.084.
    • Treweeke, N. R., Hitchcock, P. B., Pardoe, D. A., Caddick, S. (2005). Controlling diastereoselectivity in the reactions of enantiomerically pure alpha-bromoacyl-imidazolidinones with nitrogen nucleophiles: substitution reactions with retention or inversion of configuration. Chemical Communications , 1868-1870 doi:10.1039/b417954d.
    • Vallance, P., Bush, H. D., Mok, B. J., Hurtado-Guerrero, R., Gill, H., Rossiter, S., Wilden, J. D., Caddick, S. (2005). Inhibition of dimethylarginine dimethylaminohydrolase (DDAH) and arginine deiminase (ADI) by pentafluorophenyl (PFP) sulfonates. Chemical Communications (44), 5563-5565 doi:10.1039/b510709a.
    • Wilden, J. D., Judd, D. B., Caddick, S. (2005). Rate enhancement of PFP sulfonate ester aminolysis by chloride salts in organic and aqueous media. Tetrahedron Letters 46, 7637-7640 doi:10.1016/j.tetlet.2005.08.088.

    2004

    • Arentsen, K., Caddick, S., Geoffrey, F., Cloke, N., Hitchcock, P. B., Herring, A. (2004). Suzuki-Miyaura cross-coupling of aryl and alkyl halides using palladium/imidazolium salt protocols. Tetrahedron Letters 45, 3511-3515 doi:10.1016/j.tetlet.2004.02.134.
    • Caddick, S., Cloke, F. G. N., Hitchcock, P. B., Lewis, A. K. (2004). Unusual reactivity of a nickel N-heterocyclic carbene complex: tert-butyl group cleavage and silicone grease activation. Angewandte Chemie International Edition 43, 5824- doi:10.1002/anie.200460955.
    • Caddick, S., Etheridge, C. (2004). Kinetic resolution of 4,5-dihydroxylated cyclopentenones. Tetrahedron: Asymmetry 15, 503-507 doi:10.1016/j.tetasy.2003.11.024.
    • Caddick, S., Hamza, D., Judd, D. B., Reich, M. T., Wadman, S. N., Wilden, J. D. (2004). A novel route to functionalized PFP esters via rapid intermolecular radical addition to PFP acrylate mediated by ethylpiperidinium hypophosphite (EPHP). Tetrahedron Letters (45), 2363-2366 doi:10.1016/j.tetlet.2004.01.082.
    • Caddick, S., Wilden, J. D., Judd, D. B. (2004). Direct synthesis of sulfonamides and activated sulfonate esters from sulfonic acids. Journal of the American Chemical Society 126, 1024-1025 doi:10.1021/ja0397658.
    • Urbaniak, M. D., Bingham, J. P., Hartley, J. A., Woolfson, D. N., Caddick, S. (2004). Design and synthesis of a nitrogen mustard derivative stabilized by apo-neocarzinostatin. Journal of Medicinal Chemistry 47(19), 4710-4715 doi:10.1021/jm040790d.
    • Wilden, J. (2004). Synthesis of functionalised sulfonamides via microwave assisted displacement of PFP-sulfonates with amines. QSAR and Combinatorial Science 23(10), 902-905

