Successful Bioreactor Mixing

This course focuses on how to define conditions for the successful scale-up or scale-down of a fermentation process. It considers how to calculate the power input required for agitation in a stirred-tank fermenter under a range of operating conditions, and the impact of mixing and power input on oxygen transfer in aerobic fermentations and on different types of cells.

Course Overview

  • Introduction
  • Quantification of Mixing Phenomena in Stirred Vessels
  • What you will Learn
  • Case Study Outline
  • Effect of Aeration on Power Input
  • The Influence of Power Input on Oxygen Transfer
  • The Influence of Agitation on Cells
  • Fermenter Scale-Down
  • Rules of Thumb for Scaling
  • Other Relevant Stirred Vessels
  • Appraisal

What you will learn

The learning outcomes of this course are:

  • To be able to calculate the power input required for agitation in a stirred-tank fermenter under a range of operating conditions
  • To be able to define conditions for the successful scale-up or scale-down of a fermentation process
  • To have an understanding of the impact of mixing and power input on oxygen transfer in aerobic fermentations and on different types of cells
  • To have an understanding of how the operation of the fermenter can impact on the initial stages of product recovery

Sample pages

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Page last modified on 02 aug 08 20:14