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Programme Administrator:

Amanda Kosinski

email: cgt [@] ucl.ac.uk

tel: +44 (0) 20 7905 2119

Cell

Next intake: September 2014

Application deadline extended to: 12th September 2014

Apply Now

Open Day: 19th November 2014

Open Day

Module Details

Foundations of Biomedical Sciences

Aims
  • To expose students (BSc and MBBS) to cutting-edge research in a wide-spectrum of Biomedical disciplines thus providing opportunities for students to hone in on the area of their own interest.
  • Detailed tutorials on practical and theoretical aspects of laboratory techniques and critical analysis, thus aiding the student in their subsequent research experience.
  • Active participation in 'Oral Presentation' of scientific papers to enhance presentational skills.

Molecular Aspects of Cell and Gene Therapy

Compulsory (15 Credits)



The aim of this module is to teach the students the basic scientific concepts which underlie cell and gene therapy clinical trials. It will introduce aspects of genetics, cell biology, virology, and immunology. In particular it will cover:

  • Gene regulation and expression
  • The design of vectors
  • Viral and non-viral vectors
  • Other gene delivery methods
  • Cell culture techniques
  • Transduction and transfection techniques
  • Cell separation techniques
  • Immune responses and epigenetics relevant to gene delivery
  • GMP techniques
  • Vector production
  • GMP facilities and regulations for clinical trials
  • Research aspects of cell and gene therapy

This module will be delivered mostly as a series of lectures by ICH/UCL staff with some external experts. There will be the opportunity for students to attend additional ICH/UCL research seminars and also an external symposium, the Annual Meeting of the British Society for Gene Therapy, where they will have opportunity to attend additional education sessions and seminars by international experts (though this is not compulsory).

Students are expected to invest significant time to self-study outside of class meetings.

Distribution of learning hours

Work Learning hours
Lectures 30
Private reading 70
Seminars / problem classes / tutorials 10
Revision 35
In class exam 3
Module evaluation 2
Total learning hours 150


Clinical Applications of Cell and Gene Therapy

Compulsory (15 Credits)



The aim of this module is to teach the students the historic, current and future cell and gene therapy treatment strategies. It will introduce concepts in clinical and basic research, clinical trials and methodology. In particular it will cover:

  • Principles of stem cell transplantation, including bone marrow transplantation
  • Rationale for treating particular diseases by cell and gene therapy
  • Principles and practice of clinical trials of cell therapy, including stem cell transplantation, immunotherapy and gene therapy
  • Discussion of ethics, regulation and monitoring required for such clinical studies

This module will be delivered mostly as a series of lectures by ICH/UCL staff with some external experts. There will be the opportunity for students to attend additional ICH/UCL research seminars and also an external symposium, the Annual Meeting of the British Society for Gene Therapy, where they will have opportunity to attend additional education sessions and seminars by international experts (though this is not compulsory).

Distribution of learning hours



Work Learning hours
Lectures 30
Private reading 70
Seminars / problem classes / tutorials 10
Revision 35
In class assessment (exam) 3
Module evaluation 2
Total learning hours 150

Research Methodology and Statistics

Module Lead: Dr Angie Wade

Compulsory 15 Credits

Aims

  • Students will become familiar with and competent in:
  • Summarising data: Means, medians and measures of spread
  • Displaying data: Why and how.
  • The normal distribution and normal tables
  • Making inferences: significance testing and confidence intervals. Paired and unpaired t-tests.
  • Non-parametric analyses
  • Serial measurements, one-way ANOVA
  • Analysis of categoric data
  • Assessing reliability and validity
  • SPSS

Outline

We will introduce students to the basic concepts of study design, data presentation and analysis as utilised within Child Health. And provide them with the tools to effectively read and interpret published paediatric research and to undertake their own research studies. Designing research studies: includes collecting data, allocation/randomisation procedures, blinding, confounding and protocol writing.

Method of assessment

2.5 hour computer based exam (best single answer, short open ended and SPSS based questions)

Applied Genomics

Optional (15 Credits)


This module aims to provide students with an up-to-date and broad knowledge of the principles of genomics, genomic technologies, methods of genomic analysis and the application of Genomics in medicine and life sciences.

