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CDB Seminars __________________________ Following the Summer Break the Series returns in September.
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Current CDB seminars
All welcome to attend. Seminars take place on Thursdays from 1-2pm. Please contact the seminar host if you wish to meet the speaker. To receive details of forthcoming CDB Seminars, you can subscribe directly to the biosciences mailing list.
See also:
Spring Term 2013 |
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Wednesday 26 June, 12.30-4.40pm Gavin de Beer Lecture Theatre, Ground Floor, Anatomy Building Hosts: Steve Hunt and Michael Duchen
12.30pm Ricardo Laranjeiro: "A novel cyclin-dependent kinase inhibitor (p20) controls circadian cell cycle timing" 1.00pm Mark Hajjawi: “Nucleotides as regulators of skeletal function” 1.30pm Keri Tochiki: “Are histone modifications setting up inflammatory pain states?” 2.00pm Gordon Walsh: "Model construction and
parameter determination in eukaryotic phosphoinositide metabolism" 2.40pm Mason Yeh: “The role of slit-robo signalling in the generation of cortical pyramidal neurons” 3.10pm Beverley Bright: “The importance of connexins in tissue repair” 3.40pm Eleanna Stamatakou: “Activity-dependent spine morphogenesis: a role for the actin-capping protein Eps8”
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Thursday 27 June at 1pm Prof Richard Zigmond, Case Western Reserve University Title: A new phenotype for the well-studied slow Wallerian degeneration mouse: A critical role in the conditioning lesion response for inflammation near axotomized neurons Host: Prof Patrick Anderson Venue: Anatomy Room 106 |
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First Year CDB PhD Students:
Mini Symposium Monday 1 July, 1.00-2.00pm Tuesday 2 July, 1.00-3.00pm |
Autumn Term 2013 |
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October (postponed from June 6th) Prof Mathias Ziegler, University of Bergen Title: TBC Host: Professors Michael Duchen and Sandip Patel Venue: Anatomy G04 Gavin de Beer LT |
PAST SEMINARS: SpringTerm 2012 |
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Wednesday 12 June, 13.00-14.00 Dr Nicoletta Plotegher, University of Pavia Title: Unravelling the mechanisms of alpha-synuclein aggregation and toxicity Host: Prof Michael Duchen Venue: Otto Schlid LT (a.k.a The Pharmacology LT) |
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Thursday 30 May at 1pm Prof Hiroshi Kiyama, Nagoya University Title: Collapse of homeostasis by prolonged stress - A model for Chronic Fatigue Syndrome and Fibromyalgia Host: Prof Gennadij Raivich Venue: JZ Young Lecture Theatre |
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Thursday 23 May at 1pm Professor Enrique Amaya, University of Manchester Title: Unlocking the secrets of scarless wound healing and appendage regeneration Host: Prof Sandip Patel Venue: Anatomy G04 Gavin de Beer LT |
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Thursday 16 May at 1pm Prof Corinne Houart, King's College London Title: Temporal control of signalling centres in regulation of forebrain size and complexity Host: Prof David Whitmore Venue: Medical Sciences 131 A V Hill LT |
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Thursday 9 May at 1pm Prof Mitch Glickstein, UCL CDB Title: The Curious History of the Corpus Callosum, its Role in Memory Storage, and the Localization of Function in the Cerebral Cortex Host: Prof David Whitmore Venue: Medawar G02 Watson LT |
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Thursday 2 May at 1pm Dr Christopher Bell, UCL Cancer Institute Title: Insights into Human Disease through integrated Epigenomic & Comparative Analysis Host: Dr Sandrine Geranton Venue: JZ Young Lecture Theatre |
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Thursday 25 April at 1pm Prof Andy Oates, UCL CDB Title: On the origin of the kinematic gene expression waves in the zebrafish segmentation clock Host: Prof David Whitmore Venue: Anatomy G04 Gavin de Beer LT |
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Wednesday 27 March at 1pm Professor Geoffrey Raisman, UCL Title: Glaucoma: nerve fibres are dependent on glial cells, but they have to manage a difficult dual role in the optic nerve Host: Prof Steve Hunt Venue: JZ Young LT |
