Diffusion MRI

Water in living tissue is generally constrained to compartments with a characteristic size. MRI can be sensitised to the inherent motion (diffusion) of water, which can be used to probe the size and shape of the compartment. In collaboration with the UCL Microstructure Imaging Group we are developing tools for measuring and quantifying tumour microstructure using diffusion MRI.
T2-weighted, ADC and perfusion images in a tumour cross-section

Figure 1: (Left to right) T2-weighted, apparent diffusion coefficient (ADC), and perfusion images from cross-section through a colorectal tumour xenograft.

Associated publications:

Walker-Samuel S, Orton M, Boult JK, Robinson SP. Improving apparent diffusion coefficient estimates and elucidating tumor heterogeneity using Bayesian adaptive smoothing. Magn Reson Med 2011;65(2):438-447. [link]

Walker-Samuel S, Orton M, McPhail LD, Robinson SP. Robust estimation of the apparent diffusion coefficient (ADC) in heterogeneous solid tumors. Magn Reson Med 2009;62(2):420-429.

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