Dr Derek Macmillan - Publications


    • Shariff, L., Cowper, B., Macmillan, D., Zhu, Y., Di, W. -. L. (2014). Sunflower trypsin inhibitor (SFTI-1) analogues of synthetic and biological origin via N→S acyl transfer: potential inhibitors of human Kallikrein-5 (KLK5). Tetrahedron doi:10.1016/j.tet.2014.06.059.


    • Adams, A. L., Macmillan, D. (2013). Investigation of peptide thioester formation via N -> Se acyl transfer. J Pept Sci 19(2), 65-73 doi:10.1002/psc.2469. Author URL
    • Adams, A. L., Srai, S. K., Macmillan, D. (2013). Hepcidin, a Challenging Arena for Developing New Ligation Methodology. BIOPOLYMERS. ( Vol. 100 pp.311-312). Author URL
    • Cowper, B., Craik, D. J., Macmillan, D. (2013). Chemically-mediated Circularisation of Recombinant Proteins. BIOPOLYMERS. ( Vol. 100 pp.226-226). Author URL
    • Cowper, B., Craik, D. J., Macmillan, D. (2013). Making Ends Meet: Chemically Mediated Circularization of Recombinant Proteins. Chembiochem 14(7), 809-812 doi:10.1002/cbic.201300105. Author URL
    • Currie, S. M., Findlay, E. G., McHugh, B. J., Mackellar, A., Man, T., Macmillan, D., Wang, H., Fitch, P. M., Schwarze, J., Davidson, D. J. (2013). The Human Cathelicidin LL-37 Has Antiviral Activity against Respiratory Syncytial Virus. PLOS ONE 8(8), ARTN e73659 doi:10.1371/journal.pone.0073659. Author URL
    • Macmillan, D. (2013). Cysteine promoted C-terminal hydrazinolysis of native peptides and proteins. doi:10.1002/anie.201304997.


    • Harvey, S. R., Porrini, M., Stachl, C., MacMillan, D., Zinzalla, G., Barran, P. E. (2012). Small-Molecule Inhibition of c-MYC:MAX Leucine Zipper Formation Is Revealed by Ion Mobility Mass Spectrometry. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 134(47), 19384-19392 doi:10.1021/ja306519h. Author URL
    • Jungmichel, S., Clapperton, J. A., Lloyd, J., Hari, F. J., Spycher, C., Pavic, L., Li, J., Haire, L. F., Bonalli, M., Larsen, D. H., Lukas, C., Lukas, J., MacMillan, D., Nielsen, M. L., Stucki, M., Smerdon, S. J. (2012). The molecular basis of ATM-dependent dimerization of the Mdc1 DNA damage checkpoint mediator. Nucleic Acids Research 40(9), 3913-3928 doi:10.1093/nar/gkr1300.


    • Adams, A., Macmillan, D. (2011). Peptide Thioesters via N -> Se Acyl Transfer. BIOPOLYMERS. ( Vol. 96 pp.437-437). WILEY-BLACKWELL.
    • Hirano, K., Izumi, M., Macmillan, D., Tezuka, K., Tsuji, T., Kajihara, Y. (2011). Semisynthesis of Erythropoietin Analog Having Three Oligosaccharides. JOURNAL OF CARBOHYDRATE CHEMISTRY 30(4-6), 306-319 doi:10.1080/07328303.2011.604570. Author URL
    • Kajihara, Y., Izumi, M., Hirano, K., Murase, T., Macmillan, D., Okamoto, R. (2011). Elucidating the Function of Complex-Type Oligosaccharides by Use of Chemical Synthesis of Homogeneous Glycoproteins. ISRAEL JOURNAL OF CHEMISTRY 51(8-9), 917-929 doi:10.1002/ijch.201100081. Author URL
    • Macmillan, D., Adams, A., Premdjee, B. (2011). Shifting native chemical ligation into reverse through N→S acyl transfer. ISRAEL JOURNAL OF CHEMISTRY 51(8-9), 885-899 doi:10.1002/ijch.201100084. Author URL
    • Macmillan, D., De Cecco, M., Reynolds, N. L., Santos, L. F., Barran, P. E., Dorin, J. R. (2011). Synthesis of Cyclic Peptides through an Intramolecular Amide Bond Rearrangement. Chembiochem 12(14), 2133-2136 doi:10.1002/cbic.201100364. Author URL
    • Premdjee, B., Adams, A. L., Macmillan, D. (2011). Native N-glycopeptide thioester synthesis through N -> S acyl transfer. Bioorg Med Chem Lett 21(17), 4973-4975 doi:10.1016/j.bmcl.2011.05.059. Author URL
    • Richardson, J. P., Macmillan, D. (2011). Semi-synthesis of glycoproteins from E. coli through native chemical ligation. In Evans, T. C., Xu, M. -. Q. (Eds.). Heterologous Gene Expression in E.coli (1st ed. Vol. 705 pp.151-174).


