XClose

Biochemical Engineering

Home
Menu

Dr Shaleem Jacob

Post-Doctoral Research Associate

Dr Shaleem Jacob

Education

  • Ph.D. in Chemical Engineering and Biotechnology, University of Cambridge
  • M.Eng. in Biochemical Engineering, UCL
  • Masters Year at University of Illinois at Urbana-Champaign

Research Interests

My research focuses on the process development and downstream processing of rotavirus vaccines. The consortium project entitled “Ultra-low cost, Transferable Automated Platform for Vaccine Manufacture (ULTRA),” aims to create a generic, low-cost, manufacturing platform that standardises the development and production of new recombinant protein vaccines for less than 15 cents a dose. 

Publications

  • Jacob, S. I., Khogeer, B., Bampos, N., Sheppard, T. D., Schwartz, R. M., & Lowe, C. R. (2017). The development and application of synthetic affinity ligands for the purification of ferritin-based influenza antigens. Bioconjugate Chemistry.
  • Jacob, S.I., Fairman, S., Catherine, N., Khogeer, B., Bampos, N., & Lowe, C. R. (2017). Purification of recombinant influenza antigens using a synthetic multicomponent Ugi affinity ligand. International Journal of Biological Molecules, (pending)
  • Khoury, G. E., Khogeer, B., Chen, C., Ng, K. T., Jacob, S. I., & Lowe, C. R. (2015). Bespoke affinity ligands for the purification of therapeutic proteins. Pharmaceutical Bioprocessing, 3(2), 139-152.
  • El Khoury, G., Wang, Y., Wang, D., Jacob, S. I., & Lowe, C. R. (2013). Design, synthesis, and assessment of a de novo affinity adsorbent for the purification of recombinant human erythropoietin. Biotechnology and bioengineering, 110(11), 3063-3069.

Dr Shaleem Jacob

Dr Shaleem Jacob

Address

UCL Department of Biochemical Engineering
Bernard Katz Building
London
WC1E 6BT

Appointments

  • Research Associate
    Dept of Biochemical Engineering
    Faculty of Engineering Science

Joined UCL

2017-01-09

My research focuses on the process development and downstream processing of rotavirus vaccines. The consortium project entitled “Ultra-low cost, Transferable Automated Platform for Vaccine Manufacture (ULTRA),” aims to create a generic, low-cost, manufacturing platform that standardises the development and production of new recombinant protein vaccines for less than 15 cents a dose. 

Award year Qualification Institution
2016 PhD
Doctor of Philosophy
Chemical Engineering and Biotechnology
University of Cambridge
2012 MEng
Master of Engineering
Biochemical Engineering
University College London

I completed my undergraduate studies (M.Eng.) in biochemical engineering from UCL and master year abroad from the University of Illinois at Urbana-Champaign. For my Ph.D., I joined the healthcare biotechnology group at the Department of Chemical Engineering and Biotechnology, University of Cambridge. This research was in collaboration and funded by the Vaccine Production Program Lab at the National Institutes of Health. The prime focus of this research was to design, synthesise and evaluate synthetic affinity ligands for the purification of recombinant influenza antigens. Two successful ligands from the multicomponent Ugi library were selected for purification as a result of this research.