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Biochemical Engineering

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Dr Cheng Zhang

Post-Doctoral Research Associate

Education

  • PhD in Biochemical Engineering, UCL, UK (2012-2017)
  • MRes in Biochemical Engineering, UCL, UK (2011-2012)
  • BEng in Biochemical Engineering, Zhejiang University of Technology, China (2007-2011)

Research Interests

My work aims to evaluate the relationships between Tm, fraction unfolded, and aggregation kinetics across a range of protein variants and formulations. The work is carried out based on two hypotheses

1. The Tm could predict the aggregation rates accurately only when unfolded proteins dominate the population at the storage condition. If the storage condition is much lower than the Tm, the correlation between Tm and aggregation rate is very poor.

2. Predictive tools, including protein modelling and simulation software, could be used to rationally guide the in vitro mutagenesis work, or formulation excipient choices, so as to reduce the aggregation and increase the thermal stability. 

Selected Publications

  • Yu, H., Yan, Y., Zhang, C., & Dalby, P. A. (2017). Two strategies to engineer flexible loops for improved enzyme thermostability. Scientific Reports, 7, 41212. http://doi.org/10.1038/srep41212
  • Barata, T. S., Zhang, C., Dalby, P. A., Brocchini, S., & Zloh, M. (2016). Identification of Protein–Excipient Interaction Hotspots Using Computational Approaches. International Journal of Molecular Sciences, 17(6), 853. http://doi.org/10.3390/ijms17060853

Dr Cheng Zhang

Dr Cheng Zhang

Appointments

  • Research Associate
    Dept of Biochemical Engineering
    Faculty of Engineering Science

Joined UCL

2016-12-12

Award year Qualification Institution
2011 BEng
Bachelor of Engineering
Biochemical Engineering
Not stated