Dr Jon Wilden
Organic Chemistry and Chemical Biology
Dr Jon Wilden
Address: Department of Chemistry, UCL
Phone No: +44 (0)20 7679 3395
Research areas of interest include:
- Transition-metal free organic synthesis
- Electron transfer reactions
- Radical reactions
- Organic reaction mechanisms
- Biologically active molecules and peptidomimetics
Our research is directed towards the synthesis of small molecule entities with biological activity. In particular we are interested in the preparation of peptidomimetics containing unnatural peptide bonds such as sulfonamides since this group has recently been shown to be a transition state mimetic of peptide hydrolysis and potent irreversible inhibitors of cysteine proteases. The course of this research has led us to a number of other areas including total synthesis of natural products and novel synthetic methodology.
- Trichlorophenol (TCP) sulfonate esters: A selective alternative to pentafluorophenol (PFP) esters and sulfonyl chlorides for the preparation of sulfonamides. Wilden, J. D.; Geldeard, L.; Lee, C, C.; Judd, D. B.; Caddick, S. Chem. Commun. 2007 , 1074-1076.
- A New synthesis of β-Sultams from Pentafluorophenyl Sulfonates. Lewis, A. K. De K.; Mok, B. J.; Tocher, D. A.; Wilden, J. D.; Caddick, S. Org. Lett. 2006 , 8, 5513-5515.
- Inhibition of Dimethylarginine Dimethylaminohydrolase (DDAH) and Arginine Deiminase (ADI) by Pentafluorophenyl (PFP) Sulfonates. Vallance, P.; Bush, H. D.; Mok, B. J.; Hurtado-Guerrero, R.; Gill, H.; Rossiter, S.; Wilden, J. D.; Caddick, S. Chem. Commun. 2005 , 5563-5565.
- Rate Enhancement of PFP Sulfonate Ester Aminolysis by Chloride Salts in Organic and Aqueous Media . Wilden, J. D.; Caddick, S.; Judd, D. B. Tetrahedron Lett. 2005 , 46, 7637-7340.*
- Observations on the Reactivity of Pentafluorophenylsulfonate Esters. Caddick, S.; Wilden, J. D.; Judd, D. B.Chem. Commun. 2005 , 2727-2728.