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Thursday 14 March at 1pm Professor James Hall, UC Irvine Title: Aquaporin Zero: Mechanisms of Regulation and Roles in the Optical Lens Host: Prof David Becker Venue: Anatomy G04 Gavin de Beer LT |
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Thursday 21 February at 1pm Dr Helen Morrison, Leibiniz-Institut fur Aktersforschung Title: What a tumour suppressor can do for your Brain Host: Prof Rhona Mirsky Venue: Anatomy G04 Gavin de Beer LT |
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Friday 22 February at 1pm Dr Ralf Schnabel, Technische Universitat Braunschweig Title: Phainothea: Creation of form by cell focussing in the C. elegans embryo Host: Dr Richard Poole Venue: Anatomy G04 Gavin de Beer LT |
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Thursday 24 January at 1pm Dr Thomas Wills, UCL CDB Title: The development of spatially-tuned neural activity in the Hippocampal Formation Host: Prof David Whitmore Venue: Anatomy G04 Gavin de Beer LT |
PAST SEMINARS: AutumnTerm 2012 |
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Thursday 20 December at 1pm Prof Bennett Novitch, UCLA Title: Molecular Mechanisms Regulating Neural Progenitor Fate and Differentiation Host: Dr Stephen Price Venue: Anatomy G04 Gavin de Beer LT |
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Thursday 13 December at 1pm Dr Jason Rihel, UCL CDB Title: Sleeping with the Zebrafishes Host: Prof David Whitmore Venue: Anatomy G04 Gavin de Beer LT |
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Friday 7 December at 1pm Dr Gonzalo de Polavieja, Cajal Institute Title: Decision-making in animal groups Host: Prof Steve Wilson Venue: JZ Young Lecture Theatre |
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Thursday 6 December at 5pm Prof Jean Claude Martinou, Universite de Geneve Title: Mitochondria: from pyruvate import to RNA processing Host: Prof Michael Duchen Venue: Anatomy G04 Gavin de Beer LT |
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Thursday 6 December at 1pm Dr Claudio Alonso, University of Sussex Title:The molecular regulation of Hox genes during neural development Host: Prof Claudio Stern Venue: Anatomy G04 Gavin de Beer LT |
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Wednesday 5 December at 1.30pm CDB PhD/Postdoc Seminar Series Room 106 1.30-2.30
(1) Andrew Beale (Whitmore group): Clocks in a cave: circadian biology of the Mexican blind cavefish
(2) Elena Scarpa (Mayor group): What is the difference between epithelial and mesenchymal cell junctions: understanding the molecular basis of contact inhibition of locomotion and epithelial-mesenchymal transition |
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Thursday 29 November at 1pm Dr Arantza Barrios, UCL CDB Title: Should I stay or Should I go? Appetitive behavioural decision-making in the C. elegans male Host: Prof David Whitmore Venue: Anatomy G04 Gavin de Beer LT |
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Thursday 22 November at 1pm Dr Greg Fitzharris, UCL CDB Title: Segregating chromosomes during early mammalian development Host: Prof David Whitmore Venue: Anatomy G04 Gavin de Beer LT |
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Wednesday 21 November at 1.30pm CDB PhD/Postdoc Seminar Series Room 106 1.30-2.30
(1) Introduction (2) Richard Poole (Poole group): Symmetry and asymmetry during early neural specification in C. elegans |
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Thursday 15 November at 1pm Dr Freek Van Eeden, University of Sheffield Title: Towards a zebrafish model for von Hippel Lindau disease and hypoxic signaling Host: Prof Steve Wilson Venue: Room 106, Anatomy Building |
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Thursday 8 November at 1pm Dr Sandrine Geranton, UCL CDB Title: Are epigenetic mechanisms good targets for the treatment of pain states Host: Prof David Whitmore Venue: Medical Sciences 131 A V Hill LT |
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Thursday 1 November at 1pm
1.00pm Lucy Carty: The
role of autophagy in peripheral nerve injury
Host: Prof Steve Hunt |
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Thursday 25 October at 1pm Dr Chris Barnes, UCL CDB |
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Thursday 11 October at 1pm Dr Alpha Yap, University of Queensland Title: Dynamics of cadherin-actin cooperation at cell-cell junctions Host: Prof Roberto Mayor Venue: Room 106, Anatomy Building |
