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CDB Seminars
All welcome

Thursday 24 May at 1pm
Prof Dimitri Kullman, UCL Institute of Neurology
Title: Potassium channel and optogenetic therapy for experimental epilepsy
Host: Prof Patricia Salinas
Venue: JZ Young Lecture Theatre

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Thursday 31st May at 1pm
Prof Michael Ryan, La Trobe University
Title: Mitochondrial biogenesis: building the generator and breaking up the factory
Host: Prof Michael Duchen
Venue: Medical Sciences G46 H O Schild Pharmacology LT

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Prof John Parnavelas

Neuronal migration in the forebrain

Lab Members | Contact Us | Publications

Lab

Research Interests

Work in our laboratory has, for many years, focused on the origin and migration of the neurons that make up the mammalian cerebral cortex. Two broad classes of neurons have been identified in the cortex: the excitatory pyramidal neurons and the inhibitory interneurons. Pyramidal cells are derived from the neuroepithelium of the cortical ventricular zone, whereas interneurons arise in the ganglionic eminence of the ventral telencephalon. Earlier studies identified the origin of interneurons and described their tortuous migratory routes into the developing cortex. Our current studies focus on the cell and molecular mechanisms that underlie each step of their journey.

Even though most of our efforts focus on interneuron migration in the cortex, we are also exploring the molecular mechanisms that guide the migration of Gonadotropin-releasing hormone (GnRH) neurons from their origin in the olfactory placode to the hypothalamus. The significance of our research programme lies with the opportunity to understand the mechanisms involved in neuronal migration in the brain and to shed light in the aetiologies of some of the migration disorders in humans.

Finally, we are exploring the role(s) of molecules involved in forebrain neuron migration (e.g., Robo receptors) in the development of the innervations of the heart.

Lab members

Prof John Parnavelas lab members

Contact

Labs B21-B25
Department of Cell and Developmental Biology
Anatomy Building
University College London
Gower Street
London, WC1E 6BT
United Kingdom

