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CDB Seminars
All welcome

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All Seminars are held in the Gavin De Beer Lecture Theatre, Anatomy Building, Thursday 1-2pm (unless otherwise stated)

All welcome.


Thursday June 2nd

Ingrid Lekk (Wilson Lab) Development of left-right asymmetries in the vertebrate brain

Claire Anderson (Stern Lab) A search for new organizers

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Thursday June 16th

Pedro Henriques (Bianco Lab NPP)

Nun McHedlishvili (Baum Lab) Microtubule cytoskeleton remodeling during mitotic entry

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Monday 20 June, 1.30-4.30pm PhD TALKS

Venue: Room 249, 2nd Floor, Medical Sciences Building, Gower Street

Final Year Students

Host: Michael Duchen

1.30pm  Kate Turner

2.00pm  Lizzie Yates

2.30pm  Alan Greig

3.00pm  Interval

First Year Students

Host: Yoshiyuki Yamamoto

3.15pm  Alex Henderson

3.30pm  Bethan Wolfenden

3.45pm  Alessandro Bossio

Final Year Student

Host: Michael Duchen

4.00pm  Chris Penny
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Thursday June 30th 

Hyung Chul (Stern Lab) Different combinations of signal inputs for specific cellular events to establish          embryonic axis

Johanna Buchler (Salinas Lab)

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Dr Sean M Davidson

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Dr Sean M Davidson

Contact

Dr Sean M Davidson
Hatter Cardiovascular Institute
University College London
67 Chenies Mews
London, WC1E 6HX

Tel: 0203 447 5732
Email: s.davidson@ucl.ac.uk

Research

I am a senior research associate at the Hatter Cardiovascular Inst, and collaborate closely with Prof. Duchen on imaging the heart using both confocal and multiphoton microscopy.

These powerful techniques allow us to visualize real-time, physiological changes in the isolated, perfused heart. I am interested in the mechanism of ischaemia and reperfusion injury such as that caused by a heart attack. Using fluorescent dyes such as TMRM it is possible to detect changes in mitochondrial membrane potential that correspond to mitochondrial damage.

Alternatively, by using transgenic mice expressing a fluorescent reporter such as GCaMP2 it is possible to measure changes in cytosolic calcium during ischaemia and reperfusion and see how they correspond to regions of damage. Although cardiac muscle cells (cardiomyocytes) make up the bulk of the heart, they are actually outnumbered by the endothelial cells which line the vasculature.

Multiphoton microscopy allows visualization of both the cardiomyocytes and endothelial cells in the native arrangement, to see how they interact. Using these and other techniques I am exploring the possibility that damage to the mitochondria in endothelial cells contributes to ischaemia and reperfusion injury.

In addition to mitochondria, I am also interested in the role of lysosomes in cardiomyocytes and their possible contribution to cell damage.

Figures

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