The Brodsky laboratory investigates the biochemistry, cell biology and physiological functions of clathrin proteins, with particular focus on:
- The molecular basis for clathrin function.
- Clathrin proteins' roles in physiology, including lymphocyte function, glucose metabolism and oncogenesis, and potential therapeutic value.
- The genetic diversity and evolutionary origins of the clathrin proteins, and the functional consequences of clathrin subunit diversity.
Towards these goals, we employ a range of scientific techniques, including biochemical analysis, protein production and purification, mass spectrometry, tissue culture and cellular assays, electron and confocal light microscopy, physiological models and human and evolutionary genetics.
" Studying the remarkable self-assembling clathrin proteins has led us in diverse research directions, crossing interfaces between biochemistry, cell biology, immunology and metabolism. It is exciting and gratifying that our basic molecular studies are now revealing intracellular mechanisms and pathways that are directly relevant to several human diseases including infection, Type 2 Diabetes and cancer. - Frances Brodsky -