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Biochemical Engineering

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Dr Hongyu Zhang

Post-Doctoral Research Associate

Education

  • University of Bristol (BSc) 2008-2011
  • University of Cambridge (PhD) 2011-2016

Research Interests

Coformulation of therapeutic proteins is increasingly popular in biopharmaceutics R&D. However, the analysis of the minor component is very challenging as the spectroscopic signal of the formulation is predominated by the major component. I use antibodies and their fragments as model systems to develop a high-resolution analytical method to investigate the mechanism of aggregation, particularly for the minor component, in this coformulation. 

Selected Publications

  1. Lou SC, Wetzel S, Zhang H, Crone EW, Lee YT, Jackson. SE and Hsu ST. The knotted protein UCH-L1 exhibits partially unfolded forms under native conditions that share common structural features with its kinetic folding intermediates J. Mol Biol (2016) 428(11):2507-20. 
  2. Zhang H, Jackson S Characterization of the Folding of a 52-Knotted Protein Using Engineered Single-Tryptophan Variants Biophysical Journal (2016) vol 111(12) pp: 2587-2599

Dr Hongyu Zhang

Dr Hongyu Zhang

Address

ACBE
Bernard Katz Building
UCL
London
WC1E 6BT

Appointments

  • Research Associate
    Dept of Biochemical Engineering
    Faculty of Engineering Science

Joined UCL

2016-11-28

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