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Thursday 13 September at 1pm Dr Songhai Shi, Memorial Sloane-Kettering Cancer Center Title: Neocortex development: from neurogenesis to microcircuit assembly Host: Nicoletta Tekki-Kessaris Venue: Anatomy G04 Gavin de Beer LT |
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Monday 1 October at 4pm 4.00pm Anai Gonzalez Cordero: “Retinal repair using ES cell-derived photoreceptor precursors” (Professor Robin Ali’s lab) 4.25pm Katharina Seiferth: “Wnt signaling in the regulation of spine morphogenesis” (Professor Patricia Salinas’s lab) 4.50pm Andrew Beale: “Clocks in a cave: circadian rhythms in the Mexican blind cavefish, Astyanax mexicanus” (Professor David Whitmore’s lab) 5.15pm Sophie Pryor: “PCP signalling and spinal
neurulation” (Professor Andrew Copp’s lab) |
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Thursday 4 October at 1pm Prof Herman Spaink, Universiteit Leiden Title: High throughput screening for disease in zebrafish Host: Prof David Whitmore Venue: Anatomy G04 Gavin De Beer LT |
PAST SEMINARS: Summer Term 2012 |
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Thursday 21 June at 12pm Dr James McCutcheon, University of Illinois at Chicago Title: Hedonic and Metabolic influences on dopamine signaling Host: Prof Steve Hunt Venue: Gavin De Beer LT |
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CDB PhD Student Symposium Thursday 21 June, 1.00-4.10pm Room 106, 1st Floor, Anatomy Building |
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First Year CDB PhD Students: Mini Symposium 9.30am Stephanie Sundier: "Role of Mitochondrial Calcium Uptake in
Cardiac Injury Following Ischemia and Reperfusion" |
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CDB PhD Student Symposium
1.00pm Manuela Melchionda: "The Role of Complement C9 in Neural Crest
Induction" |
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Tuesday 19 June at 11.00am Dr Enrique Jaimovich, CEMC Title: Regulation of gene expression in skeletal muscle: from frequency-dependent plasticity to altered pathways in muscular dystrophy Host: Jose Vicencio Bustamante Venue: G46 HO Schild Pharmacology LT |
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Thursday 31st May at 1pm Prof Michael Ryan, La Trobe University Title: Mitochondrial biogenesis: building the generator and breaking up the factory Host: Laura Osellame Venue: Medical Sciences G46 H O Schild Pharmacology LT |
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Wednesday 30th May at 4pm Dr Dies Meijer, Erasmus University, Rotterdam Title: Role of Lgi proteins in nervous system development and function Host: Prof David Whitmore Venue: Chadwick B05 Lecture Theatre (Access from North Entrance/staircase, Chadwick Building, Main Quad) |
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Thursday 24 May at 1pm Prof Dimitri Kullman, UCL Institute of Neurology Title: Potassium channel and optogenetic therapy for experimental epilepsy Host: Prof Patricia Salinas Venue: JZ Young Lecture Theatre |
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Thursday 17 May at 1pm Prof Ashley Bruce, University of Toronto Title: Maternal control of early zebrafish morphogenesis Host: Dr Masa Tada Venue: Anatomy G04 Gavin de Beer LT |
PAST SEMINARS: Spring Term 2012 |
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Wednesday 4 April at 4pm The JZ Young Memorial Lecture Professor Russell Foster, University of Oxford Title: Sensing Light and Time Using Non-Visual Novel Photoreceptors Host: Prof David Whitmore Venue: JZ Young Lecture Theatre |
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Thursday March 29 at 1pm Prof Rosario Rizzuto, Università degli Studi di Padova Title: The mitochondrial calcium uniporter: molecular identification and physiological investigation Host: Dr Gyorgy Szabadkai Venue: JZ Young Lecture Theatre |
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Thursday 22 March at 1pm Dr Miguel Maroto, University of Dundee Title: The vertebrate segmentation clock Host: Prof David Whitmore Venue: Chadwick B05 Lecture Theatre (Access from North Entrance/staircase, Chadwick Building, Main Quad) |
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Thursday 8 March at 1pm Professor Ralf Stumm, Jena University Title: A scavenger herding the flock - how the atypical chemokine receptor CXCR7 guides neuronal migration Host: Prof John Parnavelas Venue: JZ Young Lecture Theatre |