    • Ackrill, T., Anderson, D. W., Macmillan, D. (2010). Towards Biomolecular Assembly Employing Extended Native Chemical Ligation in Combination With Thioester Synthesis Using an N -> S Acyl Shift. Biopolymers 94(4), 495-503 doi:10.1002/bip.21473. Author URL
    • De Cecco, M., Seo, E. S., Clarke, D. J., McCullough, B. J., Taylor, K., Macmillan, D., Dorin, J. R., Campopiano, D. J., Barran, P. E. (2010). Conformational Preferences of Linear beta-Defensins Are Revealed by Ion Mobility-Mass Spectrometry. J PHYS CHEM B 114(6), 2312-2318 doi:10.1021/jp9111662.
    • Kang, J., Macmillan, D. (2010). Peptide and protein thioester synthesis via N -> S acyl transfer. Org Biomol Chem 8(9), 1993-2002 doi:10.1039/b925075a. Author URL
    • Masania, J., Li, J., Smerdon, S. J., Macmillan, D. (2010). Access to phosphoproteins and glycoproteins through semi-synthesis, Native Chemical Ligation and N -> S acyl transfer. Org Biomol Chem 8(22), 5113-5119 doi:10.1039/c0ob00363h. Author URL
    • McCullough, B. J., Kalapothakis, J. M., Chin, W., Taylor, K., Clarke, D. J., Eastwood, H., Campopiano, D., MacMillan, D., Dorin, J., Barran, P. E. (2010). Binding a heparin derived disaccharide to defensin inspired peptides: insights to antimicrobial inhibition from gas-phase measurements. PHYS CHEM CHEM PHYS 12(14), 3589-3596 doi:10.1039/b923784d.
    • Reynolds, N. L., Cecco, M. D., Taylor, K., Stanton, C., Kilanowski, F., Kalapothakis, J., Seo, E., Uhrin, D., Campopiano, D., Govan, J., Macmillan, D., Barran, P., Dorin, J. R. (2010). Peptide Fragments of a ß-Defensin Derivative With Potent Bactericidal Activity. Antimicrobial Agents and Chemotherapy 54(5), 1922-1929 doi:10.1128/AAC.01568-09.
    • Reynolds, N. L., De Cecco, M., Taylor, K., Stanton, C., Kilanowski, F., Kalapothakis, J., Seo, E., Uhrin, D., Campopiano, D., Govan, J., Macmillan, D., Barran, P., Dorin, J. R. (2010). Peptide Fragments of a beta-Defensin Derivative with Potent Bactericidal Activity. Antimicrob Agents Chemother 54(5), 1922-1929 doi:10.1128/AAC.01568-09. Author URL
    • Richardson, J. P., Chan, C. H., Blanc, J., Saadi, M., Macmillan, D. (2010). Exploring neoglycoprotein assembly through native chemical ligation using neoglycopeptide thioesters prepared via N -> S acyl transfer. Org Biomol Chem 8(6), 1351-1360 doi:10.1039/b920535g. Author URL
    • Tyrrell, C., De Cecco, M., Reynolds, N. L., Kilanowski, F., Campopiano, D., Barran, P., Macmillan, D., Dorin, J. R. (2010). Isoleucine/leucine(2) is essential for chemoattractant activity of beta-defensin Defb14 through chemokine receptor 6. MOL IMMUNOL 47(6), 1378-1382 doi:10.1016/j.molimm.2009.11.025.
    • Virdee, S., Macmillan, D., Waksman, G. (2010). Semisynthetic Src SH2 Domains Demonstrate Altered Phosphopeptide Specificity Induced by Incorporation of Unnatural Lysine Derivatives. Chemistry & Biology 17(3), 274-284 doi:10.1016/j.chembiol.2010.01.015.


