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Dr Tom Sheppard

Organic Chemistry and Chemical Biology

Dr Tom Sheppard
Address: Department of Chemistry, UCL
Phone No: +44 (0)20 7679 2467
Fax No: +44 (0)20 7679 7463
Extension: 32467
Email: tom.sheppard@ucl.ac.uk
Website: www.tomsheppard.eu
Photo of Tom Sheppard

Research areas of interest include:

  • Catalysis
  • Three and Four Membered Rings
  • Synthetic Approaches to Medium Ring Systems
  • Multicomponent Reactions
  • Bio-orthogonal Reactions

Summary

Tom Sheppard Research Image

Our research is focussed on the development of new methods for organic synthesis. In all cases, the research projects seek to provide novel solutions to challenging chemical problems, which will facilitate the synthesis of small, highly functionalised organic molecules with potential applications in drug discovery or chemical biology.

Research Profile

Selected Publications

  1. An Alternative Approach to Aldol Reactions: Gold-Catalyzed Formation of Boron Enolates from Alkynes , C. Körner, P. Starkov, T. D. Sheppard, Journal of the American Chemical Society 2010, 132, 5968.doi:10.1021/ja102129c
  2. Metal-catalysed halogen exchange reactions of aryl halides , T. D. Sheppard, Organic and Biomolecular Chemistry 2009, 7, 1043. doi:10.1039/b818155a
  3. Intramolecular amidocyclopropanation reactions using diethoxymethyl-functionalised lactams as organozinc carbenoid precursors , L. Jerome, T. D. Sheppard, A. E. Aliev, W. B. Motherwell, Tetrahedron Letters 2009, 50, 3709. doi:10.1016/j.tetlet.2009.03.224
  4. Asymmetric synthesis of aminocyclopropanes and N-cyclopropylamino alcohols via direct amidocyclopropanation of alkenes using chiral organozinc carbenoids , G Bégis, D. Cladingboel, L. Jerome, W. B. Motherwell and T. D. Sheppard, European Journal of Organic Chemistry 2009, 1532.doi:10.1002/ejoc.200801033
  5. Isocyanide Based Multicomponent Reactions of Oxazolidines and Related Systems, R. Waller, L. J. Diorazio, B. A. Taylor, W. B. Motherwell and T. D. Sheppard, Tetrahedron 2010, submitted.

All Publications

  • 1995-1999 MSci Natural Sciences (Chemistry), University of Cambridge
  • 1999-2000 Research Scientist at GlaxoWellcome PLC, Stevenage and Cambridge
  • 2000-2004 PhD in Organic Chemistry with Professor Steven V. Ley, University of Cambridge
  • 2004-2007 Postdoctoral Researcher with Professor William B. Motherwell, University College London
  • 2007- EPSRC Advanced Research Fellow and Lecturer in Organic Chemistry, University College London