    2003

    • Caddick, S., Bush, H. D. (2003). Synthesis of functionalized sulfonamides via 1,3-dipolar cycloaddition of pentafluorophenyl vinylsulfonate. ORG LETT 5(14), 2489-2492 doi:10.1021/ol0347388.
    • Caddick, S., Judd, D. B., Lewis, A. K. D., Reich, M. T., Williams, M. R. V. (2003). A generic approach for the catalytic reduction of nitriles. TETRAHEDRON 59(29), 5417-5423 doi:10.1016/S0040-4020(03)00858-5.
    • Caddick, S., Lewis, A. K., Sandham, D., Titcomb, L. R., McCarroll, A., Davies, B. P., Cloke, F. G. N. (2003). Studies on high-temperature amination reactions of aromatic chlorides using discrete Palladium-N-Heterocyclic Carbene (NHC) complexes and in situ palladium/imidazolium salt protocols. Molecular Diversity 7, 115-123
    • Lewis, A. K., Caddick, S., Cloke, F. G. N., Billingham, N. C., Hitchcock, P. B., Leonard, J. (2003). Synthetic, structural, and mechanistic studies on the oxidative addition of aromatic chlorides to a palladium (N-heterocyclic carbene) complex: Relevance to catalytic amination. Journal of the American Chemical Society 125(33), 10066-10073 doi:10.1021/ja035565k.
    • Urbaniak, M. D., Frost, L. M., Bingham, J. P., Kelland, L. R., Hartley, J. A., Woolfson, D. N., Caddick, S. (2003). Chemical synthesis and cytotoxicity of dihydroxylated cyclopentenone analogues of neocarzinostatin chromophore. Bioorganic and Medicinal Chemistry Letters 13(12), 2025-2027 doi:10.1016/S0960-894X(03)00328-7.

    2002

    • Caddick, S., Geoffrey, F., Cloke, N., Hitchcock P B, L., J, L., A K, M., D, T., L, R. (2002). The first example of simple oxidative addition of an aryl chloride to a discrete palladium N-heterocyclic carbene amination precatalyst. Organometallics 21, 4318-4319 doi:10.1021/om020552l.
    • Caddick, S., Hamza, D., Wadman, S. N., Wilden, J. D. (2002). Solid-phase intermolecular radical reactions 2: Synthesis of C-glycopeptide mimetics via a novel acrylate acceptor. Organic Letters 4(10), 1775-1777 doi:10.1021/ol025846h.
    • Caddick, S., Kofie, W. (2002). Observations on the intramolecular Heck reactions of aromatic chlorides using palladium/imidazolium salts. TETRAHEDRON LETTERS 43(51), 9347-9350
    • Caddick, S., Wilden, J. D., Bush, H. D., Wadman, S. N., Judd, D. B. (2002). A new route to sulfonamides via intermolecular radical addition to pentafluorophenyl vinylsulfonate and subsequent aminolysis. ORGANIC LETTERS 4(15), 2549-2551 doi:10.1021/ol026181m.
    • Urbaniak, M. D., Muskett, F. W., Finucane, M. D., Caddick, S., Woolfson, D. N. (2002). Solution structure of a novel chromoprotein derived from apo-Neocarzinostatin and a synthetic chromophore. BIOCHEMISTRY 41(39), 11731-11739 doi:10.1021/bi0262146.

