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Professor Helen Hailes - Publications

    2014

    • Richter, N., Simon, R. C., Kroutil, W., Ward, J. M., Hailes, H. C. (2014). Synthesis of pharmaceutically relevant 17-α-amino steroids using an ω-transaminase. Chem Commun (Camb) doi:10.1039/c3cc49080g. Author URL

    2013

    • Foster, R. W., Hailes, H. C., Sheppard, T. D., Tame, C. J. (2013). Highly regioselective synthesis of substituted isoindolinones via ruthenium-catalyzed alkyne cyclotrimerizations. Advanced Synthesis and Catalysis 342(8) doi:10.1002/adsc.201300055.
    • Hailes, H. C., Rother, D., Müller, M., Westphal, R., Ward, J. M., Pleiss, J., Vogel, C., Pohl, M. (2013). Engineering stereoselectivity of ThDP-dependent enzymes. FEBS J doi:10.1111/febs.12496. Author URL
    • Kenny, G. D., Tagalakis, A. D., Hart, S. L., Lythgoe, M. F., Bienemann, A. S., Gill, S. S., White, E. A., Pugh, J. A., McLeod, C. W., Welser, K., Campbell, F., Tabor, A. B., Hailes, H. C. (2013). Multifunctional receptor-targeted nanocomplexes for the delivery of therapeutic nucleic acids to the Brain. Biomaterials 34(36), 9190-9200 doi:10.1016/j.biomaterials.2013.07.081.
    • Mitchell, N., Kalber, T. L., Cooper, M. S., Sunassee, K., Chalker, S. L., Shaw, K. P., Ordidge, K. L., Badar, A., Janes, S. M., Blower, P. J., Lythgoe, M. F., Hailes, H. C., Tabor, A. B. (2013). Incorporation of paramagnetic, fluorescent and PET/SPECT contrast agents into liposomes for multimodal imaging. Biomaterials 34(4), 1179-1192 doi:10.1016/j.biomaterials.2012.09.070. Author URL
    • Pennell, M. N., Foster, R. W., Turner, P. G., Hailes, H. C., Tame, C. J., Sheppard, T. D. (2013). Gold catalysed synthesis of 3-alkoxyfurans at room temperature. Chem Commun (Camb) doi:10.1039/c3cc48290a. Author URL
    • Sanchez-Vazquez, S. A., Hailes, H. C., Evans, J. R. G. (2013). Hydrophobic Polymers from Food Waste: Resources and Synthesis. POLYMER REVIEWS 53(4), 627-694 doi:10.1080/15583724.2013.834933. Author URL
    • Sehl, T., Hailes, H. C., Ward, J. M., Wardenga, R., von Lieres, E., Offermann, H., Westphal, R., Pohl, M., Rother, D. (2013). Two Steps in One Pot: Enzyme Cascade for the Synthesis of Nor(pseudo)ephedrine from Inexpensive Starting Materials. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 52(26), 6772-6775 doi:10.1002/anie.201300718. Author URL
    • Welser, K., Campbell, F., Kudsiova, L., Mohammadi, A., Dawson, N., Hart, S. L., Barlow, D. J., Hailes, H. C., Lawrence, M. J., Tabor, A. B. (2013). Gene delivery using ternary lipopolyplexes incorporating branched cationic peptides: The role of peptide sequence and branching. Mol Pharm 10(1), 127-141 doi:10.1021/mp300187t. Author URL

    2012

    • Baboo, J. Z., Galman, J. L., Lye, G. J., Ward, J. M., Hailes, H. C., Micheletti, M. (2012). An automated microscale platform for evaluation and optimization of oxidative bioconversion processes. Biotechnol Prog 28(2), 392-405 doi:10.1002/btpr.1500. Author URL
    • Baboo, J. Z., Lye, G. J., Micheletti, M., Galman, J. L., Hailes, H. C., Ward, J. M. (2012). An automated microscale platform for evaluation and optimization of oxidative bioconversion processes. Biotechnology Progress 28(2), 392-405 doi:10.1002/btpr.1500.
    • Barua, N. U., Miners, J. S., Bienemann, A. S., Wyatt, M. J., Welser, K., Tabor, A. B., Hailes, H. C., Love, S., Gill, S. S. (2012). Convection-Enhanced Delivery of Neprilysin: A Novel Amyloid-beta-Degrading Therapeutic Strategy. J Alzheimers Dis 32(1), 43-56 doi:10.3233/JAD-2012-120658. Author URL
    • Galman, J. L., Steadman, D., Haigh, L. D., Hailes, H. C. (2012). Investigating the reaction mechanism and organocatalytic synthesis of α,α′-dihydroxy ketones. Org Biomol Chem 10(13), 2621-2628 doi:10.1039/c2ob06939c. Author URL
    • Kenny, G. D., Villegas-Llerena, C., Tagalakis, A. D., Campbell, F., Welser, K., Botta, M., Tabor, A. B., Hailes, H. C., Lythgoe, M. F., Hart, S. L. (2012). Multifunctional receptor-targeted nanocomplexes for magnetic resonance imaging and transfection of tumours. Biomaterials 33(29), 7241-7250 doi:10.1016/j.biomaterials.2012.06.042. Author URL
    • O'Sullivan, B., Al-Bahrani, H., Lawrence, J., Campos, M., Baganz, F., Szita, N., Cázares, A., Hailes, H. C., Wohlgemuth, R. (2012). Modular microfluidic reactor and inline filtration system for the biocatalytic synthesis of chiral metabolites. Journal of Molecular Catalysis B: Enzymatic 77, 1-8 doi:10.1016/j.molcatb.2011.12.010.
    • Payongsri, P., Steadman, D., Strafford, J., MacMurray, A., Hailes, H. C., Dalby, P. A. (2012). Rational substrate and enzyme engineering of transketolase for aromatics. Org Biomol Chem 10(45), 9021-9029 doi:10.1039/c2ob25751c. Author URL
    • Pesnot, T., Gershater, M. C., Ward, J. M., Hailes, H. C. (2012). The Catalytic Potential of Coptis japonica NCS2 Revealed - Development and Utilisation of a Fluorescamine-Based Assay. ADVANCED SYNTHESIS & CATALYSIS 354(16), 2997-3008 doi:10.1002/adsc.201200641. Author URL
    • Sehl, T., Simon, R. C., Hailes, H. C., Ward, J. M., Schell, U., Pohl, M., Rother, D. (2012). TTC-based screening assay for ω-transaminases: A rapid method to detect reduction of 2-hydroxy ketones. J Biotechnol 159(3), 188-194 doi:10.1016/j.jbiotec.2011.12.023. Author URL
    • Strafford, J., Payongsri, P., Hibbert, E. G., Morris, P., Batth, S. S., Steadman, D., Smith, M. E., Ward, J. M., Hailes, H. C., Dalby, P. A. (2012). Directed evolution to re-adapt a co-evolved network within an enzyme. J Biotechnol 157(1), 237-245 doi:10.1016/j.jbiotec.2011.11.017. Author URL

