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CDB Seminars
All welcome

Thursday 30 May at 1pm
Prof Hiroshi Kiyama, Nagoya University
Title: Collapse of homeostasis by prolonged stress - A model for Chronic Fatigue Syndrome and Fibromyalgia
Host: Prof David Whitmore
Venue: JZ Young Lecture Theatre

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Thursday 27 June at 1pm
Prof Richard Zigmond, Case Western Reserve University
Title: A new phenotype for the well-studied slow Wallerian degeneration mouse: A critical role in the conditioning lesion response for inflammation near axotomized neurons
Host: Prof David Whitmore
Venue: Anatomy G04 Gavin de Beer LT

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Prof Sandip Patel

 

Professor of Cell Signalling

patel.s@ucl.ac.uk

Telephone:
Office: 020 7679 4437
(Int: 34437)

Research

Intracellular Calcium Mobilising Messengers
Increases in cytosolic calcium levels are pivotal for the regulation of a wide range of cellular processes. Paradoxically, calcium can activate opposing cellular fates and understanding how calcium exerts such exquisite specificity is a subject of intense study. Different extracellular stimuli may utilise distinct combinations of intracellular calcium mobilising messengers to generate specific calcium “signatures”. These temporally and spatially complex calcium signals can then be decoded by the cell to achieve a given cellular response.

Areas of interest


Nicotinic Acid Adenine Dinucleotide Phosphate (NAADP) - A Novel Intracellular Calcium Mobilising Messenger
We are investigating the role of the newly described calcium mobilising agent, nicotinic acid adenine dinucleotide phosphate (NAADP), in the control of calcium dynamics in several systems including sea urchin eggs, pancreatic acinar cells and neurons. Projects are aimed at characterising the spatial aspects of NAADP-induced calcium increases using digital imaging techniques, measuring cellular NAADP levels in response to physiological stimulation, defining the enzymatic route for NAADP synthesis and metabolism and identifying the putative NAADP receptor and enzymatic machinery at the molecular level.

Publications

View all of Prof Patel's publications via the UCL Research Publications System

Page last modified on 16 jan 12 14:01 by Ed Whitfield