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UCL Institute of Cardiovascular Science

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Heart rhythm disorders

heart rhythm disorders

Overview

Sudden cardiac death (SCD) from ventricular arrhythmias claims over 300,000 lives per year in the U.S. and over 50,000 lives per year in the UK. Despite a recent fall in mortality from cardiovascular disease, the proportion attributed to SCD is increasing. Ventricular tachy arrhythmias are the usual cause, often occurring without warning or provocation most commonly in patients with underlying cardiac disease. Efforts at prediction and prevention therefore have become of major importance in combating this significant public health and socioeconomic problem. The mechanisms of cardiac arrhythmias in a number of conditions including ischaemic heart disease, Brugada syndrome, Arrhythmogenic Right Ventricular Cardiomyopathy and Long QT Syndrome are studied by the Cardiac Electrophysiology Group. The group is focussed on identifying new genes responsible for causing sudden cardiac death, identifying new markers of risk in specific patient groups and optimising prevention & treatment strategies.

Key research activities

Using Genetics to Understand the Causes of Inherited Arrhythmia Syndromes
Understanding the Functional Basis of These Genetic Effects
Cell signalling pathways in cardioprotection
In-Vivo and Molecular Investigation of the Arrhythmogenic Mechanisms of Sudden Cardiac Death