    2011

    • Campbell, F., Welser, K., Mohammadi, A., Kudsiova, L., Lawrence, M. J., Tabor, A. B., Hailes, H. C. (2011). Non-viral, coated nanoparticles as vectors for gene therapy. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY. ( Vol. 242 ). Author URL
    • Goodworth, K. J., Hervé, A. -. C., Hervé, G., Casades, I., Hailes, H. C., Stavropoulos, E., Tascon, R. E., Colston, M. J., Hill, A. M., Weingarten, G. G. (2011). Synthesis and in vivo biological activity of large-ringed calixarenes against Mycobacterium tuberculosis. Tetrahedron 67(2), 373-382 doi:10.1016/j.tet.2010.11.034.
    • Kudsiova, L., Fridrich, B., Ho, J., Mustapa, M. F., Campbell, F., Welser, K., Keppler, M., Ng, T., Barlow, D. J., Tabor, A. B., Hailes, H. C., Lawrence, M. J. (2011). Lipopolyplex Ternary Delivery Systems Incorporating C14 Glycerol-Based Lipids. Mol Pharm 8(5), 1831-1847 doi:10.1021/mp2001796. Author URL
    • Kudsiova, L., Ho, J., Fridrich, B., Harvey, R., Keppler, M., Ng, T., Hart, S. L., Tabor, A. B., Hailes, H. C., Lawrence, M. J. (2011). Lipid chain geometry of C14 glycerol-based lipids: effect on lipoplex structure and transfection. Mol Biosyst 7(2), 422-436 doi:10.1039/c0mb00149j. Author URL
    • Lafitte, V. G. H., Aliev, A. E., Greco, E., Bala, K., Golding, P., Hailes, H. C. (2011). Quadruple hydrogen bonded cytosine modules: N-1 functionalised arrays. NEW J CHEM 35(7), 1522-1527 doi:10.1039/c1nj20162j.
    • Lye, G., Paul, D., Frank, B., John, W., Helen, H. (2011). Biocatalysis is the future... The future is now! Chemical Engineer (839), 36-38
    • Manunta, M. D., McAnulty, R. J., Tagalakis, A. D., Bottoms, S. E., Campbell, F., Hailes, H. C., Tabor, A. B., Laurent, G. J., O'Callaghan, C., Hart, S. L. (2011). Nebulisation of Receptor-Targeted Nanocomplexes for Gene Delivery to the Airway Epithelium. PLoS One 6(10), e26768- doi:10.1371/journal.pone.0026768. Author URL
    • Mitchell, N., Kalber, T., Cooper, M., Cheung, A., Fruhwirth, G., Blower, P., Ng, T., Lythgoe, M., Hailes, H. C., Tabor, A. B. (2011). Multimodal imaging of drug delivery using liposomes functionalised with MRI, PET and SPECT contrast agents to target sites of pathological interest. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY. ( Vol. 242 ). Author URL
    • Mohammadi, A., Welser, K., Kudsiova, L., Campbell, F., Dawson, N. L., Lawrence, J., Tabor, A., Hailes, H. C. (2011). Novel cationic lipopolyplexes as gene therapy vectors. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY. ( Vol. 242 ). Author URL
    • Pesnot, T., Gershater, M. C., Ward, J. M., Hailes, H. C. (2011). Phosphate mediated biomimetic synthesis of tetrahydroisoquinoline alkaloids. Chem Commun (Camb) 47(11), 3242-3244 doi:10.1039/c0cc05282e. Author URL
    • Rios-Solis, L., Halim, M., Cazares, A., Morris, P., Ward, J. M., Hailes, H. C., Dalby, P. A., Baganz, F., Lye, G. J. (2011). A toolbox approach for the rapid evaluation of multi-step enzymatic syntheses comprising a 'mix and match' E. coli expression system with microscale experimentation. BIOCATAL BIOTRANSFOR 29(5), 192-203 doi:10.3109/10242422.2011.609589.
    • Tagalakis, A. D., Grosse, S. M., Meng, Q. H., Mustapa, M. F., Kwok, A., Salehi, S. E., Tabor, A. B., Hailes, H. C., Hart, S. L. (2011). Integrin-targeted nanocomplexes for tumour specific delivery and therapy by systemic administration. Biomaterials 32(5), 1370-1376 doi:10.1016/j.biomaterials.2010.10.037. Author URL
    • Welser, K., Campbell, F., Mohammadi, A., Kudsiova, L., Dawson, N. L., Lawrence, M. J., Hailes, H. C., Tabor, A. B. (2011). Tuning a gene delivery vector: the role of peptide sequence and peptide branching in delivering of DNA and siRNA to the cytoplasm. BIOPOLYMERS. ( Vol. 96 pp.516-516). WILEY-BLACKWELL.

