Rapid Fermentation Process Design

Focusing on rapid fermentation process development and scale-up

Autumn 2015

This new module focuses on rapid fermentation process development and scale-up, through a series of lectures and case studies enabling you to:

  • Understand engineering principles of fermentation.
  • Determine power consumption and oxygen mass transfer.
  • Evaluate different strategies for scale-up and scale-down.
  • Know about miniaturised bioreactors and their role in fermentation process development.
  • Understand how to design a bioreactor and use data from microscale experiments for scaleup.

Who should attend?

Fermentation scientists and engineers in biotechnology and biopharmaceutical companies’ or similar who are involved in process transfer to manufacturers and also those in established fermentation development groups wishing to be kept up to date with the latest research in this area.


Day 1

• Introduction to module
• Power consumption in gassed and ungassed bioreactors
• Scale-up: effects of scale and scale-up strategies
• Oxygen mass transfer in bioreactors
• Case study: design of a bioreactor

Day 2

Case study: design of a bioreactor
• Tutorial: high throughput process development
• Bioreactor mixing
• Bioreactor scale-down: strategies and devices
• Expert lecture: the ambr™ advanced micro bioreactor system, for cell culture clone selection and early stage process development
• Case study: design of a bioreactor

Day 3

• Case study: design and analysis of fermentation processes at the microscale
• Case study: predictive scale-up based on microscale experiments
• Tutorial: scale-up from shake flasks to stirred bioreactors
• Microfluidic bioreactors
• Expert lecture: rapid fermentation process development - industrial perspective
• Module round-up and close

Teaching Staff

Dr Frank Baganz, UCL - Module Leader
Prof Gary Lye, UCL
Dr Martina Micheletti, UCL
Dr Nicholas Szita, UCL

Invited Expert Speakers

Angus Thompson, FUJIFILM Diosynth Biotechnologies UK Limited
Barney Zoro, TAP Biosystems
Tibor Anderlei, Adolf Kuhner AG

A networking dinner will be held on the first evening.

Module cost TBC.

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Page last modified on 26 mar 15 14:09