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CDB Seminars
All welcome

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All Seminars are held in the Gavin De Beer Lecture Theatre, Anatomy Building, Thursday 1-2pm

2 Oct 11.00am: SPECIAL SEMINAR - Dr Sudipto Roy, Institute of Molecular and Cell Biology (IMCB)
Title: Genetic control of cilia number and ciliary length
Host: Prof Steve Wilson
Venue: Room 249 Medical Sciences Building

2 Oct: Helena (Wilson lab) /Maria Maiaru (Geranton lab)

3 Oct 1pm: SPECIAL SEMINAR - Dr Matthew Dalva, Thomas Jefferson University
Title: Visualizing the dynamics of cell signaling that underlie synapse formation
Host: Prof Patricia Salinas
Venue: Gavin De Beer Lecture Theatre

16 Oct: Tom Wyatt (Charras lab) (Oates lab)

30 Oct: Harold Burgess - Title TBC (Host: Prof Steve Wilson)

31 Oct: SPECIAL SEMINAR - Sophie Jarriault (IGBMC) – Title TBC (Host: Dr Richard Poole)

6 Nov: Aude Marzo (Salinas lab)/ Maite Ogueta (Stanewsky lab)

13 Nov: (Paluch lab)/ Robert Bentham (Szabadkai lab)

27 Nov: Irene (Stern lab)/Cristina Benito(Jessen lab)

11 Dec: Marcus Ghosh (Rihel lab)/ (Chubbs lab)

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Wellcome PhD Students: Final Year Talks

Thursday 25 September

12.30-2.35pm

Room 249, 2nd Floor, Medical Sciences Building, Gower Street

12.30pm:  Scott Curran: “Annealing: the changing role of junctional actomyosin in epithelial cell packing during tissue development”

12.55pm:  Kristina Tubby: “The development of the avian auditory hindbrain”

1.20pm:  Miguel Tillo: “Signals controlling neuronal migration in the embryonic hindbrain”

1.45pm:  Alex Sinclair-Wilson: “Olig2 and regulation of neural stem cell fate”

2.10pm:  Elena Scarpa: “Cadherin-Dependent Rac1 Polarity acquired during Epithelial to Mesenchymal Transition triggers Contact inhibition of Locomotion”

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Dr Sean M Davidson

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Dr Sean M Davidson

Contact

Dr Sean M Davidson
Hatter Cardiovascular Institute
University College London
67 Chenies Mews
London, WC1E 6HX

Tel: 0203 447 5732
Email: s.davidson@ucl.ac.uk

Research

I am a senior research associate at the Hatter Cardiovascular Inst, and collaborate closely with Prof. Duchen on imaging the heart using both confocal and multiphoton microscopy.

These powerful techniques allow us to visualize real-time, physiological changes in the isolated, perfused heart. I am interested in the mechanism of ischaemia and reperfusion injury such as that caused by a heart attack. Using fluorescent dyes such as TMRM it is possible to detect changes in mitochondrial membrane potential that correspond to mitochondrial damage.

Alternatively, by using transgenic mice expressing a fluorescent reporter such as GCaMP2 it is possible to measure changes in cytosolic calcium during ischaemia and reperfusion and see how they correspond to regions of damage. Although cardiac muscle cells (cardiomyocytes) make up the bulk of the heart, they are actually outnumbered by the endothelial cells which line the vasculature.

Multiphoton microscopy allows visualization of both the cardiomyocytes and endothelial cells in the native arrangement, to see how they interact. Using these and other techniques I am exploring the possibility that damage to the mitochondria in endothelial cells contributes to ischaemia and reperfusion injury.

In addition to mitochondria, I am also interested in the role of lysosomes in cardiomyocytes and their possible contribution to cell damage.

Figures

Page last modified on 11 jul 12 11:52 by Edward D Whitfield