Professor Stephen Caddick
Vice-Provost ( Enterprise)
Vernon Professor of Organic Chemistry and Chemical Biology
Prof Stephen Caddick
Research areas of interest include:
- Thiologics - www.thiologics.com
- Chemical Biology
- Organic Synthesis
- Synthetic Methodology
- Diversity Oriented Synthesis
- Protein Ligand Interactions
- Structure based design
- Medicinal chemistry
The Caddick laboratory has a wide range of research interests cutting across synthetic organic chemistry, organometallic chemistry, medicinal chemistry, chemical biology and drug discovery. We have a multi-disciplinary laboratory of around 12 researchers with skills in molecular / cell biology, bioinformatics and synthetic chemistry, with considerable industry links. Our research interests can be divided into three broad areas of activity.
1. Discovery research and innovation in organic synthesis
We are strongly committed to carrying out blue sky research in organic synthesis in which we test new concepts in organic synthesis. This is because new chemical reaction processes are vital if we are to make new molecular entities. A recent example has been our discovery that air can be used as a reagent to make carbon-carbon and carbon-nitrogen bonds. We have many areas of interest in organometallic chemistry, amino-acid chemistry, catalysis and a variety of other synthetic programmes.
2. Development of small molecule tools for applications in biology
We are committed to developing new approaches for the development of tool compounds to help understand fundamental biology and to help initiate studies in medicinal chemistry. In particular our work on sulfonates and sulfonamides has been successfully applied to a number of exciting biological targets from HIV to DDAH inhibition. We have a wide range of expert collaborators and some examples of current projects include: methylarginine processing enzymes (with Dr Leiper, MRC); nuclear transport of HIV (with Dr Fassati, UCL); β-adrenergic receptor antagonists (with Drs Baker, Vinter and Tinker, UCL); epicardial stem cell differentiation (with Prof. Riley, ICH); coagulation & respiratory disease (Prof Chambers, UCL)
3. Synthetic protein chemistry and chemical mutagenesis
Over the last few years we have become very interested in the power of organic synthesis for selective modification of proteins. In a very productive collaboration with Dr James Baker (UCL Chemistry) we have developed a number of new strategies for reversible and irreversible modification of proteins. Most recently we have applied this work to the development of a new GFP / FRET construct – which has been applied to cellular systems. Biological molecules are enormously important in the development of the next generation of diagnostics and therapeutics and our ability to carry out selective modification provides unique opportunities for applications in medicine and health.
4. ThioLogics – Delivering Homogeneous Protein Modification
Thiologics is a UCLB-owned company spun-out of the Department of Chemistry, UCL, in June 2011. The company aims to commercialise new bioconjugation technologies developed through collaboration between our group and Dr James Baker. ThioLogics is particularly focused on delivering technology that will enable the construction of homogeneous antibody drug conjugate therapeutics (ADCs) (www.thiologics.com).
Moody, P., Smith, M. E. B., Ryan, C. P., Chudasama, V., Baker, J. R., Molloy, J., Caddick, S. (2012) Bromomaleimide-linker bioconjugates are cleavable in mammalian cells. ChemBiochem. 13(10), 39-41 (doi: 10.1002/cbic.201100603)
Schumacher, F. F., Nobles, M., Ryan, C. P., Smith, M. E., Tinker, A., Caddick, S., Baker, J. R. (2011). In situ maleimide bridging of disulfides and a new approach to protein PEGylation. Bioconjug. Chem. 22(2), 132-136 (doi:10.1021/bc1004685)
Chudasama, V., Smith, M. E., Schumacher, F. F., Papaioannou, D., Waksman, G., Baker, J. R., Caddick, S. (2011). Bromopyridazinedione-mediated protein and peptide bioconjugation. Chem. Commun. 47(31), 8781-8783 (doi:10.1039/c1cc12807h)
Caddick, S., Smith, M.E.B., Baker, J. (2011) Reversible covalent linkage of functional molecules. Patent WO/2011/018611
Smith, M. E. B.,Schumacher, F. F., Ryan, C. P., Tedaldi, L. M., Papaioannou, D., Waksman, G., Caddick, S. and Baker, J., R. (2010) Protein Modification, Bioconjugation and Disulfide Bridging using Bromomaleimides, J. Am. Chem. Soc., 132(6), 1960-1965 (doi:10.1021/ja908610s)
Chudasama, V., Fitzmaurice, R. J., Caddick, S. (2010). Hydroacylation of alpha,beta-unsaturated esters via aerobic C-H activation. Nat. Chem. 2(7), 592-596 (doi:10.1038/NCHEM.685)
- 2010-to date: Vice-Provost (Enterprise)
- 2008-2010: Head of Department of Chemistry
- 2003-to date: Charles Vernon Professor of Organic Chemistry and Chemical Biology
- 2003-2003: Professor of Chemistry, University of Sussex
- 1997-2002: Senior Lecturer, University of Sussex
- 1993-1997: Lecturer, University of Sussex
- 1991-1993: Lecturer, Birkbeck College, University of London
- 1989-1991: Post Doctoral Fellowship, Imperial College, London
- 1984-1986: Senior Scientific Assistant, FBC Ltd. Chesterford Park
- 1986-1989: PhD. University of Southampton
- 1984-1986: GRSC. CCAT - Part Time
- 1981-1984: BSc. Chemistry. Paisley College
Stephen Caddick carried out his undergraduate degree at Paisley College and then part time (GRSC) whilst working for FBC Ltd /Shering at Chesterford Park Research Station. In 1986 he moved to the University of Southampton to work with P. J. Parsons for a PhD. In 1989 he gained a PhD degree and moved to Imperial College London to work with W. B. Motherwell on alkaloid and carbohydrate synthesis. In 1991 he was appointed to a lectureship at Birkbeck College. In 1993 he moved to the University of Sussex as a lecturer (1993-1997), senior lecturer (1997-2002) and professor (2003). He joined the staff at UCL as Charles Vernon Professor of Organic Chemistry and Chemical Biology in October 2003.