Dr James Baker

Organic Chemistry and Chemical Biology

Dr James Baker

Address: Room 2.25, KLB, UCL
Phone No: +44 (0)20 7679 2653
Fax No: +44 (0)20 7679 7463
Extension: 32653
Photo of James Baker

Research areas of interest include:

  • Organic Synthesis
  • Chemical Biology
  • Organic Photochemistry
  • Protein Modification

Summary

James Baker Research Image

Our research interests centre around the areas of organic synthesis and chemical biology. Ongoing projects include; 1) The development of new reagents for the selective and reversible modification of proteins and peptides; 2) Harnessing the power of photochemistry for application to organic synthesis; 3) The design and synthesis of photoaffinity labelled antagonists of the GABAA ion channel. 

Research Profile

Selected Publications

  1. In Situ Maleimide Bridging of Disulfides and a New Approach to Protein PEGylation, F. F. Schumacher, M. Nobles, C. P. Ryan, M. E. B. Smith, A. Tinker, S. Caddick, J. R. Baker, Bioconjug. Chem. 2011, 22, 132-136.
  2. Tunable reagents for multi-functional bioconjugation: reversible or permanent chemical modification of proteins and peptides by control of maleimide hydrolysis, C. P. Ryan, M. E. B. Smith, F. F. Schumacher, D. Grohmann, D. Papaioannou, G. Waksman, F. Werner, J. R. Baker, S. Caddick, Chem. Comm. 2011, 47, 5452-5454
  3. Protein modification, bioconjugation, and disulfide bridging using bromomaleimides, M. E. B. Smith, F. F. Schumacher, C. P. Ryan, L. M. Tedaldi, D.  Papaioannou, G. Waksman, S. Caddick, J. R. Baker, J. Am. Chem. Soc.2010,132, 1960-1965.
  4. Bromomaleimides; new reagents for the selective and reversible modification of cysteine, DOI: 10.1039/b915136b, J. R. Baker, L. M. Tedaldi, M. E. B. Smith, R. Nathani, Chem. Comm. 2009DOI: 10.1039/b915136b.
  5. In Situ Reduction in Photocycloadditions: A Method to Prevent Secondary Photoreactions. Baker J.; Tedaldi, L. Org. Lett.2009, 11, 811-814.

All Publications