    2001

    • Caddick, S. (2001). A practical method for the acylation of 2-imidazolidinone and 2-oxazolidinone chiral auxiliaries with 2-bromoacyl halides. Synthetic Communications 31(21), 3241-3254
    • Caddick, S., Afonso, C. A. M., Candeias, S. X., Hitchcock, P. B., Jenkins, K., Murtagh, L., Pardoe, D., Santos A G, T., N R, W., R, (2001). Synthesis of alpha-amino esters by dynamic kinetic resolution of alpha-haloacyl imidazolidinones. TETRAHEDRON 57(30), 6589-6605
    • Caddick, S., Cheung, S., Doyle, V. E., Frost, L. M., Soscia, M. G., Delisser, V. M., Williams, M. R. V., Etheridge, Z. C., Khan, S., hitchcock, P. B., Pairaudeau, G., Vile, S. (2001). Stereoselective synthesis of polyfunctionalised hydroxylated cyclopentanes from dihydroxylated 2-cyclopentenone derivatives. TETRAHEDRON 57(29), 6295-6303 doi:10.1016/S0040-4020(01)00590-7.
    • Caddick, S., Cloke, F. G. N., Clentsmith, G. K. B., Hitchcock, P. B., McKerrecher, D., Titcomb, L. R., Williams, M. R. V. (2001). An improved synthesis of bis(1,3-di-N-tert-butylimidazol-2-ylidene)palladium(0) and its use in C-C and C-N coupling reactions. J ORGANOMET CHEM 617(1), 635-639
    • Caddick, S., McCarroll, A. J., Sandham, D. A. (2001). A convenient and practical method for the selective benzoylation of primary hydroxyl groups using microwave heating. TETRAHEDRON 57(29), 6305-6310 doi:10.1016/S0040-4020(01)00592-0.
    • Caddick, S., Parr, N. J., Pritchard, M. C. (2001). Preparation of alpha-amino-carboxylic acid derivatives via diastereoselective reactions of glycine enolate equivalents. TETRAHEDRON 57(30), 6615-6626
    • Santos, A. G., Candeias, S. X., Afonso, C. A. M., Jenkins, K., Caddick, S., Treweeke, N. R., Pardoe, D. (2001). Rationalising diastereoselection in the dynamic kinetic resolution of alpha-haloacyl imidazolidinones: a theoretical approach. TETRAHEDRON 57(30), 6607-6614
    • Titcomb, L. R., Caddick, S., Cloke, F. G. N., Wilson, D. J., McKerrecher, D. (2001). Unexpected reactivity of two-coordinate palladium-carbene complexes; synthetic and catalytic implications. Chemical Communications 15, 1388-1389 doi:10.1039/b104297c.

    2000

    • Caddick, S., Cheung, S., Frost, L. M., Khan, S., Pairaudeau, G. (2000). Synthesis of functionalised cyclopentenones via rearrangement of pyranones. TETRAHEDRON LETTERS 41(35), 6879-6882 doi:10.1016/S0040-4039(00)01043-1.
    • Caddick, S., Haynes, A. K. D., Judd, D. B., Williams, M. R. V. (2000). Convenient synthesis of protected primary amines from nitriles. TETRAHEDRON LETTERS 41(18), 3513-3516 doi:10.1016/S0040-4039(00)00410-X.
    • Caddick, S., Khan, S., Frost, L. M., Smith, N. J., Cheung, S., Pairaudeau, G. (2000). Studies toward the synthesis of natural and unnatural dienediynes. Part 2: A practical approach to functionalised cyclopentenones. TETRAHEDRON 56(45), 8953-8958 doi:10.1016/S0040-4020(00)00846-2.
    • Caddick, S., Murtagh, L., Weaving, R. (2000). Potassium ferrate on wet alumina: Preparation and reactivity. TETRAHEDRON 56(47), 9365-9373 doi:10.1016/S0040-4020(00)00907-8.
    • Caddick, S., Parr, N. J., Pritchard, M. C. (2000). syn-selective boron mediated aldol condensations for the asymmetric synthesis of beta-hydroxy-alpha-amino acids. TETRAHEDRON LETT 41(31), 5963-5966
    • Caddick, S., Shering, C. L., Wadman, S. N. (2000). Radical catalysed cyclisations onto sulfone-substituted indoles. TETRAHEDRON 56(3), 465-473 doi:10.1016/S0040-4020(99)01027-3.

    1999

    • Caddick, S. D., V M, D., V E, K., S, A., A G, V., S, (1999). Studies toward the synthesis of natural and unnatural dienediynes 1. Approaches to a functionalised bicyclic ring system. TETRAHEDRON 55(9), 2737-2754 doi:10.1016/S0040-4020(99)00045-9.
    • Caddick, S. M., L, W., R, (1999). A novel oxidative cleavage reaction of propargyl alcohol derivatives using K2FeO4-Al2O3. TETRAHEDRON LETTERS 40(18), 3655-3656 doi:10.1016/S0040-4039(99)00526-2.
    • Caddick, S., Hamza, D., Wadman, S. N. (1999). Solid-phase intermolecular radical reactions 1. Sulfonyl radical addition to isolated alkenes and alkynes. TETRAHEDRON LETTERS 40(40), 7285-7288 doi:10.1016/S0040-4039(99)01525-7.

