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Image of the MonthTweets by @CABI_UCL
Image of the Month
Every month we'll publish a new image taken by CABI researchers. Can you guess what it is?
WHAT: Cross section of an LS174T colorectal carcinoma xenograft
SIZE: Approx. 10mm in diameter
IMAGE: Multi-channel fluorescence microscopy (16352x14290 pixels)
USE: Hoechst 33342 (blue) is a perfusion marker which shows the area of perfused blood vessels in the tumour at the time of injection (i.v.).
CD31 (red) is a marker of endothelial cells, it stains the blood vessels. Upon appropriate thresholding to eliminate background signal, tumour vascular density and perfusion fraction can be quantified. This represents a valuable assessment for comparing the characteristics of different tumour types, or to assess the evolution of the tumour microenvironment upon antiangiogenic therapy, for example.
WHO: Miguel Gonçalves
Image of the Month Archive
Page last modified on 10 jul 15 16:05