    2010

    • Cázares, A., Galman, J. L., Crago, L. G., Smith, M. E., Strafford, J., Ríos-Solís, L., Lye, G. J., Dalby, P. A., Hailes, H. C. (2010). Non-alpha-hydroxylated aldehydes with evolved transketolase enzymes. Org Biomol Chem 8(6), 1301-1309 doi:10.1039/b924144b. Author URL
    • Chiva, A., Williams, D. E., Tabor, A. B., Hailes, H. C. (2010). Screening of polymeric supports and enzymes for the development of an endo enzyme cleavable linker. TETRAHEDRON LETT 51(20), 2720-2723 doi:10.1016/j.tetlet.2010.03.040.
    • Galman, J. L., Steadman, D., Bacon, S., Morris, P., Smith, M. E., Ward, J. M., Dalby, P. A., Hailes, H. C. (2010). alpha,alpha '-Dihydroxyketone formation using aromatic and heteroaromatic aldehydes with evolved transketolase enzymes. Chem Commun (Camb) 46(40), 7608-7610 doi:10.1039/c0cc02911d. Author URL
    • Greco, E., Aliev, A. E., Lafitte, V. G. H., Bala, K., Duncan, D., Pilon, L., Golding, P., Hailes, H. C. (2010). Cytosine modules in quadruple hydrogen bonded arrays. NEW J CHEM 34(11), 2634-2642 doi:10.1039/c0nj00197j.
    • Grosse, S. M., Tagalakis, A. D., Mustapa, M. F., Elbs, M., Meng, Q. H., Mohammadi, A., Tabor, A. B., Hailes, H. C., Hart, S. L. (2010). Tumor-specific gene transfer with receptor-mediated nanocomplexes modified by polyethylene glycol shielding and endosomally cleavable lipid and peptide linkers. FASEB J 24(7), 2301-2313 doi:10.1096/fj.09-144220. Author URL
    • Hailes, H. C., Dalby, P. A., Lye, G. J., Baganz, F., Micheletti, M., Szita, N., Ward, J. M. (2010). alpha,alpha '-Dihydroxy Ketones and 2-Amino-1,3-diols: Synthetic and Process Strategies Using Biocatalysts. Current Organic Chemistry , 1883-1893 [Submitted]
    • SMITH, M. E. B., CHEN, B. H., HIBBERT, E. G., KAULMANN, U., SMITHIES, K., GALMAN, J. L., BAGANZ, F., DALBY, P. A., HAILES, H. C., LYE, G. J., WARD, J. M., WOODLEY, J. M., MICHELETTI, M. (2010). A multi-disciplinary approach toward the rapid and preparative scale biocatalytic synthesis of chiral amino alcohols: a concise transketolase/ω-transaminase-mediated synthesis of (2S,3S)-2-aminopentane-1,3-diol. ORGANIC PROCESS RESEARCH AND DEVELOPMENT 14, 99-107 doi:10.1021/op900190y.
    • Smith, M. E. B., Chen, B. H., Hibbert, E. G., Kaulmann, U., Smithies, K., Galman, J. L., Baganz, F., Dalby, P. A., Hailes, H. C., Lye, G. J., Ward, J. M., Woodley, J. M., Micheletti, M. (2010). A Multidisciplinary Approach Toward the Rapid and Preparative-Scale Biocatalytic Synthesis of Chiral Amino Alcohols: A Concise Transketolase-/omega-Transaminase-Mediated Synthesis of (2S,3S)-2-Aminopentane-1,3-diol. Organic Process Research & Development 14, 99-107 [Submitted]
    • Smith, M. E. B., Gunn, R. M., Rosivatz, E., Mak, L. H., Woscholski, R., Hailes, H. C. (2010). Development of chemical probes: Toward the mode of action of a methylene-linked di(aryl acetate) E1. BIOORGAN MED CHEM 18(14), 4917-4927 doi:10.1016/j.bmc.2010.06.017.

    2009

    • Galman, J. L., Hailes, H. C. (2009). Application of a modified Mosher's method for the determination of enantiomeric ratio and absolute configuration at C-3 of chiral 1,3-dihydroxy ketones. Tetrahedron: Asymmetry 20(15), 1828-1831 doi:10.1016/j.tetasy.2009.07.023.
    • Hailes, H. C., Dalby P A, L., G J, W., J, M. (2009). Biocatalytic approaches to ketodiols and aminodiols. Chemistry Today 27(4), 28-31
    • Ho, K. K., Rosivatz, E., Gunn, R. M., Smith, M. E. B., Stavropoulou, A. V., Rosivatz, E., Numbere, M. G., Wong, J. B., Lafitte, V. G. H., Behrendt, J. M., Myatt, S. S., Hailes, H. C., Woscholski, R., Lam, E. W. F. (2009). The novel molecule 2-(5-(2-chloroethyl)-2-acetoxy-benzyl)-4-(2-chloroethyl)-phenyl acetate inhibits Akt signalling through JNK activation in cancer cells. The FEBS Journal 276(15), 4037-4050 doi:10.1111/j.1742-4658.2009.07112.
    • Ho, K. K., Rosivatz, E., Gunn, R. M., Smith, M. E. B., Stavropoulou, A. V., Rosivatz, E., Numbere, M. G., Wong, J. B., Lafitte, V. G. H., Behrendt, J. M., Myatt, S. S., Hailes, H. C., Woscholski, R., Lam, E. W. F. (2009). The novel molecule 2-[5-(2-chloroethyl)-2-acetoxy-benzyl]-4-(2-chloroethyl)-phenyl acetate inhibits phosphoinositide 3-kinase/Akt/mammalian target of rapamycin signalling through JNK activation in cancer cells. FEBS J 276(15), 4037-4050 doi:10.1111/j.1742-4658.2009.07112.x.
    • Mustapa, M. F., Grosse, S. M., Kudsiova, L., Elbs, M., Raiber, E. A., Wong, J. B., Brain, A. P., Armer, H. E., Warley, A., Keppler, M., Ng, T., Lawrence, M. J., Hart, S. L., Hailes, H. C., Tabor, A. B. (2009). Stabilized Integrin-Targeting Ternary LPD (Lipopolyplex) Vectors for Gene Delivery Designed To Disassemble Within the Target Cell. Bioconjug.Chem. 20(3), 518-532 doi:10.1021/bc800450r. Author URL
    • Smithies, K., Smith, M. E. B., Kaulmann, U., Galman, J. L., Ward, J. M., Hailes, H. C. (2009). Stereoselectivity of an omega-transaminase-mediated amination of 1,3-dihydroxy-1-phenylpropane-2-one. Tetrahedron: Asymmetry 20, 570-574 doi:10.1016/j.tetasy.2009.03.012.

