Enquiries to:
Kerry Wynn-Williams
Tel: 020 76796549 (or x 46549)
E-mail:
k.wynn-williams@ucl.ac.uk
The UCL Cancer Institute hosts external speakers, prominent in their fields of study, on Thursday evenings throughout the academic year.
The aims of these seminars are to discuss a range of topics relevant to cancer research, from fundamental research discoveries to translational applications, and we hope that these seminars will become a focus of social interaction between clinicians and scientists involved in cancer research across the UCL campus.
The general format is a 40-minute talk followed by a 10-minute discussion. A drinks reception will be held after each seminar.
Thursday 16th May at 5pm in the Courtyard Café, Paul O’Gorman Building
Professor Victor Tybulewicz –
MRC National Institute for Medical Research, London
“B cell survival and tonic signalling from the B cell antigen receptor“
Using gene knock-out technology and over a career spanning three decades, Dr. Tybulewicz has made a number of important contributions to our understanding of the function of various signal transduction proteins in the adaptive immune system. His group was also the first to generate a humanized mouse model of Down syndrome. His research interests are broadly divided into two areas.
Signal transduction from the antigen receptors of B and T cells
The Tybulewicz group is interested on signal transduction in B and T cells, from the antigen, chemokine and cytokine receptors, as well as integrins. Signals from these receptors play critical roles in B and T cell development, activation, migration, survival and death. His group is studying these processes, using a number of different techniques. These include gene targeting in ES cells and the generation of mutant mouse lines, protein biochemistry, imaging, RNAi screens, and structural biology. Over the last few years his group has focused on the following signaling proteins: the protein tyrosine kinase (PTK) Syk, the Guanine Nucleotide Exchange Factor (GEF) Vav1, and the small GTPases Rac1 and Rac2.
Mouse models of Down syndrome
Trisomy of human chromosome 21 (Hsa21) occurs in approx 1 in 750 live births, and the resulting gene dosage imbalance gives rise to Down syndrome (DS), the most common known genetic form of mental retardation. In collaboration with Prof. Elizabeth Fisher (Institute of Neurology, UCL) his group aims to identify dosage sensitive genes on Hsa21 which, when present in three copies, cause the many different phenotypes seen in DS. His group has created a novel mouse strain termed Tc1 which carries a freely segregating copy of Hsa21, and which shows defects in memory, synaptic plasticity, heart development, angiogenesis and in the craniofacial skeleton.
For further info homepage: Professor Victor Tybulewicz.
Host: Dr Steen Ooi – please contact Dr Ooi if you wish to meet with the speaker.
All are welcome. A reception will be held after the seminar.
Past Seminars
Autumn2012 (pdf)
Speakers - Prof Laurence Pearl, Prof Stephen Russell, Dr Helfrid Hochegger, Prof Kate Vallis, Dr Ricky Sharma, Prof Gerard Evan, Prof Bryan Cullen, Prof Genevieve Almouzni, Dr Rob Klose, Prof Victor Tybulewicz
Spring2012 (pdf)
Speakers - Dr Eric O’Neill, Professor Johann de Bono, Professor Johann de Bono, Dr Mikhail Spivakov, Dr Simon Cook, Professor Alan Ashworth, Professor Wendy Bickmore, Professor Paul Clarke, Dr Gordon Peters, Professor Neil Brockdorff, Dr Gareth Inman
Autumn2011 (pdf)
Speakers - Professor Timothy Bestor, Dr Paresh Vyas, Professor Eric So, Dr Kim Jensen, Dr Eyal Gottlieb, Professor Sarah Bray, Dr Nitzan Rosenfeld, Professor Pascal Meier, Dr Martin Zeidler, Professor Chris Marshall, Dr Andrew Bushell, Dr John Stingl, Professor Jordan Raff, Professor Hans Lehrach, Dr Ana Pombo
Spring2011 (pdf)
Speakers - Anne Ferguson-Smith, Professor Nick Proudfoot, Dr M Madan Babu, Professor Dave Tuveson, Professor Henk Stunnenberg
Spring2010 (pdf)
Speakers - Taija Makinen, Tony Kouzarides, Salvador Moncada, Mark Emberton and Mr Hashim Ahmed, Hing Leung, Nic Tapon, Margaret Ashcroft, Karim Malik, Gail Risbridger, Erik Sahai, Michael Streckel
Micro RNAs and Cancer Seminar 2010 (pdf)
Speakers - Reuven Agami, Adam Baker, Carlos Caldas, Doug Hanahan, Paul Kellam, Dimitris Lagos, Andres Ramos, Stephanie Urschel, Andrea Ventura, Elena Vigorito, Yosef Yarden, Carlo Croce
Winter 2009 (pdf)
Speakers - Nicholas Wright, Richard Peto, Hilary Calvert, Peter Ell, Jack Cuzick, Andy Futreal, Caroline Hill, Peter Parker, Stephen Jackson, Ewan Birney
Spring 2009 (pdf)
Speakers - Simon Gayther, Sue Hadjur, Marianne Bronner-Fraser, Fiona Watt, Ruth Muschel, Anne Ridley, Steve Pollard, Rebecca Fitzgerald, Antonis Kirmizes, Michael Baum, Andy Futreal, Megan Cully
Winter 2008 (pdf)
Speakers - Tony Ng, Julie Cooper, Amanda Fisher, Barbara Jennings, Mark Lythgoe, Robert Brown, Julian Blow, Caroline Dive, James Brenton, Francesco Dazzi, Quentin Pankhurst
Summer 2008 (pdf)
Speakers - Julian Downward, Ian Hagan, Mieke Dewerchin, Jordan Raff, Silvia Marino, Gordon Jayson, Kim Nasmyth, Tony Carr
Winter 2007 (pdf)
Speakers - Hans Stauss, Chris Marshall, Ronjon Chakraverty, Bryan Young, Alison Lloyd, Charles Swanton, Buzz Baum, Andrew Tutt, Gareth Williams, Tariq Enver, Jane Wardle, Mike Stratton, Bart Vanhaesebroeck
Summer 2007 (pdf)
Speakers - Tim Hunt, Chris Boshoff, Kevin Harrington, Stephan Beck, John Anderson, Tim Crook, Adrian Harris, Xin Lu, Martin Widschwendter, Robin Weiss, Ron Laskey, Frank Uhlmann, Bruce Ponder
