Dr James Baker

Organic Chemistry and Chemical Biology

Dr James Baker

Address: Room 2.25, KLB, UCL
Phone No: +44 (0)20 7679 2653
Fax No: +44 (0)20 7679 7463
Extension: 32653
Photo of James Baker

Research areas of interest include:

  • Organic Synthesis and Chemical Biology
  • Protein Modification, Bioconjugation
  • Antibody conjugates as Therapeutics and Diagnostics
  • Organic Photochemistry


James Baker Research Image

Our research group is focused on developing new methods in organic synthesis and chemical biology, and harnessing them in the design of therapeutics, clinical tools and probes of biological systems. We are particularly interested in investigating new approaches to the chemical modification of proteins, the construction and application of homogeneous antibody conjugates, and the photochemical control of biomolecules.

Research Profile

Selected Publications

  1. Functional native disulfide bridging enables delivery of a potent, stable and targeted antibody-drug conjugate (ADC), J. P. Nunes, M. Morais, V. Vassileva, E. Robinson, V. S. Rajkumar, M. E. Smith, R. B. Pedley, S. Caddick, J. R. Baker, V. Chudasama, Chem. Commun., 2015, 51, 10624-10627. http://dx.doi.org/10.1039/C5CC03557K
  2. Homogeneous Bispecifics by Disulfide Bridging, E. A. Hull, M. Livanos, E. Miranda, M. E. B. Smith, K. A. Chester, J. R. Baker, Bioconjugate Chem., 2014, 25, 1395-1401.http://dx.doi.org/10.1021/bc5002467
  3. Next generation maleimides enable the controlled assembly of antibody-drug conjugates via native disulfide bond bridging, F. F. Schumacher, J. P. M. Nunes, A. Maruani, V. Chudasama, M. E. B. Smith, K. A. Chester, J. R. Baker, S. Caddick, Org. Biomol. Chem., 2014, 12, 7261-7269. doi:10.1039/c4ob01550a
  4. Photo-antagonism of the GABA(A) receptor, M. Mortensen, F. Iqbal, A. P. Pandurangan, S. Hannan, R. Huckvale, M. Topf, J. R. Baker, T. G. Smart, Nature Communications, 2014, 5. doi:10.1038/ncomms5454
  5. Aryloxymaleimides for cysteine modification, disulfide bridging and the dual functionalization of disulfide bonds, C. Marculescu, H. Kossen, R. E. Morgan, P. Mayer, S. A. Fletcher, B. Tolner, K. A. Chester, L. H. Jones, J. R. Baker, Chem. Commun., 2014, 50, 7139-7142.http://dx.doi.org/10.1039/c4cc02107j
  6. Homogeneous antibody fragment conjugation by disulfide bridging introduces 'spinostics', F. F. Schumacher, V. A. Sanchania, B. Tolner, Z. V. F. Wright, C. P. Ryan, M. E. B. Smith, J. M. Ward, S. Caddick, C. W. M. Kay, G. Aeppli, K. A. Chester, J. R. Baker, Sci. Rep., 2013, 3, 1525. doi:10.1038/srep01525
  7. In Situ Maleimide Bridging of Disulfides and a New Approach to Protein PEGylation, F. F. Schumacher, M. Nobles, C. P. Ryan, M. E. B. Smith, A. Tinker, S. Caddick, J. R. Baker, Bioconjugate Chem., 2011, 22, 132-136. doi:10.1021/bc1004685
  8. Protein modification, bioconjugation, and disulfide bridging using bromomaleimides, M. E. B. Smith, F. F. Schumacher, C. P. Ryan, L. M. Tedaldi, D. Papaioannou, G. Waksman, S. Caddick, J. R. Baker, J. Am. Chem. Soc., 2010, 132, 1960-1965. doi:10.1021/ja908610s

All Publications