    2008

    • Gunn, R. M., Hailes, H. C. (2008). Insights into the PI3-K-PKB-mTOR signalling pathway from small molecules. Journal of Chemical Biology 1, 49-62 doi:10.1007/s12154-008-0008-0.
    • Hailes, H. C., Behrendt, J. M. (2008). Oxetanes and Oxetenes. In Katritsky, A. R., Ramsden, C. A., Scriven, E. F. V., Taylor, R. J. K. (Eds.). Comprehensive Heterocyclic Chemistry III ( pp.321-364). Elsevier.
    • Hibbert, E. G., Senussi, T., Smith, M. E. B., Costelloe, S. J., Ward, J. M., Hailes, H. C., Dalby, P. A. (2008). Directed evolution of transketolase substrate specificity towards an aliphatic aldehyde. Journal of Biotechnology 134, 240-245 doi:10.1016/j.jbiotec.2008.01.018.
    • Hurley, C. A., Wong, J. B., Ho, J., Writer, M., Irvine, S. A., Lawrence, M. J., Hart, S. L., Tabor, A. B., Hailes, H. C. (2008). Mono- and dicationic short PEG and methylene dioxyalkylglycerols for use in synthetic gene delivery systems. Org.Biomol.Chem. 6(14), 2554-2559 Author URL
    • Irvine, S. A., Meng, Q. H., Afzal, F., Ho, J., Wong, J. B., Hailes, H. C., Tabor, A. B., McEwan, J. R., Hart, S. L. (2008). Receptor-targeted nanocomplexes optimized for gene transfer to primary vascular cells and explant cultures of rabbit aorta. Molecular Therapy 16, 508-515 doi:10.1038/sj.mt.6300381.
    • Kudsiova, L., Vassa, A., Hailes, H. C., Tabor, A. B. (2008). Uptake and intracellular trafficking of novel ternary lipoplexes for gene delivery. J PHARM PHARMACOL. ( Vol. 60 pp.A40-A40). PHARMACEUTICAL PRESS-ROYAL PHARMACEUTICAL SOC GREAT BRITIAN.
    • Lye, G. J., Baganz, F., Chen, B. H., Dlaby, P. A., Hailes, H. C., Hibbert, E., Kaulmann, U., Micheletti, M., Smith, M. E. B., Smithies, K., Ward, J. M., Woodley, J. M. (2008). Accelerating biocatalytic process design: Integrating new tools from biology, chemistry and engineering. BioFine 2008. Freiburg, Germany
    • Pilkington-Miksa, M. A., Sarkar, S., Writer, M. J., Barker, S. E., Shamlou, P. A., Hart, S. L., Hailes, H. C., Tabor, A. B. (2008). Synthesis of bifunctional integrin-binding peptides containing PEG spacers of defined length for non-viral gene delivery. European Journal of Organic Chemistry (17), 2900-2914 doi:10.1002/ejoc.200701188.
    • Pilkington-Miksa, M. A., Sarkar, S., Writer, M. J., Barker, S. E., Shamlou, P. A., Hart, S. L., Hailes, H. C., Tabor, A. B. (2008). Synthesis of bifunctional integrin-binding peptides containing PEG spacers of defined length for non-viral gene delivery. EUR J ORG CHEM (17), 2900-2914 doi:10.1002/ejoc.200701188.
    • Smith, M. E. B., Hibbert, E. G., Jones, A. B., Dalby, P. A., Hailes, H. C. (2008). Enhancing and Reversing the Stereoselectivity of Escherichia coli Transketolase via Single-Point Mutations. Advanced Synthesis and catalysis 350, 2631-2638 doi:10.1002/adsc.200800489.
    • Tagalakis, A. D., McAnulty, R. J., Devaney, J., Bottoms, S. E., Wong, J. B., Elbs, M., Writer, M. J., Hailes, H. C., Tabor, A. B., O'Callaghan, C., Jaffe, A., Hart, S. L. (2008). A receptor-targeted nanocomplex vector system optimized for respiratory gene transfer. Molecular Therapy 16, 907-915 doi:10.1038/mt.2008.38. Author URL
    • Tindal, S. R., Archer, I. V. J., Carr, R., Farid, S., Hailes, H. C., Woodley, J. M. (2008). Stability of amino acid oxidase in reactor scale-up. 7th European Symposium on Biochemical Engineering Science (ESBES-7). Faro, Portugal, September 7-10
    • Vareiro, M. M. L. M., Tranchant, I., Maplin, S., Zak, K., Gani, M. M., Slevin, C. J., Hailes, H. C., Tabor, A. B., Cameron, P. J., Jenkins, A. T. A., Williams, D. E. (2008). Surface plasmon resonance-enhanced fluorescence implementation of a single-step competition assay: Demonstration of fatty acid measurement using an anti-fatty acid monoclonal antibody and a Cy5-labeled fatty acid. Analytical Biochemistry 377(2), 243-250 doi:10.1016/j.ab.2008.03.033. Author URL
    • Wong, J. B., Grosse, S., Tabor, A. B., Hart, S. L., Hailes, H. C. (2008). Acid cleavable PEG-lipids for applications in a ternary gene delivery vector. Molecular Biosystems 4(6), 532-541 doi:10.1039/b719782a. Author URL

