Dr Cheng Zhang
Post-Doctoral Research Associate
- PhD in Biochemical Engineering, UCL, UK (2012-2017)
- MRes in Biochemical Engineering, UCL, UK (2011-2012)
- BEng in Biochemical Engineering, Zhejiang University of Technology, China (2007-2011)
My work aims to evaluate the relationships between Tm, fraction unfolded, and aggregation kinetics across a range of protein variants and formulations. The work is carried out based on two hypotheses
1. The Tm could predict the aggregation rates accurately only when unfolded proteins dominate the population at the storage condition. If the storage condition is much lower than the Tm, the correlation between Tm and aggregation rate is very poor.
2. Predictive tools, including protein modelling and simulation software, could be used to rationally guide the in vitro mutagenesis work, or formulation excipient choices, so as to reduce the aggregation and increase the thermal stability.
- Yu, H., Yan, Y., Zhang, C., & Dalby, P. A. (2017). Two strategies to engineer flexible loops for improved enzyme thermostability. Scientific Reports, 7, 41212. http://doi.org/10.1038/srep41212
- Barata, T. S., Zhang, C., Dalby, P. A., Brocchini, S., & Zloh, M. (2016). Identification of Protein–Excipient Interaction Hotspots Using Computational Approaches. International Journal of Molecular Sciences, 17(6), 853. http://doi.org/10.3390/ijms17060853
Dept of Biochemical Engineering
Faculty of Engineering Science
Bachelor of Engineering