    1998

    • Caddick, S., Jenkins, K., Treweeke, N., Candeias, S. X., Afonso, C. A. M. (1998). Rationalising diastereoselection in the dynamic kinetic resolution of alpha-haloacyl imidazolidinones. TETRAHEDRON LETTERS 39(15), 2203-2206 doi:10.1016/S0040-4039(98)00175-0.

    1997

    • Caddick, S. S., C L, W., S, N. (1997). Application of a radical catalysed isomerisation reaction to the synthesis of fused [1,2-a]indoles. TETRAHEDRON LETTERS 38(35), 6249-6250
    • Caddick, S., Delisser, V. M. (1997). Stereoselective synthesis of a functionalised bicyclic core of neocarzinostatin and kedarcidin chromophores. TETRAHEDRON LETTERS 38(13), 2355-2358 doi:10.1016/S0040-4039(97)00347-X.
    • Caddick, S., Khan, S., Smith, N. J., Barr, D. M., Delisser, V. M. (1997). Synthesis of a dihydroxylated dienediyne analogue related to neocarzinostatin chromophore. TETRAHEDRON LETTERS 38(28), 5035-5036 doi:10.1016/S0040-4039(97)01063-0.
    • Caddick, S., Shanmugathasan, S., Brasseur, D., Delisser, V. M. (1997). Asymmetric dihydroxylation of homoallylic enynols. TETRAHEDRON LETTERS 38(32), 5735-5736 doi:10.1016/S0040-4039(97)01259-8.
    • Caddick, S., Shering, C. L., Wadman, S. N. (1997). Synthesis of p-tolylsulfonyl-substituted dienes via radical cyclization of diynes. Chemical Communications (2), 171-172
    • Nicholls, A. W., Lindon, J. C., Caddick, S. F., R D, W., I, D. (1997). NMR spectroscopic studies on the metabolism and futile deacetylation of phenacetin in the rat. XENIOBIOTICA 27(11), 1175-1186 doi:10.1080/004982597239930.
    • Shering, C. L., Caddick, S., Wadman, S. N. (1997). Synthesis of 4-(methyl)phenylsulfonyl-substituted dienes via radical cyclization of diynes. Abstracts of Papers of the American Chemical Society 213(2), 641-

    1996

    • Aboutayab, K., Caddick, S., Jenkins, K., Joshi, S., Khan, S. (1996). Preparation of organostannanes by intermolecular radical substitution reactions. TETRAHEDRON 52(34), 11329-11340
    • Caddick, S., Aboutayab, K., Jenkins, K., West, R. I. (1996). Intramolecular radical substitution reactions: A novel approach to fused [1,2-a]indoles. J CHEM SOC PERK T 1 (7), 675-682
    • Caddick, S., Gazzard, L., Motherwell, W. B., Wilkinson, J. A. (1996). Preparation of 1-fluoroglycosides from 1-arylthio and 1-arylselenoglycosides using 4-methyl(difluoroiodo)benzene. TETRAHEDRON 52(1), 149-156
    • Caddick, S., Jenkins, K. (1996). A new dynamic resolution strategy for asymmetric synthesis. TETRAHEDRON LETT 37(8), 1301-1304
    • Caddick, S., Jenkins, K. (1996). Dynamic resolutions in asymmetric synthesis. CHEM SOC REV 25(6), 447-&

