Dr Stephen Goldrick
Postdoctoral Research Associate
- +44 (0) 20 7679 3796
- EngD in Biopharmaceutical Process Development, Newcastle University.
- MEngSc in Chemical and Bioprocessing Engineering, joint venture between Rice University and University College Dublin
- BEng in Chemical and Bioprocess Engineering, University College Dublin
My research interests lie in the application of multivariate data analysis and first principle mathematical modelling to the biotechnology sector. I am currently working in the UCL-MedImmune Centre of Excellence as a research associate specialising in bioprocess multivariate statistics and chemometrics. This project involves analysing data sets from both upstream and downstream processing to evaluate process operation improvements and optimise final product titres.
Previously I have developing a first a principles mathematical model of a 100,00 litre penicillin fermentation process. The simulation is freely available to download from www.industrialpenicillinsimulation.com and aims to serve as a valuable tool in the development of improved control strategies for industrial fermentations and can also be used for research and educational activities in monitoring, control and optimisation studies.
Additionally, I am interested in the application of Process
Analytical Technology (PAT) methodology to the bioprocess sector. Previous
experience includes the application of Raman spectroscopy for the on-line estimation
of critical process parameters (CCPs) and critical quality attributes (CQAs) of
a small-scale bacterial fermentation.
Goldrick, S., Stefan, A., Montague G., Lovett D., Lennox, B.
“The development of an industrial-scale fed-batch fermentation
simulation", Journal of Biotechnology Dec 2014
Goldrick, S., Mercer, E., Montague G., Lovett D., Lennox, B.
“Control of an Industrial Scale Bioreactor using a PAT Analyser." IFAC,
Goldrick, S., Lennox, B., Lovett, Smith, K., D. and
Montague, G. “The Development of a Simulation to Address the Real Challenges
Associated with Industrial Scale Penicillin Production." Computer Aided
Biotechnology/ Dycops, December 2013.
Goldrick, S., Smith, K., Lennox, B., Lovett, D. and Montague, G. “An investigation into sub-optimal control on the downstream processing of a large-scale industrial process“ UKACC Control Conference, Sep 2012