Current Challenges in Mammalian Cell Processing


Industrial platforms, Underpinning bioscience, Novel technologies characterisation

January 2017

Mammalian cells have become the workhorse of the biotech industry due to their ability to produce of functional complex macromolecules at scale. The new Whole Bioprocessing of Mammalian Cell Products MBI® module is a three day course designed specifically for the wide range of professions now working in this field.

The course gives delegates a unique insight into platform technologies developed by world leaders in the field such as Lonza Biologics, MedImmune and Life Technologies.  Delegates will be encouraged to consider mammalian cell culture processes as whole rather than individual operations in isolation. For example, talks will explore how upstream process development affects downstream processing, the challenges associated with product analysis, Quality by Design (QbD) and process economics.

Talks from internationally renowned academics will discuss the underpinning bioscience and novel technologies  currently in development to meet future demand.

There will also be the opportunity to interact with UCL’s extensive macromolecular research program ( with particular focus on our new and unique single-use facility. Talks, tours and networking opportunities are supplemented with an interactive industry led case study which puts delegates in a real-life process development scenario.

Who should attend?

The course is particularly useful given the highly inter-disciplinary nature of the field. Busy delegates from a wide variety of backgrounds will be given the opportunity to step  back and understand the history behind the current state of the art: robust, efficient and defined production processes. Molecular biologists, process engineers, cell biologists, analytical scientists, project managers and chief scientific  officers are just a few of the professionals that will benefit from the opportunity to shed light on many of the specialised approaches which have become embedded within the industry.


Day 1
• Historic perspective of mammalian cell culture
• Rapid cell line development
• The design of highly productive processes
• Fundamentals of large scale production

Day 2
• Case study: from development to production
• Removal of adventitious agents during downstream processing
• Challenges for MCC analytics
• System design and scale-up from pilot to commercial manufacture using stirred single-use bioreactors  in a hybrid facility

Day 3
• Scale-down approaches to bioprocess development
• UCL mammalian cell culture tour and discussion
• Operational and development strategies to optimise process economics
• Quality by design - tools and a roadmap for implementation
• The impact of upstream production on downstream processing
• How can fundamental cell biology contribute to mammalian cell bioprocessing


Dr Farlan Veraitch, UCL - Module Leader
Prof John Birch, Independent Consultant

Industrial Expert Speakers Include

FUJIFILM Diosynth Biotechnologies
Lonza Biologics
University of Kent

For further information and bookings please contact:
T: +44 (0) 20 7679 9619 l +44 (0) 203 549 5619

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Page last modified on 24 feb 16 15:18