Vascular dysfunction and abnormal vessel growth contribute to many different types of disease. For example, atherosclerosis can cause stroke or myocardial infarct, whilst microvascular abnormalities lead to vision loss in two common eye diseases, diabetic retinopathy and age-related macular degeneration. Accordingly, the study of vascular growth and homeostasis is of enormous clinical significance. Vascular research in the UCL Institute of Cardiovascular Science aims to identify genetic and environmental factors that promote atherosclerosis to improve prevention, but also to identify molecular and cellular mechanisms that may be targeted therapeutically to stimulate the growth of functional new vessels, block the growth of abnormal vessels or repair dysfunctional vessels. Our researchers have made many important discoveries that have helped to move forward non-invasive diagnosis, elucidate the origin of congenital vascular disease and advance our understanding of the signalling pathways that regulate microvessel growth.