Publications

1. Franke, W.W., Mueller, M., Mittnacht, S., Kapprell, H-P. and Jorcano, J.L.: Significance of two Desmosome plaque Associated Polypeptides of Molecular Weight 75000 and 83.000. EMBO J., 2, 2221-2215, 1984.

2. Franke, W. W., Schmidt, E., Mittnacht, S., Grund, C. and Jorcano, J. L.: Experimental Manipulation of the Keratin Cytoskeleton: Integration of Different Kinds of Keratin into the same Filament System after Microinjection of mRNA for Epidermal Keratins into Kidney Epithelial Cells. Cell 36, 831-825, 1984.

3. Ankel, H., Mittnacht, S. and Jacobsen, H.: Antiviral Activity of Prostaglandin A on Encephalomyocarditis Virus Infected Cells: A Unique Effect Unrelated to Interferon. J. Gen Virol. 66, 2355-2364, 1985.

4. Mestan, J., Digel, W., Mittnacht, S., Blohm, D., Moeller, A., Jacobsen, H. and Kirchner, H.: In vitro Antiviral Effects of Recombinant Tumor Necrosis Factor. Nature 323, 861-819, 1986.

5. Domke, I., Poberschin, P., Mittnacht, S. and Kirchner, H.: Role of Interferon in Persistant Infection of Macrophages with Herpes Simplex Virus. Virology 159, 306-311, 1987.

6. Mittnacht, S. and Jacobsen, H.: Selection and Characterization of Interferon Sensitive Cells Derived from an Interferon Resistant NIH 3T3 Line. J. Gen. Virol. 68, 2945-2951, 1987.

7. Prozolt, F. Digel, W., Jacobsen, H., Mittnacht, S., Kirchner, H. and Heimpel, H.: Different Antitumor Mechanisms of Interferon Alpha in the Treatement of Hairy Cell Leukemia and Renal Cell Cancer. Cancer 61, 288-293, 1988.

8. Dirks, W., Mittnacht, S., Rentrop, M., and Hauser, H.: Isolation and Funktional Characterization of the Murine Interferon Beta Promotor. J. Interferon Res. 9, 125-133, 1988.

9. Mittnacht, S., Straub, P., Kirchner, H. and Jacobsen, H.: Interferon Treatement Inhibits onset of Herpes Simplex Virus Immediate Early Transcription. Virology 159 , 201-210, 1988.

10. Jacobsen, H., Mestan, J., Mittnacht, S. and Diffenbach, C.: Beta Interferon Subtype 1 Induction by Tumor Necrosis Factor. Mol. Cell. Biol. 9, 3037-3042, 1989.

11. Thiele, K., Mittnacht, S. and Kirchner, H.: Persistent Replication of Herpes Simplex Virus in Jok 1 cells. J. Gen. Virol. 68, 125-133, 1989.

12. Klotzbuecher, A., Mittnacht, S. Different Effects of Interferon Gamma and Interferon Alph/ Beta on Immediate Early Gene Expression of HSV-1. Virology 197, 487-491, 1990.

13. Mittnacht, S. and Weinberg, R. A.: G1/S Phosphorylation of the Retinoblastoma Protein is Associated with an Altered Affinity for the Nuclear Compartment. Cell 65, 381- 393, 1991.

14. Hinds P.W., Mittnacht S., Dulic V., Arnold A. Reed S. I., and Weinberg R. A.: Regulation of Retinoblastoma Protein Funktion by Ectopic Expression of Human Cyclins. Cell 70, 993-1006, 1992.

15. Mittnacht. S., Lees J. A., Desai D., Harlow E., Morgan D. O., and Weinberg R. A.: Distinct Subpopulations of the Retinoblastoma Protein Show a Distinct Pattern of Phosphorylation. EMBO J. 13, 118-127, 1994.

