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High-Throughput Serum NMR Metabolomics – from Systems Epidemiology to the Clinic?
Speaker: Prof. Mika Ala-Korpela, Professor of Computational Medicine, University of Oulu, Finland
Date: 17th December 2012
Time: 11.30-12.30 followed by a sandwich lunch for all attendees
Location: Seminar room, 2nd floor, Rayne Building, 5 University Street, London WC1E 6JF
Prof. Ala-Korpela has more than two decades of experience in biomedical NMR spectroscopy and has pioneered high-throughput applications of NMR-based metabolomics in molecular epidemiology and functional genetics. Under his lead Computational Medicine was selected as one of the strategic scientific areas for development and funding at the University of Oulu for 2012-2016. During the last 8 years his team has focused on developing an NMR-based metabolomics platform for human serum and plasma. This novel methodology has now been used to analyse over 100,000 serum samples (in about 4 years) and provides information on >100 primary metabolic measures and >100 derived variables with clear biochemical interpretation and significance. This platform has recently been applied in various large-scale epidemiological and genetic studies the results of which have been published in the leading scientific journals.