UCL Institute of Cardiovascular Science

Through a transatlantic network of collaborating investigators funded by the Fondation Leducq, we are designing and constructing patient-specific multi-scale models of single ventricle physiology to guide surgical decision making and postoperative patient management. Specifically, we are using clinically obtained investigations and imaging to construct mathematical models of the entire cardiovascular system to assess local and global effects of the various surgical treatments of single ventricle hearts, and to understand the impact of the altered circulation on postoperative physiology in a patient-specific manner. 

Through collaboration with two US institutions, Medical University of South Carolina and University of South Carolina, funded by the American Heart Association, we are developing an integrated, miniaturized sensor that can be implanted to monitor intra-cardiac pressure and mixed venous saturation following paediatric cardiac surgery.