    2007

    • Baganz, F., Chen, B. H., Dalby, P. A., Hailes, H. C., Hibbert, E., Kaulmann, U., Lye, G. J., Micheletti, M., Smith, M. E. B., Smithies, K., Ward, J. M., and Woodley, J. M. (2007). Accelerating biocatalytic process design: Integrating new tools from biology, chemistry and engineering. Journal of Biotechnology 131, S78-S78
    • Baganz, F., Chen, B. H., Dalby, P. A., Hailes, H. C., Hibbert, E., Kaulmann, U., Lye, G. J., Micheletti, M., Smith, M. E. B., Smithies, K., Ward, J. M., and Woodley, J. M. (2007). Accelerating biocatalytic process design: Integrating new tools from biology, chemistry and engineering. Biochemical Engineering XV.
    • Bala, K., Hailes, H. C., Lafitte, V. G. H., Aliev, A., Golding, P. (2007). Supramolecular Polymers Prepared Starting from Hydrogen Bonded Cytosine-Based Modules. Author URL Patent 2007072000
    • Coward, L. S., M E B, H., E, W., J M, H., H C, A. D., P, A. (2007). Chemoenzymatic Synthesis of Structurally Diverse Compounds. 8th International Symposium on Biocatalysis and Biotransformations..
    • Hailes, H. C. (2007). Reaction solvent selection: The potential of water as a solvent for organic transformations. Organic Process Research & Development 11(1), 114-120 doi:10.1021/op060157x.
    • Hailes, H. C., Dalby, P. A. A. W., J, M. (2007). Integration of biocatalytic conversions into chemical syntheses. Journal of Chemical Technology and Biotechnology 82(12), 1063-1066 doi:10.1002/jctb.1763.
    • Hart, S. L., Grosse, S., Tabor, A. B., Wong, J. B., Elbs, M., Hailes, H. C., Mustapa, M. F. M. (2007). Preparation of Peptides and Lipids and their Complexes for the Delivery of Biologically Active Material to Cells. Patent 2007138324
    • Hervé, A. -. C., Carlisle, S., Lowe, P., Slevin, C. J., Forssten, C., Dilleen, J., Bhalla, R., Williams, D. E., Tranchant, I., Tabor, A. B., Hailes, H. C. (2007). Erratum: Design and synthesis of ferrocene probe molecules for detection by electrochemical methods (Bioconjugate Chemistry (2006) 17, 5). Bioconjugate Chemistry 18(6), 2203-2203 doi:10.1021/bc700366d.
    • Hibbert, E. G., Senussi, T., Costelloe, S. J., Lei, W., Smith, M. E. B., Ward, J. M., Hailes, H. C., Dalby, P. A. (2007). Directed evolution of transketolase activity on non-phosphorylated substrates. Journal of Biotechnology 131(4), 425-432 doi:10.1016/j.jbiotec.2007.07.949. Author URL
    • Hibbert, E. G., Senussi, T., Costelloe, S. J., Lei, W., Smith, M. E. B., Ward, J. M., Hailes, H. C., Dalby, P. A. (2007). Directed evolution of transketolase substrate specificity towards an aliphatic aldehyde. Journal of Biotechnology (134), 240-245 doi:10.1016/j.jbiotec.2008.01.018. Author URL
    • Hibbert, E. G., Smith, M. E. B., Smithies, K., Kaulmann, U., Hailes, H. C., Ward, J. M., Dalby, P. A. (2007). . European Symposium of the Protein Society. Stockholm, Sweden
    • Hibbert, E. G., Smith, M. E. B., Smithies, K., Kaulmann, U., Hailes, H. C., Ward, J. M., Dalby, P. A. (2007). Comparison of the natural and directed evolution of transketolase. European Protein Society. Stockholm, Sweden
    • Ingram, C. U., Bommer, M., Smith, M. E. B., Dalby, P. A., Ward, J. M., Hailes, H., Lye, G. J. (2007). One-pot synthesis of amino-alcohols using a de-novo transketolase and beta-alanine: Pyruvate transaminase pathway in Escherichia coli. Biotechnology and Bioengineering 96, 559-569 doi:10.1002/bit.21125.
    • Kaulmann, U., Smithies, K., Mark E B, S., M E B, H., H C, W., JM, (2007). Substrate spectrum of ω-transaminase from Chromobacterium violaceum DSM30191 and its potential for biocatalysis. Enzyme and Microbial Technology 41(5), 628-637 doi:10.1016/j.enzmictec.2007.05.01.
    • Kaulmann, U., Smithies, K., Smith, M. E. B., HaileS, H. C., Ward, J. M. (2007). Substrate spectrum of omega-transaminase from Chromobacterium violaceum DSM30191 and its potential for biocatalysis. ENZYME MICROB TECH 41(5), 628-637 doi:10.1016/j.enzmictec.2007.05.011.
    • Mustapa, F. M., Bell, P. C., Hurley, C. A., Nicol, A., Guénin, E., Sarkar, S., Writer, M. J., Barker, S. E., Wong, J. B., Pilkington-Miksa, M. A., Papahadjopoulos-Sternberg, B., Shamlou, P. A., Hailes, H. C., Hart, S. L., Zicha, D., Tabor, A. B. (2007). Biophysical characterisation of an integrin-targeted lipopolyplex gene delivery vector. Biochemistry 46(45), 12930-12944 doi:10.1021/bi701014y.
    • Mustapa, M. F., Bell, P. C., Hurley, C. A., Nicol, A., Guénin, E., Sarkar, S., Writer, M. J., Barker, S. E., Wong, J. B., Pilkington-Miksa, M. A., Papahadjopoulos-Sternberg, B., Shamlou, P. A., Hailes, H. C., Hart, S. L., Zicha, D., Tabor, A. B. (2007). Biophysical characterization of an integrin-targeted lipopolyplex gene delivery vector. Biochemistry 46(45), 12930-12944 doi:10.1021/bi701014y. Author URL
    • Pilkington-Miksa, M. A., Writer, M. J., Sarkar, S., Meng, Q. H., Barker, S. E., Shamlou, P. A., Hailes, H. C., Hart, S. L., Tabor, A. B. (2007). Targeting lipopolyplexes using bifunctional peptides incorporating hydrophobic Spacer amino acids: Synthesis, transfection, and biophysical studies. Bioconjugate Chemistry 18(6), 1800-1810 doi:10.1021/bc0700943. Author URL
    • Tranchant, I., Herve, A. C., Carlisle, S., Lowe, P., Slevin, C. J., Forssten, C., Dilleen, J., Tabor, A. B., Williams, D. E., Hailes, H. C. (2007). Applications of tailored ferrocenyl molecules as electrochemical probes of biochemical interactions. Bioconjugate Chemistry 18(1), 199-208 doi:10.1021/bc060039e. Author URL
    • Tranchant, I., Herve, A. C., Carlisle, S., Lowe, P., Slevin, C. J., Forssten, C., Dilleen, J., Williams, D. E., Tabor, A. B., Hailes, H. C. (2007). Design and synthesis of ferrocene probe molecules for detection by electrochemical methods (Vol 17, pg 1256, 2006). BIOCONJUGATE CHEM 18(6), 2203-2203