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Thursday 1 March at 1pm Professor James Fawcett, Cambridge University Centre for Brain Repair Title: Plasticity and recovery of function in the CNS: the unexpected story of the perineuronal net Host: Prof Patricia Salinas Venue: JZ Young Lecture Theatre |
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Friday 17 February at 1pm Prof Oscar Marin, Universidad Miguel Hernández Title: Excitatory and inhibitory cell assemblies in the cerebral cortex Host: Prof Patricia Salinas Venue: Chadwick B05 Lecture Theatre (Access from North Entrance/staircase, Chadwick Building, Main Quad) |
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Thursday 16 February at 1pm Dr Beatriz Rico, Universidad Miguel Hernández Title: Neural circuit wiring: from axon development to synapse formation Host: Prof Patricia Salinas Venue: Gavin De Beer Lecture Theatre |
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Thursday 2 February at 1pm Dr Derek Stemple, Wellcome Trust Sanger Institute Title: Genetic dissection of Zebrafish Sarcomere Assembly Host: Prof David Whitmore Venue: Gavin De Beer Lecture Theatre |
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Thursday 19 January at 1pm Dr Lazaro Centanin, Heidelberg University Title: Neural Stem Cells in a Constantly Growing Niche Host: Professor Steve Wilson and the Centre for Stem Cells and Regenerative Medicine Venue: Gavin De Beer Lecture Theatre |
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Thursday 12 January at 1pm Dr Andrew Oates, Max Planck Institute Title: Patterning an embryo with oscillations Host: Professor David Whitmore Venue: JZ Young Lecture Theatre |
PAST SEMINARS: Autumn Term 2011 |
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First Year CDB PhD Students: Mini Symposium Thursday 15 December 3.45pm Isidoro Cobo: The role of C3b in Neural Crest induction 4.00pm Douglas Lopes: Wnt signaling mediated synaptic maintenance modulates learning and memory Host: Yoshiyuki Yamamoto Venue: Room 106, 1st Floor, Anatomy Building |
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Thursday 24 November at 1pm Host: Prof. Steve Hunt |
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Thursday 10 November at 1pm Host: Dr Sandip Patel Venue: Gavin De Beer Lecture Theatre |
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Thursday 20 October at 1pm Host: Prof David Whitmore |
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Thursday 6 October at 1pm Dr Elaine Dzierzak, Erasmus MC Title: Endothelial origins of hematopoietic stem cells Host: Prof David Whitmore Venue: JZ Young Lecture Theatre |
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Thursday 6th October 5.30pm Dr Peter Burgess, Proff John Cooper & Margaret Cooper, Elaine Shervil BAZH: British Association Zebrafish Husbandry Title: The 3 Ds of Disease, Description, Detection, Diagnosis Host: Carole Wilson Venue: Pearson Lecture Theatre |
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Friday 30 September at 1pm Title: Hard to kill: how the zebrafish lateral line system copes with insult and injury Host: Dr Rodrigo Young Venue: Room 106, Anatomy Building |
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Thursday 29 September at 1pm Title: Pro-survival and pro-death molecular events downstream of NMDA receptor activity Host: Prof Patricia Salinas Venue: Gavin De Beer Lecture Theatre |
PAST SEMINARS: Summer term 2011 |
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Thursday 18 August, 1.00-2.30pm, Room 106, 1st Floor, Anatomy
Building CDB PhD Student Symposium Host: Steve Hunt 1.00pm Julija Krupic: "Periodic bands are the building blocks of locational firing in the Parahippocampal Formation" 1.30pm Sittipon Intarapat: "Isolation and Characterization of Chick Embryonic Primordial Germ Cells" 2.00pm Marc Astick: "FGF and Cadherins in Cranial Nucleogenesis" |
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Thursday July 14 at 4pm Prof Ralf Stanewsky, Queen Mary University of London Title: Keeping the Drosophilia circadian clock in synchrony with environmental light:dark and temperature cycles Host: Prof David Whitmore Venue: JZ Young LT, Anatomy Building |