    • Hirano, K., Macmillan, D., Tezuka, K., Tsuji, T., Kajihara, Y. (2009). Design and Synthesis of a Homogeneous Erythropoietin Analogue with Two Human Complex-Type Sialyloligosaccharides: Combined Use of Chemical and Bacterial Protein Expression Methods. ANGEW CHEM INT EDIT 48(50), 9557-9560 doi:10.1002/anie.200904376.
    • Kang, J., Reynolds, N. L., Tyrrell, C., Dorin, J. R., Macmillan, D. (2009). Peptide thioester synthesis through N -> S acyl-transfer: application to the synthesis of a beta-defensin. Org Biomol Chem 7(23), 4918-4923 doi:10.1039/b913886b. Author URL
    • Kang, J., Richardson, J. P., Macmillan, D. (2009). 3-Mercaptopropionic acid-mediated synthesis of peptide and protein thioesters. CHEM COMMUN (4), 407-409 doi:10.1039/b815888f.
    • Macmillan, D. (2009). 2,3,4-Trimethoxy-6-[[(4-methoxyphenyl)-methyl]thio]benzaldehyde. Encyclopedia of Reagents for Organic Synthesis doi:10.1002/047084289X.rn00970..
    • Taylor, K., Rolfe, M., Reynolds, N., Kilanowski, F., Pathania, U., Clarke, D., Yang, D., Oppenheim, J., Samuel, K., Howie, S., Barran, P., Macmillan, D., Campopian, D., Dorin, J. (2009). Defensin-related peptide 1 (Defr1) is allelic to Defb8 and chemoattracts immature DC and CD4(+) T cells independently of CCR6. EUR J IMMUNOL 39(5), 1353-1360 doi:10.1002/eji.200838566.


    • Karkkainen, T. S., Kartha, K. P. R., MacMillan, D., Field, R. A. (2008). Iodine and its interhalogen compounds: versatile reagent in carbohydrate chemistry. XX. Iodine-mediated glycosylation en route to mucin-related glyco-aminoacids and glycopeptides. CARBOHYD RES 343(10-11), 1830-1834 doi:10.1016/j.carres.2008.03.034.
    • Li, J., Taylor, I. A., Lloyd, J., Clapperton, J. A., Howell, S., MacMillan, D., Smerdon, S. J. (2008). Chk2 Oligomerization Studied by Phosphopeptide Ligation IMPLICATIONS FOR REGULATION AND PHOSPHODEPENDENT INTERACTIONS. J BIOL CHEM 283(51), 36019-36030 doi:10.1074/jbc.M804075200.
    • Macmillan, D., Blanc, J. (2008). Method of covalently linking a carbohydrate or polyalkylene oxide to a peptide, precursors for use in the method and resultant products. Patent WO2008001109
    • Marchesan, S., Macmillan, D. (2008). Chemoenzymatic synthesis of GDP-azidodeoxymannoses: non-radioactive probes for mannosyltransferase activity. CHEM COMMUN (36), 4321-4323 doi:10.1039/b807016d.
    • McCullough, B. J., Kalapothakis, J., Eastwood, H., Kemper, P., MacMillan, D., Taylor, K., Dorin, J., Barran, P. E. (2008). Development of an ion mobility quadrupole time of flight mass spectrometer. ANAL CHEM 80(16), 6336-6344 doi:10.1021/ac800651b.
    • Richardson, J. P., Macmillan, D. (2008). Optimisation of chemical protein cleavage for erythropoietin semi-synthesis using native chemical ligation. Org Biomol Chem 6(21), 3977-3982 doi:10.1039/b811501j. Author URL
    • Taylor, K., Clarke, D. J., McCullough, B., Chin, W., Seo, E., Yang, D., Oppenheim, J., Uhrin, D., Govan, J. R. W., Campopiano, D. J., MacMillan, D., Barran, P., Dorin, J. R. (2008). Analysis and separation of residues important for the chemoattractant and antimicrobial activities of beta-defensin 3. J BIOL CHEM 283(11), 6631-6639 doi:10.1074/jbc.M709238200.


