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People

Prof. William McKenna

Research lead

Prof William McKenna

PIs

Contact us

Centre for Inherited Cardiovascular Disease
The Heart Hospital
16-18 Westmoreland Street
London W1G 8PH 

Centre PA: Shaughan Dickie
Tel +44 (0)20 3456 4040

Inherited cardiovascular disease

Inherited cardiovascular disease

Overview

Heart disease in the young is often caused by an inherited genetic defect. UCL has a dedicated Inherited Cardiovascular Disease clinic working within two hospitals- Great Ormond Street Hospital for paediatric patients and the Heart Hospital for adults. Our clinics strive to translate novel development in genetics, imaging, heart failure, and arrhythmia research into improved diagnostics and management for families with inherited forms of cardiomyopathy and arrhythmia.

Key research activities

Using Genetics to Identify at Risk Individuals within Families with Inherited Heart Disease

Regular cardiac evaluation is performed on the offspring of affected individuals who usually will have a 1:2 or 1:4 chance of inheriting the disease causing mutation. Identification of the mutation permits targeted screening of those at risk and reassurance of those who do not carry the mutation. Studying Disease Development within Families to Identify Disease Markers and Targets for Treatment Current diagnostic criteria and concepts of inherited heart disease are based on full disease expression. Evaluation of the initial changes of disease development in genetically identified family members with preclinical disease will help identify targets for prevention strategies. Performing Clinical Trials of Novel Treatments with European (ESC WG), UK (QMUL, Aberdeen) and American (Yale) Partners Genetic and biomarker studies suggest potential pathogenetic pathways as targets for new treatments. The Centre has a critical mass of patients to enable pilot studies, but sufficiently powered trials will require multi-centre trials with our partners.

Regular cardiac evaluation is performed on the offspring of affected individuals who usually will have a 1:2 or 1:4 chance of inheriting the disease causing mutation. Identification of the mutation permits targeted screening of those at risk and reassurance of those who do not carry the mutation.

Studying Disease Development within Families to Identify Disease Markers and Targets for Treatment

Current diagnostic criteria and concepts of inherited heart disease are based on full disease expression. Evaluation of the initial changes of disease development in genetically identified family members with preclinical disease will help identify targets for prevention strategies.

Performing Clinical Trials of Novel Treatments with European (ESC WG), UK (QMUL, Aberdeen) and American (Yale) Partners

Genetic and biomarker studies suggest potential pathogenetic pathways as targets for new treatments. The Centre has a critical mass of patients to enable pilot studies, but sufficiently powered trials will require multi-centre trials with our partners.