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Tuesday July 12 at 1pm Professor Patrick Tam, University of Sydney Title: Genetic and signaling activity influencing the morphogenesis and differentiation of the gut endoderm Host: Prof Claudio Stern Venue: Gavin de Beer LT |
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Monday July 11 at 1pm Prof Joshua Gamse, Vanderbilt Kennedy Center Title: Big Time Lov-ER: Building an asymmetric brain in the Zebrafish embryo Host: Prof Steve Wilson Venue: Room 106, Anatomy Building |
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First Year CDB PhD Students: Mini Symposium Wednesday 6 July, 1.00-2.55pm Room 106, 1st Floor, Anatomy Building Host: Yoshiyuki Yamamoto 1.00pm Keri Tochiki: "Epigenetic regulation of pain processing" 1.15pm Jessica Sutcliffe: "Chronic wounds and fibrosis" 1.30pm Daniel Gilmartin: "Targeting healing of chronic wounds" 1.45pm Beverley Bright: "Ischemia reperfusion and cell injury in pressure ulcers" 2.00pm interval 2.10pm Mark Hajjawi: "Purinergic signalling and the regulation of bone cell function" 2.25pm Mason Yeh: "The role of Robo1 in cortical development" 2.40pm Gordon Walsh: "The construction and parametrisation of a kinetic model of phosphoinositide metabolism" |
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Thursday 30 June, 1.00-4.00pm, Room 106, 1st Floor, Anatomy
Building CDB PhD Student Symposium Hosts: Steve Hunt and Michael Duchen 1.00pm Ruth Weir: "The NK1 receptor knock-out mouse as a model for ADHD" 1.30pm Caroline Dalton: "Dynamics of Mitochondrial Distribution and ATP Levels During Oocyte Maturation" 2.00pm Miia Bovellan: "Two actin nucleators are necessary to form the submembranous actin cortex" 2.30pm Kenzo Ivanovitch: "Characterization of the cellular behaviors underlying optic vesicles formation in Zebrafish" 3.00pm Sanusi Bello ''The Role of Cadherins and Catenins in the spinal motor neurons migration and segregation'' 3.30pm Stephen Burton: "The role of the NMDA receptor NR1 subunit in the spatial coding of dentate cells" |
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Monday June 27 4pm Professor Gail Martin, University of California San Francisco Title: FGF Signalling in vertebrate organogenesis: how sprouty genes help get it right Host: Prof John Carroll Venue: AV Hill Lecture Theatre |
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Thursday 23 June, 1.00-3.40pm, Room 106, 1st Floor, Anatomy
Building CDB PhD Student Symposium Hosts: David Whitmore, Chris Dean and Michael Duchen 1.00pm Michelle Key: "Acidosis, a fundamental regulator of bone cell function" 1.30pm Jessal Patel: "Exploring the actions of hypothermia and PPARs on the differentiation and function of bone cells" 2.00pm Matthew Stower: "Unravelling Neural Induction" 2.30pm interval 2.40pm Rob Hooper: "Two-pore channels; the molecular basis for calcium release by NAADP" 3.10pm Catherine Cox: "The Circadian Clock and The Cell Cycle" |
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Wednesday June 22 10.00am Dr Barry Kaplan, National Institutes of Health, Bethesda, MD Title: Subcellular Compartmentation of Neuronal Protein Synthesis: New Insights into the Biology of the Neuron Host: Prof Steve Hunt Venue: Room 249, Anatomy Building |
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Thursday June 2 at 1pm Dr Melina Schuh, Cell Biology Division, MRC Laboratory of Molecular Biology, Cambridge Title: Oocyte + Actin: Old Love – New Affairs Host: Prof John Carroll Venue: JZ Young Lecture Theatre, Anatomy Building |
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Thursday May 26 at 1pm Prof David Strutt, MRC Centre for Developmental and Biomedical Genetics, University of Sheffield Title: Local coordination of planar polarity through cell-cell interactions Host: Dr Masa Tada Venue: A V Hill Lecture Theatre, Medical Sciences Building |
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Thursday May 19 at 1pm Host: Prof Claudio Stern Venue: A V Hill Lecture Theatre, Medical Sciences Building |
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Wednesday May 18 at 1pm Dr Jonathan Chubb, College of Life Sciences, University of Dundee Title: Heterogeneity
and Stability of Transcriptional States Host: Prof Claudio Stern Room 106, Anatomy Building |
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Tuesday May 17 at 4pm Professor Andrew Miller, The Hong Kong University of Science and Technology Title: Complementary Luminescent and Fluorescent Imaging Techniques to Visualize Nuclear and Cytoplasmic Ca2+signaling during in vivo Differentiation of Zebrafish Slow Muscle Cells under Normal and Dystrophic Conditions Host: Professor David Whitmore Venue: The JZ Young Lecture Theatre |
