Tel: 020 76796549 (or x 46549)
The UCL Cancer Institute hosts external speakers, prominent in their fields of study, on Thursday evenings throughout the academic year.
The aims of these seminars are to discuss a range of topics relevant to cancer research, from fundamental research discoveries to translational applications, and we hope that these seminars will become a focus of social interaction between clinicians and scientists involved in cancer research across the UCL campus.
The general format is a 40-minute talk followed by a 10-minute discussion. A drinks reception will be held after each seminar.
Thursday 26th September at 4 pm in Courtyard Café, Paul O’Gorman Building
Host: Dr Tim Fenton (e-mail)
Professor Frank Furnari – University of California, San Diego, Dept. of Pathology
“EGF Receptor in Glioma Biology: Therapeutic Target and a Multifaceted Driver of Pathogenicity “
The formation of human tumors is a complex process involving the accumulation of genetic lesions in genes that normally regulate cell proliferation, differentiation and cell death. For glioblastoma (GBM), the most frequent CNS tumor in adults, these genetic lesions occur in a relatively defined order and include loss of heterozygosity for chromosome 17p, mutation of the p53 gene, overexpression of the platelet derived growth factor receptor (PDGFA receptor), allelic losses of chromosome 22q, 13q (inclusive of the RB1 locus), and 19q, deletion of the interferon alpha and beta and INK4a and 4b loci on chromosome 9p, losses of heterozygosity for chromosome 10 for which the phosphatase and tensin (PTEN) homology gene, located at 10q23.3 is a frequent target, and gene amplification of EGFR.
Data from many studies, including the recent Cancer Genome Atlas (TCGA) initiative of the NCI, show that both PTEN mutation and EGFR amplification/mutation are the most frequent of the genetic lesions found in GBMs. The focus Professor Furnari’s research group is to investigate the role of these two genetic lesions in the genesis of GBM and how they cooperate to promote therapeutic resistance commonly associated with this tumor type. Specifically, 1) how expression of a mutant form of EGFR (ΔEGFR) potentiates tumor heterogeneity and hence aggressiveness; 2) the role of this receptor in driving tumor maintenance; 3) how modulators of the PTEN/PI3K signaling axis influence the effectiveness of receptor-directed therapeutics; and, 4) deciphering parameters that regulate sensitivity to therapeutics directed at ΔEGFR, are projects actively pursued.
Professor Frank Furnari's webpage
All are welcome. A reception will be held after the seminar in the Courtyard Café, Paul O’Gorman Building.
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Speakers - Reuven Agami, Adam Baker, Carlos Caldas, Doug Hanahan, Paul Kellam, Dimitris Lagos, Andres Ramos, Stephanie Urschel, Andrea Ventura, Elena Vigorito, Yosef Yarden, Carlo Croce
Winter 2009 (pdf)
Speakers - Nicholas Wright, Richard Peto, Hilary Calvert, Peter Ell, Jack Cuzick, Andy Futreal, Caroline Hill, Peter Parker, Stephen Jackson, Ewan Birney
Spring 2009 (pdf)
Speakers - Simon Gayther, Sue Hadjur, Marianne Bronner-Fraser, Fiona Watt, Ruth Muschel, Anne Ridley, Steve Pollard, Rebecca Fitzgerald, Antonis Kirmizes, Michael Baum, Andy Futreal, Megan Cully
Winter 2008 (pdf)
Speakers - Tony Ng, Julie Cooper, Amanda Fisher, Barbara Jennings, Mark Lythgoe, Robert Brown, Julian Blow, Caroline Dive, James Brenton, Francesco Dazzi, Quentin Pankhurst
Summer 2008 (pdf)
Speakers - Julian Downward, Ian Hagan, Mieke Dewerchin, Jordan Raff, Silvia Marino, Gordon Jayson, Kim Nasmyth, Tony Carr
Winter 2007 (pdf)
Speakers - Hans Stauss, Chris Marshall, Ronjon Chakraverty, Bryan Young, Alison Lloyd, Charles Swanton, Buzz Baum, Andrew Tutt, Gareth Williams, Tariq Enver, Jane Wardle, Mike Stratton, Bart Vanhaesebroeck
Summer 2007 (pdf)
Speakers - Tim Hunt, Chris Boshoff, Kevin Harrington, Stephan Beck, John Anderson, Tim Crook, Adrian Harris, Xin Lu, Martin Widschwendter, Robin Weiss, Ron Laskey, Frank Uhlmann, Bruce Ponder