    2006

    • Hailes, H. C., Smith, M. E. B., Smithies, K., Dalby, P. A., Ward, J. M., Woodley, J. M. (2006). Chemoenzymatic synthesis of amniodiols: Engineering and directed evolution of biocatalytic pathways. Catalysis and Biocatalysis in Green Chemistry Conference. Cambridge
    • Hailes, H. C., Smith, M. E. B., Smithies, K., Hibbert, E. G., Kaulmann, U., Senussi, T. O., Costelloe, S., Dalby, P. A., Ward, J. M., Woodley, (2006). Ketodiol and aminodiol synthesis. Biocatalysis Gordon Research Conference. Smithfield, LI, USA
    • Hailes, H. C., Woodley, J. M. (2006). Biocatalytic reaction development for synthetic chemistry. Chemistry Today 24, 3-4
    • Ingram, C. U., Bommer, M., Smith, M. E. B., Dalby, P. A., Ward, J. M., Hailes, H., Lye, G. J. (2006). One-pot synthesis of amino-alcohols using a de-novo transketolase and beta-alanine: pyruvate transaminase pathway in Escherichia coli. Biotechnology and Bioengineering 96, 559-569 doi:10.1002/bit.21125. Author URL
    • Lafitte, V. G. H., Aliev, A. E., Horton, P. N., Hursthouse, M. B., Bala, K., Golding, P., Hailes, H. C. (2006). Quadruply hydrogen bonded cytosine modules for supramolecular applications. Journal of the American Chemical Society 128(20), 6544-6545 doi:10.1021/ja0587289. Author URL
    • Lafitte, V. G. H., Aliev, A. E., Horton, P. N., Hursthouse, M. B., Hailes, H. C. (2006). Highly stable cyclic dimers based on non-covalent interactions. Chemical Communications (20), 2173-2175 doi:10.1039/b600459h. Author URL
    • Smith, M. E. B., Smithies, K., Hibbert, E. G., Kaulmann, U., Senussi, T., Costelloe, S., Hailes, H. C., Dalby, P. A., Ward, J. M., Woodley, J. M. (2006). Biocatalytic and organocatalytic approaches to ketodiols and aminodiols. IUPAC International Conference of Biodiversity and Natural Products. Kyoto, Japan
    • Smith, M. E. B., Smithies, K., Senussi, T., Dalby, P. A., Hailes, H. C. (2006). The first mimetic of the transketolase reaction. European Journal of Organic Chemistry 2006(5), 1121-1123 doi:10.1002/ejoc.200500986.
    • Smith, M. E., Kaulmann, U., Ward, J. M., Hailes, H. C. (2006). A colorimetric assay for screening transketolase activity. Bioorganic and Medicinal Chemistry 14(20), 7062-7065 doi:10.1016/j.bmc.2006.06.008. Author URL
    • Smithies, K., Kaulmann, U., Smith, M. E. B., Ward, J. M., Woodley, J. M., Hailes, H. C. (2006). Combining organocatalysis and enzyme catalysis: Carbon-carbon bon formation followed by amination. International symposium on Organocatalysis in Organic Synthesis. Glasgow
    • Tranchant, I., Herve, A. C., Carlisle, S., Lowe, P., Slevin, C. J., Forssten, C., Dilleen, D., Williams, D. E., Tabor, A. B., Hailes, H. C. (2006). Design and synthesis of ferrocene probe molecules for detection by electrochemical methods. Bioconjugate Chemistry 17(5), 1256-1264 doi:10.1021/bc060038m. Author URL
    • Woscholski, R., Hailes, H., Numbere, M., Rosivatz, E. (2006). Substituted Phenols and Related Compounds, and their Preparation, Pharmaceutical Compositions and use for Modulating PKB Activity. Patent 2006097744
    • Writer, M., Hurley, C. A., Sarkar, S., Copeman, D. M., Wong, J. B., Odlyha, M., Jayne Lawrence, M., Tabor, A. B., McAnulty, R. J., Ayazi Shamlou, P., Hailes, H. C., Hart, S. L. (2006). Analysis and optimization of the cationic lipid component of a lipid/peptide vector formulation for enhanced transfection in vitro and in vivo. J Liposome Res 16(4), 373-389 doi:10.1080/08982100600992500. Author URL
    • Writer, M., Hurley, C. A., Sarkar, S., Copeman, D. M., Wong, J. B., Odlyha, M., Jayne, L. M., Tabor, A. B., McAnulty, R. J., Ayazi, S. P., Hailes, H. C., Hart, S. L. (2006). Analysis and optimization of the cationic lipid component of a lipid/peptide vector formulation for enhanced transfection in vitro and in vivo. J Liposome Res. 16(4), 373-389 Author URL