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Friday May 6 Young Embryologist Network (YEN) Meeting 2011 Organised by PhD students from the UCL Research Department of Cell and Developmental Biology Full details, programme and venue on the YEN website |
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Thursday May 5 at 1pm Prof Christopher Wylie, William Schubert Professor and Director, Division of Developmental Biology, Cincinnati Children's Hospital Medical Center, USA Title: The developmental biology toolbox in basic and translational studies Host: Prof Claudio Stern Venue: A V Hill Lecture Theatre, Medical Sciences Building |
PAST SEMINARS: Spring term 2011 |
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Thursday January 20 at 1pm Prof Georgy Koentges, Laboratory of Genomic Systems Analysis, University of Warwick Title: Deconstructing vertebrate dermal bone growth and its evolutionary history Host: Prof Susan Evans Venue: Gavin de Beer Lecture Theatre, Anatomy Building |
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Thursday January 27 at 1pm Prof James Briscoe, MRC National Institute for Medical Research Title: The gene regulatory logic for reading the Sonic Hedgehog gradient in the vertebrate neural tube Host: Prof Lewis Wolpert Venue: Gavin de Beer Lecture Theatre, Anatomy Building |
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Thursday February 3 at 4pm Prof Luca Scorrano, School of Medicine, Université de Genève Switzerland Title: Size matters! Mitochondrial elongation and the control of autophagy Host: Dr Gyorgy Szabadkai Venue: A V Hill Lecture Theatre, Medical Sciences Building |
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Thursday February 10 at 1pm CDB PhD Student Seminars Dr Daniel Wilton Title: Numbing the Schwann cell and Caroline Dalton Title: Changes in mitochondrial distribution and ATP levels during oocyte maturation Host: Prof Steve Hunt Venue: Gavin de Beer Lecture Theatre, Anatomy Building |
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Thursday March 3 at 1pm Dr David Parkinson, Peninsula College of Medicine and Dentistry, Universities of Exeter and Plymouth Title: Controlling Schwann cell Myelination in Development and Disease Host: Prof Rhona Mirsky Venue: Gavin de Beer Lecture Theatre, Anatomy Building |
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Thursday March 10 at 1pm Dr Grant Wheeler, School of Biological Sciences, University of East Anglia Title: Small molecule screens in Xenopus identify inhibitors of pigment cell development, neural crest development and melanoma growth Hosts: Dr Sandip Patel and Dr Les Dale Venue: Gavin de Beer Lecture Theatre, Anatomy Building |
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Friday March 18 at 4pm J Z Young Memorial Lecture 2011 See Special Seminars |
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Thursday March 24 at 1pm Dr Joseph Kittler, UCL Research Department of Neuroscience, Physiology & Pharmacology Title: Rapid synaptic delivery and removal of GABAA receptors and the tuning of inhibitory transmission Hosts: Prof David Whitmore Venue: Gavin de Beer Lecture Theatre, Anatomy Building |
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CDB Special Seminar Hosted by the Young Embryologist Network Thursday 24th March from 4pm to 6pm Dr Florencia Cavodeassi (Wilson Group, CDB, UCL). Title: "From eye field to optic cup: imaging eye morphogenesis in the zebrafish" & Professor Scott Fraser, Anna L. Rosen Professor of Biology & Engineering and Applied Science, Beckman Institute, Caltech. Title: "New tools for imaging the motions and fates of embryonic cells." Refreshments will be served afterwards Venue: AV Hill Lecture Theatre |
PAST SEMINARS: Autumn term 2010 |
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Thursday June 9 at 1pm Prof Stephan Neuhauss, Institute of Molecular Life Sciences, University of Zurich Title: Earning Its Strips: Elucidating Retinal Function with Visual Behaviour in the Zebrafish Host: Prof Steve Wilson Venue: A V Hill Lecture Theatre, Medical Sciences Building |
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Monday October 11 at 1pm See: SPECIAL SEMINARS |
