Rapid Fermentation Process Design


Focusing on rapid fermentation process development and scale-up

October 2016

This module focuses on rapid fermentation process development and scale-up, through a series of lectures and case studies enabling you to:

  • Understand engineering principles of fermentation.
  • Determine power consumption and oxygen mass transfer.
  • Evaluate different strategies for scale-up and scale-down.
  • Know about miniaturised bioreactors and their role in fermentation process development.
  • Understand how to design a bioreactor and use data from microscale experiments for scaleup.

Who should attend?

Fermentation scientists and engineers in biotechnology and biopharmaceutical companies’ or similar who are involved in process transfer to manufacturers and also those in established fermentation development groups wishing to be kept up to date with the latest research in this area.


Day 1
• Introduction to module
• Power consumption in gassed and ungassed bioreactors
• Scale-up: effects of scale and scale-up strategies
• Oxygen mass transfer in bioreactors
• Case study: design of a bioreactor

Day 2
Case study: design of a bioreactor
• Tutorial: high throughput process development
• Bioreactor mixing
• Bioreactor scale-down: strategies and devices
• Expert lecture: the ambr™ advanced micro bioreactor system, for cell culture clone selection and early stage process development
• Case study: design of a bioreactor

Day 3
• Case study: design and analysis of fermentation processes at the microscale
• Case study: predictive scale-up based on microscale experiments
• Tutorial: scale-up from shake flasks to stirred bioreactors
• Microfluidic bioreactors
• Expert lecture: rapid fermentation process development - industrial perspective
• Module round-up and close

UCL Experts

Dr Frank Baganz - Module Leader
Prof Gary Lye
Dr Martina Micheletti
Dr Nicholas Szita

Invited Expert Speakers Include

FUJIFILM Diosynth Biotechnologies

A networking dinner will be held on the first evening.

For further information and bookings please contact:
E: mbi-training@ucl.ac.uk
T: +44 (0) 20 7679 9619 l +44 (0) 203 549 5619

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