16. Steiner P., Philipp, A. Lukas, J., Godden-Kent, D., Pagano, M., Mittnacht, S., Bartek, J., and Eilers, M.: Identification of a myc dependent step during the formation of active G1 cyclin cdk complexes. EMBO J. 14, 4814- 4826, 1995.

17. Belbrahem, A., Godden-Kent, D., and Mittnacht, S.: Regulation and activity of the retinoblastoma protein family in growth factor derived and TGF beta-treated keratinocytes. Exp. Cell Res.225, 286-293, 1996.

18. Chang, Y., Moore, P.S., Talbot, S.J., Boshoff, C.H., Zarkowska, T., Godden-Kent, D., Patterson, H. Weiss, R.A., and Mittnacht, S.: Cyclin encoded by KS herpesvirus. correspondence, Nature 382, 410, 1996

19. Zarkowska, Z., U, S., Harlow, E., and Mittnacht S.: Monoclonal antibodies specific for underphosphorylated retinoblastoma protein identify a cell cycle regulated phosphorylation site targeted by CDKs. Oncogene 14, 249-254, 1997.

20. Godden-Kent, D., Talbot, S., Boshoff, C., Chang, Y., Moore, P., Weiss, R.A., and Mittnacht, S.: The cyclin encoded by Kaposis sarcoma-associated herpesvirus (KSHV) stimulates cdk6 to phosphorylate the retinoblastoma protein and Histone H1. J. Virol. 71, 4193-4198, 1997.

21. Mittnacht, S., Paterson, H., Olson, M. F., and Marchall, C.J,: Ras signalling is required for inactivation of the tumour supressor pRB cell cycle control protein. Current Biology 7, 219-221, 1997.

22. Zarkowska T., and Mittnacht, S.: Differential phosphorylation of the retinoblastoma protein by G1/S cyclin dependent kinases. J. Biol Chem. 272, 12738- 12746, 1997.

23. Chew Y.-P., Ellis M., Wilkie S., Mittnacht S.: Phosphorylation mutants reveal role of pRB in regulating S phase progression independent of E2F. Oncogene 17, 2177-2189, 1998.

24. Duro D., Schulze A., Bartek, J., Mittnacht, S., Jansen-Duerr, P.: Activation of Cyclin A gene expression by the cyclin encoded by Human Herpesvirus 8. J Gen Virol 80, 549-555, 1999

25. Paramio, J.M., Casanova, M.L, Segrelles, C., Mittnacht S., Lane, B. Jorcano, J.L.: Modulation of cell proliferation by Cytokeratins K10 and K16. Mol. Cell. Biol. 4 3086-3094, 1999.

26. Hsieh J-K., Chan F., O' Connor D. J., Mittnacht S., Zhong S., Lu X.: A novel trimeric complex of p53, mdm2 and pRB stabilises p53 and associates the apoptotic function of p53 to its transrepresssion but not transactivation function. Molecular Cell 3. 181-193, 1999.

27. Ellis, M., Chew, Y. P., Fallis, L., Freddersdorf, S., Boschoff, C., Weiss, R., Lu, X. Mittnacht, S. Degradation of p27(Kip) cdk inhibitor triggered by Kaposi's sarcoma virus cyclin-cdk6 complex. EMBO J. 18, 644-653, 1999.

28. Platt, G, Mittnacht, S and Schulz T: The Latent Nuclear Protein (LANA-1) of Kaposi’s sarcoma Herpesvirus (KSHV) interacts with RING3, a homologuue of the Drosophila Female Homeotic (FSH) Gene. J. Virol 73, 9789- 95, 1999

29. Barnouin, K., Fredersdorf, S., Eddaoudi, A., Mittnacht, S., Pan, L. X., Du, M. Q., and Lu, X. Antiproliferative function of p27kip1 is frequently inhibited in highly malignant Burkitt's lymphoma cells. Oncogene 18, 6388-97.1999

30. Tamrakar S., Mittnacht S. and Ludlow JW. Binding of Select Forms of pRB to Protein Phosphatase Type 1 Independent of Catalytic Activity. Oncogene 18.7803 -09 1999

