Dr James Baker - Publications


    • Marculescu, C., Kossen, H., Morgan, R. E., Mayer, P., Fletcher, S. A., Tolner, B., Chester, K. A., Jones, L. H., Baker, J. R. (2014). Aryloxymaleimides for cysteine modification, disulfide bridging and the dual functionalization of disulfide bonds. Chem Commun (Camb) doi:10.1039/c4cc02107j. Author URL


    • Baker, J. R., Schumacher, F. F., Caddick, S., Smith, M. E. B., Chudasama, V., Maruani, A. (2013). Chemical modification of antibodies. Patent WO/2013/132268
    • Castañeda, L., Maruani, A., Schumacher, F. F., Miranda, E., Chudasama, V., Chester, K. A., Baker, J. R., Smith, M. E., Caddick, S. (2013). Acid-cleavable thiomaleamic acid linker for homogeneous antibody-drug conjugation. Chem Commun (Camb) doi:10.1039/c3cc45220d. Author URL
    • Castañeda, L., Wright, Z. V. F., Marculescu, C., Tran, T. M., Chudasama, V., Maruani, A., Hull, E. A., Nunes, J. P. M., Fitzmaurice, R. J., Smith, M. E. B., Jones, L. H., Caddick, S., Baker, J. R. (2013). A mild synthesis of N-functionalised bromomaleimides, thiomaleimides and bromopyridazinediones. Tetrahedron Letters
    • Nathani, R. I., Chudasama, V., Ryan, C. P., Moody, P. R., Morgan, R. E., Fitzmaurice, R. J., Smith, M. E., Baker, J. R., Caddick, S. (2013). Reversible protein affinity-labelling using bromomaleimide-based reagents. Org Biomol Chem 11(15), 2408-2411 doi:10.1039/c3ob40239h. Author URL
    • Roupany, A. J. A., Baker, J. R. (2013). Diverse products accessible via [2+2] photocycloadditions of 3-aminocyclopentenones. RSC ADVANCES 3(27), 10650-10653 doi:10.1039/c3ra42106f. Author URL
    • Schumacher, F. F., Sanchania, V. A., Tolner, B., Wright, Z. V., Ryan, C. P., Smith, M. E., Ward, J. M., Caddick, S., Kay, C. W., Aeppli, G., Chester, K. A., Baker, J. R. (2013). Homogeneous antibody fragment conjugation by disulfide bridging introduces 'spinostics'. Sci Rep 3, 1525- doi:10.1038/srep01525. Author URL
    • Youziel, J., Akhbar, A. R., Aziz, Q., Smith, M. E., Caddick, S., Tinker, A., Baker, J. R. (2013). Bromo- and thiomaleimides as a new class of thiol-mediated fluorescence 'turn-on' reagents. Org Biomol Chem doi:10.1039/c3ob42141d. Author URL


    • Jones, M. W., Strickland, R. A., Gibson, M. I., Haddleton, D. M., Schumacher, F. F., Caddick, S., Baker, J. R. (2012). Highly efficient disulfide bridging polymers for bioconjugates from radical-compatible dithiophenol maleimides. Chemical Communications 48(34), 4064-4066 doi:10.1039/c2cc30259d.
    • Jones, M. W., Strickland, R. A., Gibson, M. I., Haddleton, D. M., Schumacher, F. F., Caddick, S., Baker, J. R. (2012). Polymeric dibromomaleimides as extremely efficient disulfide bridging bioconjugation and pegylation agents. Journal of the American Chemical Society 134(3), 1847-1852 doi:10.1021/ja210335f.
    • Moody, P., Smith, M. E., Ryan, C. P., Chudasama, V., Baker, J. R., Molloy, J., Caddick, S. (2012). Bromomaleimide-Linked Bioconjugates Are Cleavable in Mammalian Cells. Chembiochem 13(1), 39-41 doi:10.1002/cbic.201100603. Author URL
    • Tedaldi, L. M., Aliev, A. E., Baker, J. R. (2012). [2+2] Photocycloadditions of thiomaleimides. Chem Commun (Camb) 48(39), 4725-4727 doi:10.1039/c2cc31673k. Author URL


