Image of the Month

Image of the Month


Photoacoustic imaging from CABI on the front cover of nature photonics. Click the image to read the article.

Image of the Month

Every month we'll publish a new image taken by CABI researchers. Can you guess what it is?


WHAT: Cross section of an LS174T colorectal carcinoma xenograft

SIZE: Approx. 10mm in diameter

IMAGE: Multi-channel fluorescence microscopy (16352x14290 pixels)

USE: Hoechst 33342 (blue) is a perfusion marker which shows the area of perfused blood vessels in the tumour at the time of injection (i.v.). 

CD31 (red) is a marker of endothelial cells, it stains the blood vessels. Upon appropriate thresholding to eliminate background signal, tumour vascular density and perfusion fraction can be quantified. This represents a valuable assessment for comparing the characteristics of different tumour types, or to assess the evolution of the tumour microenvironment upon antiangiogenic therapy, for example.

WHO: Miguel Gonçalves

Image of the Month Archive

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