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People

Professor Harry Hemingway

Research Lead

Professor Harry Hemingway

Contact us

Clinical Epidemiology Group
1-19 Torrington Place, London WC1E 6BT

Academic Secretary: Giovanna Ceroni

Tel +44 (0)20 3108 3082

Clinical epidemiology of cardiovascular disease

Clinical Epidemiology of Cardiovascular Disease - There are 366, 487 dots on this map, each one represents a patient with a heart attack recorded in the Myocardial Ischaemia National Audit Project (MINAP), a failure of primary prevention and an opportunity for secondary prevention. Our research seeks to better understand remediable influences on outcome before, during and after admission to hospital. [map comes from Herrett E et al Heart 2010]

Overview

Professor Hemingway's research focuses on cardiovascular disease in populations. The work of his group aims to investigate the aetiology and prognosis of specific coronary phenotypes – rather than the aggregate of ‘CHD’ which may conceal important associations. There are three broad approaches to this work: establishing novel clinical cohorts, exploitation of linked electronic health records and methods development in prognosis research. 

Our research is funded by the Wellcome Trust, Medical Research Council, National Institute of Health Research and the European Commission Framework Programme 7.

Key research activities

Clinical Cohorts in Coronary Disease Collaboration (4C)

We are establishing a multi-centre cohort phenotyping and genotyping people with suspected and confirmed stable coronary disease, with follow up for coronary endpoints. This will allow a range of translational research questions to be addressed under different study designs appropriate to studying causes of disease onset (case-control), disease progression (cohort) and pharmacogenetic effects.  

Cardiovascular Disease Research Using Linked Bespoke Studies and Electronic Records (CALIBER)

CALIBER has linked differentiated acute coronary syndrome endpoints from MINAP (Myocardial Ischaemia National Audit Project) to the primary care record in GPRD (General Practice Research Database). This allows longitudinal investigation of risk and care, before, during and after and event. Linkages of MINAP to large investigator led cohorts, such as the UK Biobank, is planned. 

Prognosis Research Strategy Initiative (PROGRESS)

The MRC funded PROGRESS Partnership is an international, interdisciplinary collaboration developing understanding in research into prognostic factors, risk prediction models and predictors of differential treatment response (stratified medicine).