    • Macmillan, D. (2006). Evolving strategies for protein synthesis converge on native chemical ligation. Angewandte Chemie International Edition 45(46), 7668-7672 doi:10.1002/anie.200602945.
    • Macmillan, D., Blanc, J. (2006). A novel neoglycopeptide linkage compatible with native chemical ligation. Organic and Biomolecular Chemistry 4, 2847-2850 doi:10.1039/b607200c. Author URL


    • Bloom, J. D., Meinhold, P., Meyer, M. M., Otey, C. R., Macmillan, D., Arnold, F. H. (2005). Evolving strategies for enzyme engineering. Curr. Opin Struct. Biol. 15, 447-452 doi:10.1016/j.sbi.2005.06.004.
    • Shirran, S., Garnaud, P., Daff, S., MacMillan, D., Barran, P. (2005). The formation of a complex between calmodulin and neuronal nitric oxide synthase is determined by ESI-MS. Journal of the Royal Society, Interface 2(5), 465-476 doi:10.1098/?rsif.2005.0055.


    • Lubna, A., Macmillan, D. (2004). Expressed protein ligation for the semi-synthesis of glycoproteins. PROTEIN SCIENCE. ( Vol. 13 pp.181-181). Author URL
    • Macmillan, D. (2004). Modular assembly of glycoproteins: Towards the synthesis of GlyCAM-1 by using expressed protein ligation. Angewandte Chemie International Edition 43, 1355-1359 doi:10.1002/anie.200352673.
    • Macmillan, D. (2004). Semi-synthesis of glycoproteins and mimetics using chemoselective ligations. GLYCOBIOLOGY. ( Vol. 14 pp.1179-1179). Author URL
    • Macmillan, D., Anderson, D. W. (2004). Rapid synthesis of acyl transfer auxiliaries for cysteine-free native glycopeptide ligation. Organic Letters 6(25), 4659-4662 doi:10.1021/ol048145o.
    • Macmillan, D., Arham, L. (2004). Cyanogen bromide cleavage generates fragments suitable for expressed protein and glycoprotein ligation. Journal of The American Chemical Society 126, 9530-9531 doi:10.1021/ja047855m. Author URL


    • Macmillan, D., Daines, A. M. (2003). Recent developments in the synthesis and discovery of oligosaccharides and glycoconjugates for the treatment of disease. Current Medicinal Chemistry 10(24), 2733-2773 doi:10.2174/0929867033456413.


    • Macmillan, D., Daines, A. M., Bayrhuber, M., Flitsch, S. L. (2002). Solid-phase synthesis of thioether-linked glycopeptide mimics for application to glycoprotein semisynthesis. ORGANIC LETTERS 4, 1467-1470 Author URL


    • Macmillan, D., Bill, R. M., Sage, K. A., Fern, D., Flitsch, S. L. (2001). Selective in vitro glycosylation of recombinant proteins: semi-synthesis of novel homogeneous glycoforms of human erythropoietin. Chemistry and Biology 8(2), 133-145 doi:10.1016/S1074-5521(00)90065-6.