Department of Research Pathology in the Division of Cancer Studies

The Current Head of Department is Professor Gareth H Williams, Bland Sutton Chair of Pathology & CRUK Senior Scientist Head The current clinical lead is Dr Mary Falzon.

The department processes approximately ? 75,000 surgical biopsies per year with ? autopsies. There is a high proportion of specialised work. Cancer services are organised with a named lead consultant histopathologist for each responsible for implementing national reporting guidelines and providing input into multidisciplinary clinico-pathological meetings. Key cancer sites are head and neck, upper gastrointestinal tract, colorectal, breast, urological, hepato-biliary/pancreas, haematolymphoid and skin cancer. Cytopathology processes around ???? gynae and ???? non-gynaecological specimens per year.

Research degrees MPhil, PhD, MD

There is a strong focus on basic science and clinical research. We are exploiting state of the art molecular and cellular biological techniques to determine the causes, analyse the effects, and develop means for the early detection and treatment of diseases of medical and social importance. The translational research exploits the diagnostic strengths of the department which receives over 72,000 samples of pathological human tissues and cells per year, covering the full spectrum of human disease.

Research falls into the following broad themes for which supervision is available

Chromosomal Replication: study of the role of the DNA replication licensing pathway in coordinating growth and differentiation during normal tissue development and maintenance, and how these mechanisms become deregulated in cancer. This involves exploitation of a novel family of cell-free DNA replication systems which allows direct analysis of the DNA replication licensing machinery in human cells.

Structural Medicine: biochemistry, biophysics, and structural biology are exploited to study the protein-protein and protein-DNA interactions at chromosomal origins to provide a detailed molecular picture of how DNA replication is regulated during the cell cycle. In collaboration with medicinal chemists at the Wolfson Institute for Biomedical Research, we are developing therapeutic anti-cancer agents targeting the DNA licensing pathway.

Molecular Cancer Diagnostics: In a joint venture with Novocastra the department has established a state of the art molecular diagnostics laboratory (UCL Advanced Diagnostics Ltd link to UCLAD website..........

Comment re UCLAD  

which is investigating the use of molecular markers in cancer diagnosis and screening.

Stem cell biology and clonality: stem cell biology and tumour clonality are being used to exploit mouse model systems and novel molecular approaches for the analysis of human tissues and tumours.

Lymphoproliferative/leukaemogenesis: the pathology and biology of lymphoproliferative diseases is studied using molecular cell biology and immunophenotyping techniques.