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Work from Prof Jim Anderson’s group has appeared as a Featured Article and on the front cover of J. Org. Chem.

17 May 2011

J. Anderson et al, J. Org. Chem., 2011, 76, 1961; DOI: 10.1021/jo102408u

The paper details the groups most recent developments of the nitro-Mannich reaction. In this paper the observation that the three-component coupling reaction between imines, nitro alkenes, and diakylzincs was heterogeneous in diethyl ether led to the formation of either of two diastereoisomers by judicious choice of solvent. The reaction forms 2 carbon-carbon bonds and controls 3 contiguous stereocentres in one reaction vessel.

see http://pubs.acs.org/doi/abs/10.1021/jo102408u for full details

James C. Anderson, Gregory J. Stepney, Matthew R. Mills, Lisa R. Horsfall, Alexander J. Blake and William Lewis

Enantioselective Conjugate Addition Nitro-Mannich Reactions: Solvent Controlled Synthesis of Acyclic anti- and syn-β-Nitroamines with Three Contiguous Stereocenters

J. Org. Chem., 2011, 76, pp 1961–1971

DOI: 10.1021/jo102408u