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Dr Stefan Howorka

Organic Chemistry and Chemical Biology

Dr Stefan Howorka
Address: Department of Chemistry, UCL
Phone No: +44 (0)20 7679 4702
Fax No: +44 (0)20 7679 7463
Extension: 24702
Email: s.howorka@ucl.ac.uk
Photo of Stefan Howorka

Research areas of interest include:

  • Protein biochemistry and protein engineering
  • Bioconjugate chemistry
  • Single-molecule detection
  • Nanobiotechnology
  • Surface chemistry 

Summary


Stefan Howorka Research Image

The Howorka group is developing chemical tools and approaches to facilitate single-molecule research. Proteins are engineered to create functional biomaterials and patterned structures useful in analytical chemistry and biophysics. In addition, surfaces of solid substrates are modified and applied for the ultrasensitive detection of DNA. 

Research Profile

Selected Publications

  1. Kinns,H., Badelt-Lichtblau,H., Egelseer,E.M., Sleytr,U.B., Howorka,S. (2010). Identifying Assembly-Inhibiting and Assembly-Tolerant Sites in the SbsB S-Layer Protein from Geobacillus stearothermophilus. J. Mol. Biol. 395, 742-753
  2. Borsenberger,V., Mitchell,N., Howorka,S. (2009). Chemically Labeled Nucleotides and Oligonucleotides Encode DNA for Sensing with Nanopores. J. Am. Chem. Soc. 131(22), 7530-7531
  3. Howorka,S., Ziwy,S. (2009). Nanopore Analytics: Sensing of Single Molecules. Chemical Society Reviews 38(8), 2360-2384.
  4. Mitchell,N., Schlapak,R., Kastner,M., Armitage,D., Chrzanowski,W., Riener,J., Hinterdorfer,P., Ebner,A., Howorka,S. (2009). A DNA nanostructure for the functional assembly of chemical groups with tunable stoichiometry and defined nanoscale geometry.Angew. Chem Int. Ed. 48(3), 525-527.
  5. Schlapak,R., Armitage,D., Saucedo-Zeni,N., Chrzanowski,W., Hohage,M., Caruana,D., Howorka,S. (2009). Selective protein and DNA adsorption on PLL-PEG films modulated by ionic strength. Soft Matter 5(3), 613-621

All Publications

  • 2009/10 to date: Assoc. Prof. / Reader in Chemical Biology, Department of Chemistry, University College London
  • 2005 to 2009: Assist. Prof. / Lecturer in Chemical Biology, Department of Chemistry, University College London
  • 2001 - 2004: Group Leader, Biotech incubator Upper Austrian Research GmbH, Linz, Austria
  • 1999 - 2001: Postdoctoral Fellow, Texas A&M University System Health Science Center, Prof. Bayley
  • 1995 – 1999: PhD, University of Vienna, Austria / Research stay at The Texas A&M University System Health Science Center
  • 1988 – 1995: Diploma Study of Biochemistry (MSc), University of Vienna, Austria