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Thursday October 14 at 1pm Dr Nobuaki Kudo Institute of Reproductive and Developmental Biology, Imperial College London Title: Maintenance of Meiotic Prophase in Mouse Oocytes Host: Prof John Carroll Venue: A V Hill Lecture Theatre, Medical Sciences Building Abstract: Since aneuploid embryos, which result in spontaneous abortion or congenital diseases, are mostly originated from aneuploid eggs or sperm, meiotic chromosome mis-segregation is the major cause of aneuploidy. It has been known that chromosome segregation during meiosis I in human oocytes is highly error-prone, however the reason is unknown. Bi-orientation of chromosomes on the spindle is dependent on cohesion between sister chromatids which is mediated by the cohesin complex. Cohesin is loaded onto chromosomes before DNA replication by the activity of an evolutionarily conserved chromosomal protein called Nipbl/Scc2. Mammalian oocytes undergo DNA replication and form crossovers before birth, which is followed by an arrest at a late stage of meiotic prophase for an extended period of time. Bi-orientation of chromosomes at meiosis I, which is dependent on chiasmata and cohesion, happens after puberty. Achiasmatic chromosomes that have lost cohesion precociously are the major type of chromosome mis-segregation (known as nondisjunction) in meiosis I. Therefore, the stable maintenance of cohesion during the protracted meiotic prophase arrest is probably essential for faithful chromosome segregation. However, whether and how cohesin is maintained during this arrest is unknown. Our approach to address the above question is to investigate oocytes which has undergone S-phase and crossing-over with active Nipbl but whose Nipbl activity has been specifically eliminated during the late stage of meiotic prophase arrest. We obtain such oocytes by breeding mice with a conditional Nipbl allele and the Zp3-cre transgene that deletes floxed loci during growing stage of oocytes. We will report our unpublished observations on Nipbl-deleted oocytes. |
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Thursday October 21 at 1pm Abstract: The ARX (Aristaless-related homeobox) gene is implicated in a wide spectrum of disorders characterised by mental retardation with or without epilepsy. In the most severe cases, it is associated to cerebral malformations such as lissencephaly. This gene encodes a homeobox transcription factor which is primarily expressed in interneurons in embryonic and adult brain. Several studies using mutant mice or RNA interference approaches have recently shown the involvement of ARX in different processes such as proliferation of neuroblasts, neuronal migration and neuronal differentiation. In order to better understand the role of ARX in corticogenesis, we used the ChIP-on-Chip (chromatin immunoprecipitation on DNA microarrays) technique to identify some of ARX targets. The identified genes confirm that ARX is involved in different developmental processes such as cell proliferation and migration but also myelinisation, axonal elongation and synaptogenesis. |
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Thursday November 4 at 1pm Prof Amanda Fisher Director, MRC Clinical Sciences Centre Title: Resetting the lineage clock - how does reprogramming work? Host: Prof Claudio Stern Venue: A V Hill Lecture Theatre, Medical Sciences Building |
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Tuesday November 9 at 1pm See SPECIAL SEMINARS |
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Thursday November 11 at 1pm Prof Pierre-Marie Lledo Head of Perception and Memory laboratory, Institut Pasteur, Paris Title: Is Adult Neurogenesis Essential for Olfaction? Host: Prof Bill Richardson Venue: A V Hill Lecture Theatre, Medical Sciences Building |
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Thursday December 2 at 1pm Dr Antonella Riccio MRC Laboratory for Molecular Cell Biology / UCL Research Department of Neuroscience, Physiology and Pharmacology Title: A novel epigenetic mechanism in neurons Host: Prof Patricia Salinas Venue: A V Hill Lecture Theatre, Medical Sciences Building |
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Thursday December 9 at 1pm Prof Nils Brose CANCELLED DUE TO ADVERSE WEATHER CONDITIONS which prevented Prof Brose from travelling to the UK |
Page last modified on 26 jun 13 14:20 by Edward D Whitfield
