All Seminars are held in the Gavin De Beer Lecture Theatre, Anatomy Building, Thursday 1-2pm
29 Jan 15: Daniel Gilmartin (Becker’s lab) Development of a wound healing scaffold that targets connexins / Tom Briston (Duchen lab) Identification and development of novel inhibitors of mitochondrial permeability transition
12 Feb: Ana Faro (Wilson lab)/ Irene Marta Almeida (Stern lab)
26 Feb: Prof Hannes E. Buelow, Albert Einstein College of Medicine, NY.
5 March: András Szabó (Mayor lab) / Pedro Pereira (Henriques’ lab)
12 March: Jose Gomez (Jessen lab)/Sara Maffioletti (Tedesco lab)
26 March: Lizzie Yates (Patel lab) / Melissa Barber (Parnavelas lab)
9 April: Zeki lab –TBC/ Francis Carpenter (Caswell Barry lab)
23 April: Florent Peglion (Nate Guring lab)/Michele Sammut (Barrios lab, now in Poole lab)
Prof Sandip Patel
Professor of Cell Signalling
Intracellular Calcium Mobilising
Increases in cytosolic calcium levels are pivotal for the regulation of a wide range of cellular processes. Paradoxically, calcium can activate opposing cellular fates and understanding how calcium exerts such exquisite specificity is a subject of intense study. Different extracellular stimuli may utilise distinct combinations of intracellular calcium mobilising messengers to generate specific calcium “signatures”. These temporally and spatially complex calcium signals can then be decoded by the cell to achieve a given cellular response.
Areas of interest
Nicotinic Acid Adenine Dinucleotide Phosphate (NAADP) - A Novel Intracellular Calcium Mobilising Messenger
We are investigating the role of the newly described calcium mobilising agent, nicotinic acid adenine dinucleotide phosphate (NAADP), in the control of calcium dynamics in several systems including sea urchin eggs, pancreatic acinar cells and neurons. Projects are aimed at characterising the spatial aspects of NAADP-induced calcium increases using digital imaging techniques, measuring cellular NAADP levels in response to physiological stimulation, defining the enzymatic route for NAADP synthesis and metabolism and identifying the putative NAADP receptor and enzymatic machinery at the molecular level.
View all of Prof Patel's publications via the UCL Research
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Page last modified on 07 jun 13 10:12 by Edward D Whitfield