The course will cover:

  • Principles of Genome investigation
  • Genomics technologies
  • Statistics for genomics
  • Gene Discovery (including sequence capture)
  • Population Genomics
  • Genome-wide regulation
  • Transcriptomics
  • Dynamic models and Networks
  • Analysis of genomic datasets
  • Basic computing for Genomics and exemplar applications

The aim is for students to leave with a full ability to design, run, analyse and understand genomic data.

The course will be delivered through lectures, workshops (practical analysis) and self-directed learning. As part of their independent course assessment students will be expected to undertake literature research, to design a genomic experiment and appropriately execute an analysis workflow to achieve a research outcome based on a genomic dataset.

Distribution of learning hours



Work Learning hours
Lectures 30
Private reading 60
Seminars / problem classes / tutorials 16
Revision 40
In class assessment 3
Module evaluation 1
Total learning hours 150

Stem Cells and Tissue Repair

Compulsory (15 Credits)


The module will introduce students to:

  • Basic stem cell biology
  • Induction of pluripotent stem cells
  • Cancer stem cells
  • Different sources of stem cells with potential for

    • i. Clinical applications aimed at repairing diseased or damaged tissues, including those due to birth defects
    • ii. Modeling human diseases

The importance of multidisciplinary approaches and regulatory and ethical issues concerning the use of stem cells will also be addressed.This module will be delivered mostly as a series of lectures given by basic scientists and clinicians based at ICH/UCL with some external experts. Students will be encouraged to attend additional research seminars, though this is not compulsory. Students will be expected to undertake research presentations to tutors and other students and will also be expected to undertake periods of self-study, as directed by the course tutor.

Distribution of learning hours



Work Learning hours
Lectures 30
Private reading 60
Seminars / problem classes / tutorials 12
Required written work 15
Preparation and execution of Powerpoint presentation 30
Module evaluation 3
Total learning hours 150



HIV Frontiers from Research to Clinics

15 credits, optional

Dr. Yasu Takeuchi

The aim of this 15-credit module is to gain, current, in-depth knowledge of HIV molecular biology, and its application in medicine. The module will cover the biology of HIV biology by exploring virus-host cell interaction, the infection history and pathogenesis of HIV in both cell and systemic levels, an up-to-date knowledge of the approaches and progress made in the development of HIV prevention and therapy, and the main principles of the clinical management of HIV infection.

Molecular and Genetic Basis of Paediatric Disease

Module Lead: Dr Hannah Mitchison

15 Credits

Aims

Students will learn to:

  • develop a working knowledge of DNA structure and function, disease inheritance patterns and methodologies for screening and identifying genetic defects
  • increase understanding of recent advances in molecular medicine and genetics and their impact upon everyday clinical practice.
  • appreciate how molecular and genetic technologies can lead to new treatment options.

Method of assessment

MCQ Exam and essay

Laboratory Methods in Biomedical Science

15 credits, optional

Dr Mona Bajaj-Elliott

The course will be delivered through lectures, interactive seminars and in visits to active laboratories where research and hospital diagnostic procedures are carried out.

Students will acquire the basic knowledge to enable them to understand the principles, scope and limitations of laboratory methods in current use, and their relevance to biomedical science.

This module is only suitable for students who do not have a first degree in a biomedical sciences subject.

Understanding Research and Critical Appraisal: Biomedicine

  • This module aims to provide students with the transferable skills used in a career in biomedicine and the skills to improve subsequent job applications in biomedicine.
  • It will provide students with an increased understanding of the scientific method and concepts of experimental design applied to Biomedicine.
  • It will provide the students  with critical thinking skills and the ability to evaluate data presented in scientific talks and papers.
  • By attending a day-long symposium, presenting a poster, and giving an oral presentation at the symposium, the students will become familiar with scientific communication and discussion.
  • The students will have acquired new transferable skills that will be used in biomedical jobs, and improved their existing transferable skills set.
  • The module will enable students to have an increased understanding of the scientific approach to addressing problems in biomedicine.
  • Student will understand what is required in applications for biomedical related jobs and PhDs.
  • Students will be able to read a paper or attend a presentation and be able to critically evaluate the data and conclusions.
  • Students will become familiar with common modes of scientific communication, be able to give presentations about their work, discuss their research on a poster, and talk to other people about their research.

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