    1995

    • CADDICK, S. (1995). MICROWAVE-ASSISTED ORGANIC-REACTIONS. TETRAHEDRON 51(38), 10403-10432
    • CADDICK, S., ABOUTAYAB, K., WEST, R. I. (1995). NOVEL INTRAMOLECULAR RADICAL DISPLACEMENT-REACTIONS OF 2-INDOLYL ARYL SULFIDES AND SULFOXIDES. J CHEM SOC CHEM COMM (13), 1353-1354
    • CADDICK, S., KHAN, S. (1995). PREPARATION OF THE A-RING OF NEOCARZINOSTATIN AND KEDARCIDIN CHROMOPHORES VIA A STEREOCONTROLLED BASE-MEDIATED ISOMERIZATION REACTION. J CHEM SOC CHEM COMM (19), 1971-1972
    • HOLMES, E., CADDICK, S., LINDON, J. C., WILSON, I. D., KRYVAWYCH, S., NICHOLSON, J. K. (1995). H-1 AND H-2 NMR SPECTROSCOPIC STUDIES ON THE METABOLISM AND BIOCHEMICAL EFFECTS OF 2-BROMOETHANAMINE IN THE RAT. BIOCHEM PHARMACOL 49(10), 1349-1359
    • NICHOLLS, A. W., CADDICK, S., WILSON, I. D., FARRANT, R. D., LINDON, J. C., NICHOLSON, J. K. (1995). HIGH-RESOLUTION NMR SPECTROSCOPIC STUDIES ON THE METABOLISM AND FUTILE DEACETYLATION OF 4-HYDROXYACETANILIDE (PARACETAMOL) IN THE RAT. BIOCHEM PHARMACOL 49(8), 1155-1164

    1994

    • Caddick, S., Akira, K., Farrant, J. C., Lindon, J. C., Nicholls, J. K., Nicholson, J. K. (1994). High-field deuterium nuclear magnetic resonance spectroscopic monitoring of the pharmacokinetics of selectively deuterated benzoic acid in man. Analytical Biochemistry 221(2), 297-302
    • PARSONS, P. J., CADDICK, S. (1994). A FREE-RADICAL APPROACH TO CYCLOPENTANONE AND SPIROCYCLIC SYSTEMS - DEVELOPMENT OF A 1,5-ALLYLIC ABSTRACTION-CYCLIZATION SEQUENCE. TETRAHEDRON 50(47), 13523-13532

    1993

    • CADDICK, S., ABOUTAYAB, K., WEST, R. (1993). AN INTRAMOLECULAR RADICAL CYCLIZATION APPROACH TO FUSED [1,2-A]INDOLES. SYNLETT (3), 231-232
    • CADDICK, S., KHAN, S. (1993). INTERMOLECULAR RADICAL DISPLACEMENT-REACTIONS OF HETEROAROMATIC ARYL SULFONES. TETRAHEDRON LETT 34(46), 7469-7470

    1992

    • BORTHWICK, A. D., CADDICK, S., PARSONS, P. J. (1992). APPROACHES TO BICYCLIC RING-SYSTEMS VIA 1,5 ALLYLIC ABSTRACTION CYCLIZATION. TETRAHEDRON 48(48), 10655-10666
    • CADDICK, S., JOSHI, S. (1992). A REGIOSELECTIVE SYNTHESIS OF HETEROAROMATIC STANNANES VIA RADICAL DISPLACEMENT OF HETEROAROMATIC TOSYLATES. SYNLETT (10), 805-806

    1991

    • CADDICK, S. (1991). CORRECTION. J CHEM SOC CHEM COMM (16), 1140-1140
    • CADDICK, S., MOTHERWELL, W. B., WILKINSON, J. A. (1991). A CONCISE METHOD FOR THE PREPARATION OF GLYCOSYL FLUORIDES VIA DISPLACEMENT-REACTIONS OF 1-ARYLTHIOGLYCOSIDES WITH 4-METHYL(DIFLUOROIODO)BENZENE. J CHEM SOC CHEM COMM (10), 674-675

    1990

    • BORTHWICK, A. D., CADDICK, S., PARSONS, P. J. (1990). 1,5 ALLYLIC ABSTRACTION, CYCLIZATION - A NEW ROUTE TO 5 MEMBERED CARBOCYCLES. TETRAHEDRON LETT 31(47), 6911-6914