    2005

    • Bala, K., Hailes, H. C. (2005). Nitrile oxide 1,3-dipolar cycloadditions in water: Novel isoxazoline and cyclophane synthesis. Synthesis , 3423-3427 doi:10.1055/s-2005-918471.
    • Behrendt, J., Hailes, H. C., Bala, K., Golding, P. (2005). Oxetane synthesis via cyclisation of aryl sulfonate esters on polystyrene and PEG polymeric supports. TETRAHEDRON LETTERS 46(4), 643-645 doi:10.1016/j.tetlet.2004.11.138.
    • Caumul, P., Hailes, H. C. (2005). Baylis-Hillman reactions in aqueous acidic media. TETRAHEDRON LETTERS 46(47), 8125-8127 doi:10.1016/j.tetlet.2005.09.130.
    • Costelloe, S. J., Senussi, T., Hibbert, E. G., Smith, M. E. B., Hailes, H. C., Ward, J. M., Dalby, P. A. (2005). Evolution and engineering of transketolase substrate specificity. Biochemical Society - Biocatalysis: Enzymes, Mechanisms and Bioprocesses. Manchester, UK
    • Hailes, H. C., Smith, M. E. B., Smithies, K., Dalby, P. A., Ward, J. M., Woodley, J. M. (2005). Chemoenzymatic synthesis of amniodiols: Engineering and directed evolution of biocatalytic pathways. Catalysis and Biocatalysis in Green Chemistry. Cambridge
    • Hailes, H. C., Tabor, A. B., Wong, J. B., Pilkington-Miksa, M., Hart, S. L., Hurley, C. A. (2005). Preparation of Quaternary Ammonium Lipids and their Complexation with Peptides for Delivery to Cells. Patent 20050245446
    • Hibbert, E. G., Baganz, F., Hailes, H. C., Ward, J. M., Lye, G. J., Woodley, J. M., Dalby, P. A. (2005). Directed evolution of biocatalytic processes. Biomolecular Engineering 22(1-3), 11-19
    • Ingram, C. U., Lye, G. J., Dalby, P. A., Ward, J. M., Bommer, M., Hailes, H. C., Smith, M. E. B. (2005). Multistep biocatalytic pathways in bacteria for the synthesis of amniodiols. Biochemical Engineering Research Network. Birmingham, UK
    • Lafitte, V. G. H., Aliev, A., Hailes, H. C., Bala, K., Golding, P. (2005). Ureidopyrimidinones incorporating a functionalizable p-aminophenyl electron-donating group at C-6. Journal of Organic Chemistry 70, 2701-2707 Author URL
    • Lafitte, V. G., Aliev, A. E., Hailes, H. C., Bala, K., Golding, P. (2005). Ureidopyrimidinones incorporating a functionalizable p-aminophenyl electron-donating group at C-6. J Org Chem 70(7), 2701-2707 doi:10.1021/jo048223l. Author URL
    • Micheletti, M., Gill, N., Chen, B. H., Dalby, P. A., Baganz, F., Hailes, H. C., Ward, J. M., Lye, G. J., Woodley, J. M. (2005). Faster development and evaluation of biocatalytic processes. Faster Process Development: New Tools for New Challenges. London, UK
    • Numbere, M. G., Hailes, H. C., Rosivatz, E., Byrne, R., Woscholski, R. (2005). Synthetic approach to compound 48/80 and its analogues. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY. ( Vol. 229 pp.U129-U130). AMER CHEMICAL SOC.
    • Sarkar, S., Lee, L. K., Hart, S. L., Hailes, H. C., Levy, S. M., Tabor, A. B., Azayi Shamlou, P. (2005). Fractal Structure of Polycation-DNA Complexes. Biotechnology and Applied Biochemistry 41, 127-136
    • Sarkar, S., Lee, L. K., Hart, S. L., Hailes, H. C., Levy, S. M., Tabor, A., Shamlou, P. A. (2005). The fractal structure of polycation-DNA complexes. Biotechnol Appl Biochem 41(Pt 2), 127-136 doi:10.1042/BA20040017. Author URL
    • Smith, M. E. B., Ingram, C. U., Faulkner, S., Hibbert, E., Micheletti, M., Kaulmann, K., Hailes, H., Lye, G. J., Dalby, P. A., Ward, J. M., Woodley, J. M., Baganz, F. (2005). Engineering and directed evolution of multi-step biocatalytic pathways in bacteria. Third International Taylor Conference: "Catalysis at the Interface: Challanges and Opportunities. Belfast
    • Wong, J. B., Writer, M., Irvine, S., Tabor, A. B., Hart, S. L., Hailes, H. C. (2005). Role of cationic lipids in a non-viral lipid/peptide/DNA (LID) delivery system. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY. ( Vol. 230 pp.U549-U550). AMER CHEMICAL SOC.
    • Wosholski, R., Hailes, H. C., Numbere, M. G. (2005). Preparation of phenol oligomers as Inhibitors and/Activators of Protein Kinase B (PKB/Akt). Patent 205023744

    2004

    • Colston, M. J., Hailes, H. C., Stavropoulos, E., Hervé, A. C., Hervé, G., Goodworth, K. J., Hill, A. M., Jenner, P., Hart, P. D., Tascon, R. E. (2004). Antimycobacterial calixarenes enhance innate defense mechanisms in murine macrophages and induce control of Mycobacterium tuberculosis infection in mice. Infection and Immunity 72, 6318-6323
    • Harvey, H. G., Hervé, A. C., Hailes, H. C., Attfield, M. P. (2004). Synthesis, crystal structures, and modifications of novel framework gallium diphosphonates. Chemistry of Materials 16, 3756-3766
    • Hurley, C. A., Wong, J. B., Hailes, H. C., Tabor, A. B. (2004). Asymmetric synthesis of dialkyloxy-3-alkylammonium cationic lipids. J ORG CHEM 69, 980-983
    • Writer, M. J., Marshall, B., Pilkington-Miksa, M. A., Barker, S. E., Jacobsen, M., Bell, P. C., Lester, D. H., Tabor, A. B., Hailes, H. C., Klein, N., Hart, S. L. (2004). Targeted gene delivery to human airway epithelial cells with synthetic vectors incorporating novel targeting peptides selected by phage display. Journal of Drug Targeting 12(4), 185-193

