Issue 22 - August 2013
Editor - Ruth Lovering
We are pleased to welcome two new biocurators, Dr Nancy Campbell and Dr Anna Melidoni, who join us this month. Both of them have considerable research experience and have demonstrated that they are able to quickly interpret a range of scientific data. Anna has worked on ES cells, including cardiac progenitors, for 9 years. Her PhD was undertaken at Queen Mary, University of London, in collaboration with UCL, working on the creation of Fmo5 knockout mice. Nancy has worked for 7 years in the anti-cancer drug discovery field, specifically working on X-ray crystallography and DNA-ligand interactions. Neither Nancy nor Anna have experience of annotating genes, so, during the next few months, they will be undertaking considerable training in biocuration.
Based on the EBI statistics, 20th July 2013, this project has associated 29,300 GO terms to 4,000 proteins,
20,200 of which are to 2,300 human proteins. Since
May Ruth has focused on the annotation of cardiac conduction proteins, using
the GO terms created during the Cardiac Conduction workshop held in November
2011. 43 proteins have now been fully annotated to the cardiac conduction
domain, including KCNH2 (hERG), SNTA1 (Alpha-1-syntrophin),
TRDN (Triadin), AKAP6, and PDE4D.
During the past few months, following ontology revisions, the GO Consortium has requested that GO annotators re-annotate proteins annotated to the ontology domains: cell cycle and apoptosis, as well as to the specific GO terms cell surface binding, postsynaptic density and flagellum assembly. Revisiting these annotations has lead to the editing of over 450 annotations, associated with 150 proteins and based on 200 papers.
Following our sixth 2 day GO Annotation Workshop Ruth has been working with Professor Christiana Ruhrberg, to fully annotate a selection of her published papers (PMID: 21658587, PMID:22790009 and PMID: 21828096). This work has led to the creation of 48 GO annotation and several new GO terms, including semaphorin-plexin signaling pathway involved in sympathetic axon guidance, sympathetic neuron projection extension and positive chemotaxis involved in neuron migration.
In April Ruth attended the International Society for Biocuration meeting (presenting a poster entitled ‘The impact of focused Gene Ontology annotation efforts on high-throughput data analysis’) and the GO Consortium meeting, both of which were held in Cambridge. Ruth also attended the Innovations in Cardiovascular Science Symposium at the UCL Institute of Child Health, in April.
Then in June Ruth attended the Annotating the Genome - BCGES Annual Meeting in conjunction with Statistics and South of England Genetic Epidemiology Group, giving a short presentation ‘Gene Ontology: progress and priorities for annotating the human genome’. Ruth also presented a poster at the Computational Life & Medical Sciences 3rd Annual Symposium, at UCL.
In October Ruth will be attending the GO Consortium meeting, Bar Harbor, Maine, US.
Page last modified on 02 aug 13 12:01
The work of the Cardiovascular Gene Annotation group is supported by British Heart Foundation grant RG/13/5/30112