Professor Alethea Tabor

Organic Chemistry and Chemical Biology

Prof Alethea Tabor

Address: Department of Chemistry, UCL
Phone No: +44 (0)20 7679 4695
Fax No: +44 (0)20 7679 7463
Extension: 24695
Photo of Alethea Tabor


Research areas of interest include:

  • Chemical Biology
  • Confirmationally constrained peptides
  • Lantibiotics
  • Non-viral gene therapy 

Summary

Alethea Tabor Research Image

Research in my laboratory covers a broad range of projects in chemical biology. The underlying theme is the use of synthetic organic chemistry to solve biological problems, by developing tools to peturb, modify and probe biological systems. The development of new synthetic methodology to solve the challenges posed by the synthesis of these molecules, and the use of a range of biophysical techniques to analyse their interactions with the target, are both important parts of ours research. Many of our projects are directed towards biological problems of therapeutic relevance, and we have an extensive network of interdisciplinary collaborations, within UCL, at other institutions, and with industry.

Research Profile

Selected Publications

  1. Sayer, J., Walldén, K., Pesnot, T., Campbell, F., Gane, P. F., Simone, M., Koss, H., Buelens, F., Boyle, T. P., Selwood, D. L., Waksman, G., Tabor, A. B. (2014) 2- and 3-substituted imidazo[1,2-a]pyrazines as inhibitors of bacterial type IV secretion. Bioorg Med Chem, 22, 6459-6470.
  2. Mitchell, N., Kalber, T. L., Cooper, M. S., Sunassee, K., Chalker, S. L., Shaw, K. P., Ordidge, K. L., Badar, A., Janes, S. M., Blower, P. J., Lythgoe, M. F., Hailes, H. C., Tabor, A. B. (2013). Incorporation of paramagnetic, fluorescent and PET/SPECT contrast agents into liposomes for multimodal imaging. Biomaterials 34, 1179-1192.
  3. Welser, K., Campbell, F., Kudsiova, L., Mohammadi, A., Dawson, N., Hart, S. L., Barlow, D. J., Hailes, H. C., Lawrence, M. J., Tabor, A. B. (2013). Gene delivery using ternary lipopolyplexes incorporating branched cationic peptides: The role of peptide sequence and branching. Mol Pharm 10, 127-141.
  4. Mothia, B., Appleyard, A. N., Wadman, S., Tabor, A. B. (2011). Synthesis of peptides containing overlapping lanthionine bridges on the solid phase: an analogue of rings D and E of the lantibiotic nisin. Org Lett 13, 4216-4219.
  5. Tabor, A. B. (2011). The challenge of the lantibiotics: synthetic approaches to thioether-bridged peptides. Org Biomol Chem 9, 7606-7628.
  6. Chaudhry, B. R., Wilton-Ely, J. D. E. T., Tabor, A. B., Caruana, D. J. (2010). Effect of peptide orientation on electron transfer. Phys Chem Chem Phys 12, 9996-9998.
  7. Raiber, E. A., Tulone, C., Zhang, Y., Martinez-Pomares, L., Steed, E., Sponaas, A. M., Langhorne, J., Noursadeghi, M., Chain, B. M., Tabor, A. B. (2010). Targeted delivery of antigen processing inhibitors to antigen presenting cells via mannose receptors. ACS Chem Biol 5, 461-476.
  8. Mustapa, M. F., Grosse, S. M., Kudsiova, L., Elbs, M., Raiber, E. A., Wong, J. B., Brain, A. P., Armer, H. E., Warley, A., Keppler, M., Ng, T., Lawrence, M. J., Hart, S. L., Hailes, H. C., Tabor, A. B. (2009). Stabilized Integrin-Targeting Ternary LPD (Lipopolyplex) Vectors for Gene Delivery Designed To Disassemble Within the Target Cell. Bioconj Chem 20, 518-532.

All Publications

1982-1985: B. A. (Natural Sciences) (Hons) St. Catharine's College, Cambridge

1985-1989: Ph. D. University of Cambridge, Professor A. B. Holmes FRS

1987-1989: Denman Baynes Fellowship, Clare College , Cambridge

1989-1991: NATO Postdoctoral Fellowship, Harvard University , Professor S. L. Schreiber

1991-1994: Lecturer, Department of Chemistry, University of Edinburgh

1994-2001: Lecturer, Department of Chemistry, University College London

2001-2004: Senior Lecturer, Department of Chemistry, University College London

2004-2012: Reader in Chemical Biology, University College London

2012 -       : Professor of Chemical Biology, University College London