    2003

    • Hailes, H. C., Isaac, B., Javaid, M. H. (2003). The synthesis of 2-alkylated cyclopentene-1,3-diones: Novel compounds with olfactory properties. Synthetic Communications 33, 29-41
    • Herve, G., Hahn, D. U., Hailes, H. C., Herve, A. C., Goodworth, K. J., Hill, A. M. (2003). The selective functionalisation and difunctionalisation of p-substituted calix[6]arene and calix[8]arenes using hydrophilic moieties. Organic and Biomolecular Chemistry 1, 427-435 doi:10.1039/b208649m.
    • Hurley, C. A., Hailes, H. C., Tabor, A. B., Hart, S. L. (2003). Complexes for the Delivery of Biologically-Active Material to Cells. Patent 2003094974
    • Ingram, C. U., Dalby, P. A., Hailes, H. C., Lye, G. J., Ward, J. (2003). Engineering and directed evolution of multi-step biocatalytic pathways in bacteria. 11th European Congress on Biotechnology. Basel, Switzerland
    • Ingram, C. U., Dalby, P. A., Hailes, H. C., Lye, G. J., Ward, J. (2003). Engineering and directed evolution of multi-step biocatalytic pathways in bacteria. Enzyme Engineering XVII. Santa Fe, New Mexico, USA
    • Pilkington-Miksa, M. A., Tabor, A. B., Hailes, H. C., Hart, S. L., Writer, M., Shamlou, P. A., Sarkar, S. (2003). Synthesis of unusual integrin-binding peptides for inclusion into LID transfection complexes. MOLECULAR THERAPY. ( Vol. 7 pp.S217-S218). ACADEMIC PRESS INC ELSEVIER SCIENCE.
    • Pilkington-Miksa, M. A., Tabor, A. B., Hart, S. L., Hailes, H. C., Writer, M., Shamlou, P. A., Sarkhar, S. (2003). Synthesis of Unusual Integrin-Binding Peptides for Inclusion into LID Transfection Complexes. Molecular Therapy. ( Vol. 3 pp.S217-S217).
    • Sarkar, S., Zhang, H., Hart, S. L., Hailes, H. C., Tabor, A. B., Shamlou, P. A. (2003). Prediction of size distribution of lipid-peptide-DNA vector particles using Monte Carlo simulation techniques. Biotechnology and Applied Biochemistry 38, 95-102
    • Sarkar, S., Zhang, H., Levy, M. S., Hart, S. L., Hailes, H. C., Tabor, A. B., Shamlou, P. A. (2003). Impact of biophysical and chemical properties of non-viral vector formulation on cell transfection. AIChE Annual Conference. San Francisco
    • Sarkar, S., Zhang, H., Levy, S. M., Hart, S. L., Hailes, H. C., Tabor, A. B., Shamlou, P. A. (2003). Prediction of size distribution of lipid-peptide-DNA vector particles using Monte Carlo simulation techniques. BIOTECHNOL APPL BIOC 38, 95-102

    2002

    • Hailes, H. C. (2002). The Synthesis of Fragrant Cyclopentane Systems. Advances in Flavours and Fragrances. In Swift, K. A. D. (Ed.). From the Sensation to the Synthesis ( pp.127-137). RSC Press.

    2001

    • Diego-Castro, M. J., Hailes, H. C., Lawrence, M. J. (2001). Synthesis and characterization of optically active surfactants derived from phenylalanine and leucine. Journal of Colloid and Interface Science 234(1), 122-126 doi:10.1006/jcis.2000.7285.
    • Forssten, C., Kontturi, K., Murtomaki, L., Hailes, H. C., Williams, D. E. (2001). An electrochemically driven two-phase S(N)2 reaction. Electrochemistry Communications 3(8), 379-383 doi:10.1016/S1388-2481(01)00169-2.
    • Guenin, E., Tabor, A. B., Hurley, C. A., Hailes, H. C., Hart, S. L. (2001). Synthesis of labelled peptides for the study of gene delivery system. Molecular Therapy. ( Vol. 3 pp.S203-).
    • Hailes, H. C., Hurley, C. A., Tabor, A. B., Hart, S. L. (2001). The Synthesis of Cationic Lipids: Investigations into non-viral Lipid/Peptide/DNA transfection vector. Molecular Therapy. ( Vol. 3 pp.S204-).
    • Hailes, H. C., Isaac, B., Javaid, M. H. (2001). 1,4-addition of chiral 2-propenylphosphonamide anions to alpha-substituted cyclopentenones: use in enantioselective syntheses of methyl dihydrojasmonates and methyl jasmonates. Tetrahedron Letters 42(41), 7325-7328 doi:10.1016/S0040-4039(01)01437-X.
    • Hailes, H. C., Isaac, B., Javaid, M. H. (2001). Synthesis of methyl epijasmonate and cis-3-(2-oxopropyl)-2-(pent-2Z-enyl)-cyclopentan-1-one. Tetrahedron 57(52), 10329-10333 doi:10.1016/S0040-4020(01)01059-6.

    2000

    • Hailes, H. C. (2000). Royal Society of Chemistry and the Biochemical Society's International Symposium on Functional Genomics: From gene to commercial reality? September 19-22, 1999, Ambleside, UK. Expert Opin Investig Drugs 9(1), 173-179 doi:10.1517/13543784.9.1.173. Author URL
    • Hailes, H. C. (2000). Royal society of shemistry & the biochemical society's international symposium on functional genomics: from gene to commercial reality? EXPERT OPINION IN INVESTIGATIONAL DRUGS 9, 173-

    1999

    • Hailes, H. C., Madden, J. (1999). Novel recyclable aminoalcohol salts in catalytic asymmetric inductions. The addition of diethylzinc to aromatic aldehydes. Synlett , 105-107 doi:10.1055/s-1999-2541.

    1998

    • Diego-Castro, M. J., Hailes, H. C. (1998). Novel application of chiral micellar media to the Diels-Alder reaction. Chemical Communications , 1549-1550 doi:10.1039/a802825g.
    • Diego-Castro, M. J., Hailes, H. C. (1998). Studies on the use of surfactants in aqueous Diels-Alder reactions. Tetrahedron Letters 39(15), 2211-2214 doi:10.1016/S0040-4039(98)00177-4.

    1995

    • DENHOLM, A. A., GEORGE, M. H., HAILES, H. C., TIFFIN, P. J., WIDDOWSON, D. A. (1995). THE SYNTHESIS OF PRECISELY STRUCTURED POLYURETHANES .1. MONOMER SYNTHESIS. J CHEM SOC PERK T 1 (5), 541-547