Tel: 020 7679 3289

Map of our location

Publications

  • Hernández-Miranda, LR., Cariboni, A., Faux, C., Ruhrberg, C., Cho, JH., Cloutier, J-F., Eickholt, BJ., Parnavelas, JG. and Andrews, WD. (2011) Robo1 regulates semaphorin signaling to guide the migration of cortical interneurons through the ventral forebrain. J Neurosci. (In Press).
  • Cariboni, A., Davidson, K., Rakic, S., Maggi, R., Parnavelas, JG. and Ruhrberg, C. (2011) Defective gonadotropin-releasing hormone neuron migration in mice lacking SEMA3A signalling through NRP1 and NRP2; implications for the aetiology of hyponadotropic hypogonadism. Human Mol Genet. 20: 336-344.
  • Elias, LA., Turmaine, M., Parnavelas, JG. and Kriegstein, AR. (2010) Connexin 43 mediates the tangential to radial migratory switch in ventrally derived cortical interneurons. J Neurosci. 30: 7072-7077.
  • Zacharaki, T., Sophou, S., Giannakopoulou, A., Dinopoulos, A., Antonopoulos, J., Parnavelas, JG. and Dori, I. (2010) Natural and lesion-induced apoptosis in the dorsal lateral geniculate nucleus during development. Brain Res. 1344: 62-76.
  • Hernández-Miranda, LR., Parnavelas, JG. and Chiara, F. (2010) Molecules and mechanisms involved in the generation and migration of cortical interneurons. ASN Neuro 2: e00031.
  • Friocourt, G. and Parnavelas JG. (2010) Mutations in ARX result in several defects involving GABAergic neurons. Front Cell Neurosci. 4: article 4.
  • Faux, C., Rakic, S., Andrews, W., Yanagawa, Y., Obata, K. and Parnavelas, JG. (2010) Differential gene expression in migrating cortical interneurons during mouse forebrain development. J Comp Neurol. 518: 1232-1248.
  • Prince, J.E., Cho, J.H., Dumontier, E., Andrews, W., Cutforth, T., Tessier-Lavigne, M., Parnavelas, J. and Cloutier, J-F. (2009) Robo-2 controls the segregation of a portion of basal vomeronasal sensory neuron axons to the posterior region of the accessory olfactory bulb. J Neurosci. 29: 14211-14222.
  • Thompson, H., Andrews, W., Parnavelas, JG. and Erskine L. (2009) Robo2 is required for Slit-mediated intraretinal axon guidance. Dev Biol. 335: 418-426.
  • Barber, M., Di Meglio, T., Andrews, WD., Hernández-Miranda, LR., Murakami, F., Chédotal, A. and Parnavelas, JG. (2009) The role of Robo3 in the development of cortical interneurons. Cereb Cortex 19: i22-i31.
  • Rakic, S., Yanagawa, Y., Obata, K., Faux, C., Parnavelas, JG. and Nicolic, M. (2009) Cortical interneurons require p35/Cdk5 for their migration and laminar organization. Cereb Cortex 19: 1857-1869.
  • Mellios, K., Zacharaki, T., Sophou, S., Latsari, M., Antonopoulos, J., Dinopoulos, A., Parnavelas, JG. and Dori, I. (2009) Natural and lesion-induced apoptosis in the rat striatum during development. Brain Res. 1252: 30-44.
  • Hoerder-Suabedissen, A., Wang, WZ., Lee, S., Davies, KE., Goffinet, AM., Rakic, S., Parnavelas, J., Reim, K., Nicolic, M., Paulsen, O. and Molnár, Z. (2008) Novel markers reveal subpopulations of subplate neurons in the murine cerebral cortex. Cereb Cortex 19: 1738-1750.
  • Friocourt, G., Kanatani, S., Tabata, H., Yozu, M., Takahashi, T., Antypa, M., Raguénes, O., Chelly, J., Férec, C., Nakajima, K. and Parnavelas, JG. (2008) Cell-autonomous roles of ARX in cell proliferation and neuronal migration during corticogenesis. J Neurosci.  28: 5794-5805.
  • Plachez, C., Andrews, W., Liapi, A., Knoell, B., Drescher, B., Mankoo, B., Zhe, L., Mambetisaeva, E., Annan, A., Bannister, L., Parnavelas, JG., Richards, LJ. and Sundaresan, V. (2008) Robos are required for the correct targeting of retinal ganglion cell axons in the visual pathway of the brain. Mol Cell Neurosci. 37: 719-730.
  • Liapi, A., Pritchett, J., Jones, O., Fujii, N., Parnavelas, JG. and Nadarajah, B. (2008) Stromal-derived 1 signalling regulates radial and tangential migration in the developing cerebral cortex. Dev Neurosci. 30: 117-131.
  • Andrews, W., Barber, M., Hernandez-Miranda, L.R., Xian, J., Rakic, S., Sundaresan, V., Rabbitts, T.H., Pannell, R., Rabbitts, P., Thompson, H., Erskine, L., Murakami, F. and Parnavelas, J.G. (2008) The role of Slit-Robo signaling in the generation, migration and morphological differentiation of cortical interneurons. Dev Biol. 313: 648-658.
  • Faux, CH. and Parnavelas, JG. (2007) The role of intracellular calcium and RhoA in neuronal migration. Science STKE 412: pe62.
  • Cariboni, A., Maggi, R. and Parnavelas, JG. (2007) From nose to fertility: the long migratory journey of gonadotropin-releasing hormone neurons. Trends Neurosci. 30: 638-644.
  • Cho, JH., Lepine, M., Andrews, W., Parnavelas, JG. and Cloutier, JF. (2007) Requirement for Slit-1 and Robo-2 in zonal segregation of olfactory sensory neuron axons in the main olfactory bulb. J Neurosci. 27: 9094-9104.
  • Vitalis, T., Cases, O., Passemard, S., Callebert, J. and Parnavelas, JG. (2007) Embryonic depletion of serotonin affects cortical development. Eur J Neurosci. 26: 331-344.
  • Andrews, WD., Barber, M. and Parnavelas, JG. (2007) Slit-Robo interactions during cortical development. J Anat. 211: 188-198.
  • Friocourt, G., Liu, J.S., Antypa, M., Rakic, S., Walsh, CA. and Parnavelas, JG. (2007) Both Doublecortin and Doublecortin-like kinase play a role in cortical interneuron migration. J Neurosci. 27: 3875-3883.
  • Cariboni, A., Hickok, J., Rakic, S., Andrews, W., Maggi, R., Tischkau, S. and Parnavelas, JG. (2007) Neuropilins and their ligands are important in the migration of Gonadotropin-Releasing Hormone neurons. J Neurosci. 27: 2387-2395.
  • Trinh, H-H., Reid, J., Shin, E., Liapi, A., Parnavelas, JG. and Nadarajah, B. (2006) Secreted factors from ventral telencephalon induce the differentiation of GABAergic neurons in cortical cultures. Eur J Neurosci. 24: 2967-2977.
  • Sophou, S., Dori, I., Antonopoulos, J., Parnavelas, JG. and Dinopoulos, A. (2006) Apoptosis in the rat basal forebrain during development and following lesions of connections. Eur J Neurosci. 24: 573-585.
  • Rakic, S., Davis, C., Molnar, Z., Nicolic, M. and Parnavelas, JG. (2006) Role of p35/Cdk5 in preplate splitting in the developing cerebral cortex. Cereb. Cortex 16: i35-i45.
  • Andrews W, Liapi A, Plachez C, Camurri L, Zhang J, Mori S, Murakami F, Parnavelas JG, Sundaresan V, Richards LJ. (2006) Robo1 regulates the development of major axon tracts and interneuron migration in the forebrain. Development. 133: 2243-2252.
  • Metin C, Baudoin JP, Rakic S, Parnavelas JG. (2006) Cell and molecular mechanisms involved in the migration of cortical interneurons. Eur J Neurosci. 23: 894-900. Review.
  • Friocourt G, Poirier K, Rakic S, Parnavelas JG, Chelly J. (2006) The role of ARX in cortical development. Eur J Neurosci. 23: 869-76. Review.
  • Camurri L, Mambetisaeva E, Davies D, Parnavelas J, Sundaresan V, Andrews W. (2005) Evidence for the existence of two Robo3 isoforms with divergent biochemical properties. Mol Cell Neurosci. 30: 485-493.
  • Cariboni A, Rakic S, Liapi A, Maggi R, Goffinet A, Parnavelas JG. (2005) Reelin provides an inhibitory signal in the migration of gonadotropin-releasing hormone neurons. Development. 132: 4709-4718.

Page last modified on 22 mar 11 11:16 by Glenda Young