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Biochemical Engineering

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Dr Frank Baganz

Senior Lecturer

Chair of the Doctoral Committee

Dr Frank Baganz
  • Post-Doctoral Research Associate, UCL (1998-1999)
  • Lecturer in Biochemical Engineering, UCL (1999-2005)
  • Member, SCI Biotechnology Subject Group Committee
  • Member, Society of General Microbiology
  • Associate Member of the Institution of Chemical Engineers
  • Associate Editor, Journal of Chemical Technology and Biotechnology

Dr Frank Baganz

Address

2.6 Bernard Katz Building
Department of Biochemical Engineering
Torrington Place
London
WC1E 7JE

Appointments

  • Senior Lecturer
    Dept of Biochemical Engineering
    Faculty of Engineering Science

Joined UCL

1998-03-01

Frank’s research is focused on modelling, engineering and scale-up/down of fermentation, cell culture and biocatalytic processes. A major aim of the research is to mimic the environmental conditions that the cells are exposed to at the large/industrial scale in miniature bioreactor systems in order to better understand the cell response and thereby improve the manufacturing process using computer simulations and experimental approaches. In collaboration with Professor Gary Lye, he pioneered the use of microwell-based techniques to acquire information about fermentation and bioconversion. In particular, he established the engineering fundamentals of mixing and oxygen transfer in microwells and developed novel miniaturised bioreactors. His research also demonstrated the feasibility of predictive scale up from micro/mini reactors to lab scale reactors using established methods. He continues this work as part of the IMRC in Bioprocessing where he developed a platform for scale-down of industrial fermentation and cell culture processes in miniature bioreactors and microwells. In recognition for his contributions to this area he received the 2010 Pharmaceuticals Division Plenary Award of the AIChE. The micro/mini bioreactor work is complemented by detailed characterisation of fermentation and cell culture processes at lab scale and its integration with downstream processing for processing of macromolecules. Frank is a co-investigator of the multi-faculty Bioconversion-Chemistry-Engineering Interface programme (BiCE) led by Prof. Gary Lye that is concerned with the development of novel tools integrating chemistry, biology and engineering to accelerate development of biocatalytic processes. The main focus of his research is on modelling and optimisation of enzyme-catalysed reactions and construction of de novo pathways for synthesis of complex chiral molecules. To enable this he developed an immobilised enzyme microreactor for rapid determination of enzyme kinetics and analysis of de novo pathways. One of the aims is to identify enzyme combinations for integration into whole cell systems that could be used for industrial applications. The metabolic engineering of the whole cell biocatalysts is carried out in collaboration with Professor John Ward (Institute of Structural and Molecular Biology) and Dr Darren Nesbeth. The enginering work is aided by use of microwell approaches and statistical experimental design methods to identify process bottlenecks. Recently he established research in the area of algal biotechnology. Working in close collaboration with Dr Saul Purton (ISMB) he is assessing the potential of microalgae for recombinant protein synthesis and the production and recovery of biofuels using scale-down approaches for cell and process characterisation. Funding for the above research has come from the UK BBSRC, EPSRC and a range of company collaborators.
Award year Qualification Institution
1997 PhD
Doctor of Philosophy
Yeast Molecular Biology and Fermentation
University of Manchester Institute of Science and Technology
1994 Dipl. Ing.
Diplom- Ingenieur
Biotechnology and Biochemical Engineering
Fachhochschule Ostfriesland, Emden

Teaching and Training Activities

Frank’s current teaching activities focuses on fermentation and bioreactor design/engineering and cover both undergraduate and postgraduate degree programmes operated by the Department. He also teaches on a number of the department's post-experienceMBI® training modules covering aspects of fermentation, metabolic engineering and experimental design. In addition he coordinates the MBI® module of Rapid Fermentation Process Design.

In terms of administrative roles Frank is Tutor of the MSc students which involves monitoring academic progress and pastoral care. He also chairs the Departmental Safety Committee.