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UCL Institute of Cardiovascular Science

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Myocardial protection, Ischaemia-Reperfusion and Conditioning

Myo

Overview

Heart disease is the leading cause of death and disability in the world. The commonest form of heart disease affects the arteries supplying the heart muscle with blood, termed coronary artery disease (CAD). Blockages and narrowing in these arteries lead to heart muscle damage called ischemic heart disease. Ischaemic heart disease may cause premature death through heart attacks or disability when the heart pump becomes damaged and eventually fails. Investigating novel ways of protecting the heart from coronary artery & ischaemic heart disease is the major research objective of this research theme. The experimental basic science studies undertaken are crucial for identifying novel signalling pathways & targets to protect the heart. In addition, translating our basic science studies to clinical studies, for the benefit of patients, is equally a fundamental part of the research we undertake.

Key research activities

Conditioning the heart against ischaemia-reperfusion injury: bench to bedside
Cardiac Imaging from cell to man
Cell signalling pathways in cardioprotection
Mitochondria as targets for cardioprotection
Co-morbidities and cardioprotection