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Design of Experiments for Bioprocess Optimisation

Design of Experiments

Learn how experimental design techniques can be used to rapidly understand and optimise bioprocess performance.

12-14 March 2018

This module shows laboratory scientists and engineers how experimental design techniques can be used to rapidly understand and optimise bioprocess performance.

It provides managers with insights on how experimental design and small scale experimental models can underpin Quality by Design (QbD) approaches. Training is focused on the hands on use of DoE software rather than underlying statistics. Bioprocess case studies, supported by a series of introductory and expert lectures will enable you to:

• Generate appropriate experimental designs within fixed research budgets and timescales.
• Ensure analytical methods can be validated and provide reliable data for process evaluation.
• Rapidly screen and optimise different fermentation media and operating conditions.
• Obtain the highest yield of active product throughout your downstream process sequence.
• Understand the relationship between DoE and QbD.
• Network with sector leaders and subject matter experts.

Who should attend?

The course is designed for all those involved in bioprocess development and optimisation including:

  • Bioprocess applications specialists
  • Hands-on bioprocess scientists and engineers
  • Research managers and consultants

Programme

Day 1
• Introduction to module and design of experiments
• Introduction to experimental design techniques and software
• Case studies: analytical method validation (OFAT vs DoE)
• Case Study: Analytical method development
• Industrial analytical method validation using DoE

Day 2
• Screening and optimisation of microbial fermentations
• Case study: fermentation process screening
• Case study: fermentation process optimisation and scaleup
• Protein refolding, stabilisation and formulation: structural and
environmental parameters that impact on maintenance and
stabilisation of protein structure and activity
• Development of a Quality by Design (QbD) pharmaceutical
production process using sequential DoE methodology

Day 3
• Case study: primary product recovery by microfiltration
• The application of factorial design in high throughput scale-down
bioprocess development: examples in fermentation and cell culture
• DoE and the multivariate consequences for bioprocess development
• Discussion forum

UCL Experts

Prof Gary Lye - Module Leader
Dr Frank Baganz
Prof Daniel Bracewell
Prof Paul Dalby

Previous Expert Speakers Include

• Sunil Chhatre, Sartorius Stedim
• Craig Gershater, Synthace Ltd
• Sue Connor, PRISM
• Patrick Jackson, GSK
• Daniel Tray, GSK

A social networking event will be held for delegates and speakers

For further information and bookings please contact:
E: mbi-training@ucl.ac.uk
T: +44 (0) 20 7679 9619 I +44 (0) 203 549 5619

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