31. Platt GM, Cannell E, Cuomo ME, Singh S, Mittnacht S.: Detection of the Human Herpesvirus 8-Encoded Cyclin Protein in Primary Effusion Lymphoma-Derived Cell Lines. Virology 272. 257-266. 2000

32. Rubin E, Mittnacht S, Villa-Moruzzi E, Ludlow JW.Site-specific and temporally-regulated retinoblastoma protein dephosphorylation by protein phosphatase type 1. Oncogene 28;20(29):3776-85. 2001

33. Platt, G., Carbone, A., Mittnacht, S.. p16INK4a loss and sensitivity in KSHV associated primary effusion lymphoma. Oncogene 21, 1823-1831. 2002

34. Broceño, C., Wilkie, S., and Mittnacht S. RB activation defect in tumour cell lines. Proc Natl Acad Sci U S A Oct 29;99(22):14200-5, 2002

35. Xiao B, Spencer J, Clements A, Ali-Khan N, Mittnacht S, Broceno C, Burghammer M, Perrakis A, Marmorstein R, Gamblin SJ. Crystal structure of the retinoblastoma tumor suppressor protein bound to E2F and the molecular basis of its regulation. Proc Natl Acad Sci U S A. Mar 4;100 (5):2363-8. 2003

36. Bettencourt-Dias M, Mittnacht S, Brockes JP. Heterogeneous proliferative potential in regenerative adult newt cardiomyocytes. J Cell Sci. Oct 1;116(Pt 19):4001-9. 2003

37. Barrie SE, Eno-Amooquaye E, Hardcastle A, Platt G, Richards J, Bedford D, Workman P, Aherne W, Mittnacht S, Garrett MD. High-throughput screening for the identification of small-molecule inhibitors of retinoblastoma protein phosphorylation in cells. Anal Biochem. 320(1):66-74. 2003

38. Sanchez-Sanchez, F., Kruetzfeldt, M., Najera, C. and Mittnacht, S. A novel constitutional mutation affecting splicing of retinoblastoma tumor suppressor gene intron 23 causes partial loss of pRB activity. Hum Mutat. 25, 223. 2005

39. Krutzfeldt, M., Ellis, M., Weekes, D.B., Bull, J.J., Eilers, M., Vivanco, M.D., Sellers, W.R. and Mittnacht, S. Selective Ablation of Retinoblastoma Protein Function by the RET Finger Protein. Mol Cell. 18, 213-24. 2005

40. Cuomo M.E., Kneber A., Platt G., Morrice N., Cohen P. and Mittnacht S. Regulation of microfilament organization by KSHV- cyclin/ cdk phosphorylation of caldesmon.. J. Biol Chem. 280, 35844-58. 2005

41. Vietri M, Bianchi M, Ludlow JW, Mittnacht S, Villa-Moruzzi E. (2006) Direct interaction between the catalytic subunit of Protein Phosphatase 1 and pRb. Cancer Cell International, 6(1):3. 2006

42. Sánchez-Sánchez F, Ramírez-Castillejo C, Weekes DB, Beneyto M, Félix Prieto F, Nájera C., Mittnacht S. Attenuation of disease phenotype through alternative translation initiation in low penetrance retinoblastoma. Hum Mutat. 28(2):159-167. 2007

43. Oliver, A.W., A. Paul, K.J. Boxall, S.E. Barrie, G.W. Aherne, M.D. Garrett, S. Mittnacht, and L.H. Pearl, Trans-activation of the DNA-damage signalling protein kinase Chk2 by T-loop exchange. Embo J, 25 3179-90, 2006

44. Hassler, M., Singh, S., Yue, W.W., Luczynski, M., Lakbir, R., Sanchez-Sanchez, F., Bader, T., Pearl, L.H., and Mittnacht, S. Crystal structure of the retinoblastoma protein N domain provides insight into tumor suppression, ligand interaction, and holoprotein architecture. Mol Cell 28, 371-385. 2007

