The Clinical Epidemiology Group is investigating potentially remediable aetiologic and prognostic factors for specific coronary disease phenotypes. We undertake this research via a number of projects:
CArdiovascular disease research LInking Bespoke studies and Electronic Records (CALIBER)
In this consortium, funded by the Wellcome Trust, we are exploiting large scale resources such as the national register of acute coronary syndromes, linked to the primary care record, and investigator led ("bespoke") studies, which collect DNA and other exposures, (e.g. Whitehall II). We have linked some 25,000 differentiated acute coronary syndrome endpoints from MINAP (Myocardial Ischaemia National Audit Project) to the primary care record in GPRD (General Practice Research Database).
More information: www.caliberresearch.org
Primary contact: Spiros Denaxas
Clinical Cohorts in Coronary disease Collaboration (4C)
This project is funded by our NIHR programme grant and involves phenotyping and genotyping people with suspected and confirmed stable coronary disease, with follow up for coronary endpoints. This study will allow a range of translational research questions to be addressed under different study designs appropriate to studying the causes of disease onset (case-control), disease progression (cohort) and pharmacogenetic effects.
Primary contact: Natalie Fitzpatrick
PROGnosis RESearch Strategy initiative (PROGRESS)
This is an MRC funded international, interdisciplinary collaboration developing understanding in research into quality of care outcomes, prognostic factors, risk prediction models and predictors of differential treatment response.
More information: www.progress-partnership.org
Primary contact: Alireza Moayyeri
Farr Institute of Health Informatics Research, London
Farr London is one of four E-Health Informatics Research Centres funded by the MRC in partnership with Arthritis Research UK, the British Heart Foundation, Cancer Research UK, the Economic and Social Research Council, the Engineering and Physical Science Research Council, The National Institute of Health Research, the National Institute for Social Care and Health Research (Welsh Assembly Government), the Chief Scientist Office (Scottish Government Health Directorates) and the Wellcome Trust.
Primary contact: Denise Beales