    • Baker, J. R., Caddick, S., Smith, M. E. B. (2011). Functionalisation of solid substrates. Patent
    • Baker, J. R., Caddick, S., Smith, M. E. B. (2011). Reversible covalent linkage of functional moieties. Patent
    • Baker, J. R., Caddick, S., Smith, M. E. B. (2011). Thiol protecting group. Patent
    • Chudasama, V., Smith, M. E., Schumacher, F. F., Papaioannou, D., Waksman, G., Baker, J. R., Caddick, S. (2011). Bromopyridazinedione-mediated protein and peptide bioconjugation. Chem Commun (Camb) 47(31), 8781-8783 doi:10.1039/c1cc12807h. Author URL
    • Hothersall, J. D., Black, J., Caddick, S., Vinter, J. G., Tinker, A., Baker, J. R. (2011). The design, synthesis and pharmacological characterization of novel beta(2)-adrenoceptor antagonists. Br J Pharmacol 164(2), 317-331 doi:10.1111/j.1476-5381.2011.01269.x. Author URL
    • Iqbal, F., Ellwood, R., Mortensen, M., Smart, T. G., Baker, J. R. (2011). Synthesis and evaluation of highly potent GABA(A) receptor antagonists based on gabazine (SR-95531). Bioorg Med Chem Lett 21(14), 4252-4254 doi:10.1016/j.bmcl.2011.05.067. Author URL
    • RYAN, C., SMITH, M., SCHUMACHER, F., GROHMANN, D., PAPAIOANNOU, D., WAKSMAN, G., WERNER, F., BAKER, J., CADDICK, S. (2011). Tunable reagents for multi-functional bioconjugation: reversible or permanent chemical modification of proteins and peptides by control of maleimide hydrolysis. Chemical Communications 21(47) [Submitted]
    • Schumacher, F. F., Nobles, M., Ryan, C. P., Smith, M. E., Tinker, A., Caddick, S., Baker, J. R. (2011). In Situ Maleimide Bridging of Disulfides and a New Approach to Protein PEGylation. Bioconjug Chem 22(2), 132-136 doi:10.1021/bc1004685. Author URL


    • Baker, J. R., Hothersall, J. D., Fitzmaurice, R. J., Tucknott, M., Vinter, A., Tinker, A., Caddick, S. (2010). An efficient asymmetric synthesis of the potent beta-blocker ICI-118,551 allows the determination of enantiomer dependency on biological activity. Chem Commun (Camb) 46(22), 3953-3954 doi:10.1039/c0cc00142b. Author URL
    • Smith, M., Caddick, S., Baker, J. R., Waksman, G., Schumacher, F., Papaiannou, D., Tedaldi, L., Ryan, C. (2010). Protein Modification, Bioconjugation, and Disulfide Bridging Using Bromomaleimides. Journal of the American Chemical Society (132), 1960-1965 doi:10.1021/ja908610s.


    • Baker, J. R., Woolfson, D. N., Muskett, F. W.,, Stoneman, M. D., Urbaniak, M. D., Caddick, S. (2009). Wiley encyclopedia of chemical biology (Protein-Small Molecule Interactions in Neocarzinostatin). In Begley, T. P., Sons, J. W. (Eds.). Wiley encyclopedia of chemical biology ( ).
    • Tedaldi, L. M., Baker, J. R. (2009). In situ Reduction in Photocycloadditions: A Method to Prevent Secondary Photoreactions. ORG LETT 11(4), 811-814 doi:10.1021/ol8026494.
    • Tedaldi, L. M., Smith, M. E. B., Nathani, R. I., Baker, J. R. (2009). Bromomaleimides: new reagents for the selective and reversible modification of cysteine. CHEM COMMUN (43), 6583-6585 doi:10.1039/b915136b.


    • Baker, J. R., Thominet, O., Britton, H., Caddick, S. (2007). An efficient synthesis of epoxydiynes and a key fragment of neocarzinostatin chromophore. Organic Letters 9(1), 45-48 doi:10.1021/ol062461g.
    • Baker, J. R., Woolfson, D. N., Muskett, F. W., Stoneman, R. G., Urbaniak, M. D., Caddick, S. (2007). Protein-small molecule interactions in neocarzinostatin, the prototypical enediyne chromoprotein antibiotic. ChemBioChem 8, 704-717 doi:10.1002/cbic.200600534. Author URL
    • Gulten, S., Sharpe, A., Baker, J. R., Booker-Milburn, K. I. (2007). Use of temporary tethers in the intramolecular [2+2] photocycloaddition reactions of tetrahydrophthalimide derivatives: a new approach to complex tricyclic lactones. TETRAHEDRON LETTERS 63, 3659-3671 doi:10.1016/j.tet.2007.02.064.
    • Hickford, P. J., Baker, J. R., Bruce, I., Booker-Milburn, K. I. (2007). Acid-catalyzed rearrangement of fused alkylideneoxetanols. Organic Letters 9(23), 4681-4684 doi:10.1021/ol701625q.
    • Thominet, O., Baker, J. R., Britton, H., Etheridge, Z. C., Soscia, M. G., Caddick, S. (2007). Synthetic strategies to epoxydiynes and a key synthon of the neocarzinostatin chromophore. Organic and Biomolecular Chemistry 5(22), 3703-3712 doi:10.1039/b711196g. Author URL


    • Booker-Milburn, K. I., Baker, J. R., Bruce, I. (2004). Rapid access to azepine-fused oxetanols from alkoxy-substituted maleimides. Organic Letters 6, 1481-1484 doi:10.1021/ol049645k.


    • Clarke, P. A., Kayaleh, N. E., Smith, M. A., Baker, J. R., Bird, S. J., Chan, C. (2002). A one-step procedure for the monoacylation of symmetrical 1,2-diols. J Org Chem 67(15), 5226-5231 Author URL