Issue 3 - October 2008
Editor - Ruth Lovering
We are pleased to announce that
our new and improved website is now online. The updated site incorporates several new
features, including; a link to the Search CV
gene list, which enables scientists to search the BHF-UCL
Cardiovascular gene list; and a feedback form
for scientists to comment on any aspect of GO or to subscribe to this
In August Ruth attended the 7th Human Proteome Organisation World Congress
in Amsterdam. Ruth made contact with several senior
scientists who have agreed to help with the annotation of genes in the BHF-UCL
Cardiovascular gene list. Ruth’s
presentation generated a lively discussion about the inclusion of
high-throughput data in the GOC dataset.
To date, this initiative has associated over 5,000
GO terms to more than 600 proteins, of which 4,317 are to 438 human proteins. 132
prioritised genes have been comprehensively annotated using GO terms, including
AGT, CHRD, CST3, CYP26B1, CYP26C1, DRD2-4, ECE1, EDN2, G6PD, NOG, NOS1, NOS3,
RARA, RBP4, SOD2, SRF and TGFB2. Furthermore, a total of 24 genes have had first pass annotation
including AGT, DRD1, FKBP1A, FKBP1B, NRG1, NOS2A SIRT1, TGFBR2 and VEGFA. We hope to revisit these genes next year and
would welcome additional annotation suggestions from expert scientists.
Gene Ontology development
Over 90 cardiovascular issues have been raised
with the Gene Ontology Editorial team since the start of the project, resulting
in the creation of 183 new GO terms. Many of these requests have led to the
creation of new terms to describe the regulation of specific processes, such as
regulation of ventricular cardiomyocyte membrane repolarization, regulation of
sarcomere organization, regulation of respiratory burst during acute inflammatory
response, although some provide new cardiovascular relevant terms such as
cardiac epithelial to mesenchymal transition, elastin catabolic process.
GO Consortium Membership
In July the Cardiovascular GO Annotation
Initiative became one of 16 full members of the GO Consortium. For more information about the GO Consortium
members and associate members see http://www.geneontology.org/GO.consortiumlist.shtml.
The Gene Ontology - Providing a
functional role in Proteomic Studies
Emily C Dimmer, Rachael P Huntley, Daniel G Barrell, David Binns, Sorin Draghici, Evelyn B Camon, Mike Hubank, Philippa J Talmud, Rolf Apweiler, Ruth C Lovering. Proteomics 2008 July Epub. PMID: 18634107.
Access to immunology through the Gene Ontology
Ruth C Lovering, Evelyn B Camon, Judith A Blake, Alexander D Diehl.
Immunology 2008 Oct;125(2):154-60. PMID: 18798919.
In November Ruth will be attending the British Society for Immunology Congress taking place in Glasgow. She will be giving a short talk (“Imunology’s time to GO’) during the first plenary session and will have a poster in the registration area. If you are attending this meeting please come and discuss any GO issues with Ruth.
Page last modified on 01 oct 08 14:32
The work of the Cardiovascular Gene Annotation group is supported by British Heart Foundation grant RG/13/5/30112