45. Petrie, K., Guidez, F., Zhu, J., Howell, L., Owen, G., Chew, Y.P., Parks, S., Waxman, S., Licht, J., Mittnacht, S., Zelent A. Retinoblastoma protein and the leukemia-associated PLZF transcription factor interact to repress target gene promoters. Oncogene 27, 5260-5266. 2008

46. Cuomo, M.E., Knebel, A., Morrice, N., Paterson, H., Cohen, P., and Mittnacht, S. (2008). p53-Driven apoptosis limits centrosome amplification and genomic instability downstream of NPM1 phosphorylation. Nat Cell Biol 10, 723-730. 2008

47. Cuomo, M.E., Platt, G.M., Pearl, L.H., and Mittnacht, S. Cyclin/ CDK regulatory response is linked to substrate recognition. J Biol Chem. 2011



Book Chapters and Invited Contributions

1. Franke, W.W., Schiller, D.L., Hatzfeld, M., Magin, T. M., Jorcano, J.L., Mittnacht, S., Schmid, E., Cohlberg, J.A. and Quinlan, R.A.: Cytokeratins. Complex Formation, Biosynthesis and Interaction with Desmosomes. Cancer Cell 1, Cold Spring Harbor Laboratories. NY, 177-190, 1984.

2. Geiger, B., Gigi, O., Kreis, T.E., Schmid, E., Jorcano, J.L., Mittnacht, S. and Franke, W.W.: Dynamic Rearrangement of Cytokeratin Polypeptides in Cells. Cancer Cell 1, Cold Spring Harbor Laboratories, Ny, 201-215, 1984.

3. Mittnacht, S. and Jacobsen, H.: Anlysis of Interferon Sensitive Revertants, Selected from an Interferon Resistant NIH 3T3 Line. The Biology of the Interferon System 1985. Eds.: W.E. Steward, H Schellekens, Elsevier Science Publishers, 143-146, 1986.

4. Mittnacht, S. Templeton, D. J., and Weinberg, R. A.: Funktioning of the Retinoblastoma Gene. General Motor Cancer Research Foundation, Accomplishments in Cancer Research 1990, 197-202, Philadelphia, J.B. Lippscott, 1991.

5. Mittnacht, S., Hinds, P. W., Dowdy, S. F., and Weinberg, R. A.: Modulation of Retinoblastoma Protein Activity during the Cell Cycle. In: Cold Spring Harbor Symposia on Quantitative Biology. The Cell Cycle, Volume 56., 1992.

6. Cobrinic D., Dowdy S., Hinds P. W., Mittnacht, S., and Weinberg R. A.: The Retinoblastoma Protein and the Regulation of the Cell Cycle. TIBS 17, 312- 315, 1992.

7. Mittnacht. S: Control of pRB phosphorylation. Curr-Opin-Genet-Dev. 8(1): 21-7, 1998.

8. Cannell, E., Mittnacht, S.: Virally Encoded Cyclin Proteins. Seminars in Cancer Biology, 9. 221-229, 1999.

9. Mittnacht, S and Boshoff, C.: Viral Cyclins. Reviews in Medical Virology 10, 175-184. 2000

10. Mittnacht S with Aasland R, Weinzierl RO, Dawson E, Jones M, Benton R, Tsang M, Huckriede N, Ferea T. Paper Alert. Genetics and development. Curr Opin Genet Dev. Recurrent contribution (quarterly, 1999-2001)

11. Garrett MD, Mittnacht S.: Oncogenes and cell proliferation The genetics and biology of cancer - revealing avenues for therapy. Editorial. Curr Opin Genet 15(1) 1-4. 2005

12. Mittnacht S. The retinoblastoma protein-from bench to bedside. Eur J Cell Biol. 84, 97-107. 2005

13. Sánchez-Sánchez F, Mittnacht S. Nonsense-mediated decay: paving the road for genome diversification. Bioessays. 30(10): 926-8. 2008