UCL DEPARTMENT OF BIOCHEMICAL ENGINEERING

Biochemical Engineering

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Downstream Processing: From Cell to Column: Integrated Solutions for Rapid Bioprocessing of Biologics  - New

Learn how to select the best recovery options for your bioprocess

12-15 November 2012

This new module focuses on the early stages of recovery and, through a series of lectures, case studies and pilot plant practical sessions, will enable you to:

• Understand the principles of all the major recovery operations: Centrifugation, Membrane Systems, Filtration, Cell Disruption, Precipitation, Flocculation, Liquid Extraction.
• Compare these unit operations for suitability within the process and study them in our unique pilot plant.
• Learn to use Ultra Scale Down tool for prediction of large scale separation performance
• Understand the interaction among fermentation, recovery and purification and learn the integrated solutions for bio process development

Who should attend?

This module is designed for scientists and engineers involved in design, development and operation of primary recovery steps as well as associated steps in upstream and purification processes.

Programme

Monday 12 November
• Introduction to Module
• Principles of Precipitation and Design of Precipitation Reactors
• Centrifugation
• Ultra Scale Down Centrifugation
• Case Study: Design of Precipitation Reactor

Tuesday 13 November

• Pilot-plant Studies: Centrifugation
• Intracellular Product Release
• Filtration
• Microfiltration and Ultrafiltration
• Ultra Scale Down Microfiltration

Wednesday 14 November

• Pilot-plant Studies: Microfiltration
• Bioprocess Applications of Centrifuges
• From Lab Scale to Manufacturing: Microfiltration Technology for Product Recovery and Purification
• Use of Adsorptive Depth Filtration in Biopharmaceutical Manufacturing

Thursday 15 November

• Simulation Studies: The Role of Microfiltration in Whole Bioprocess Studies
• Cell Engineering to Ease Primary Recovery
• Use Flocculation to Remove Key Impurities to Prepare Feed Material for Purification
• Primary Recovery Process Development with an Integrated Approach
• Viral Product Recovery in Vaccine Processing

Teaching Staff

Yuhong Zhou - Module Leader
Mike Hoare, UCL
Eli Keshavarz-Moore, UCL
Nigel Titchener-Hooker, UCL
Darren Nesbeth, UCL

Previous Expert Speakers

Colin Day, Millipore
Klaus Mannweiler, Westfalia
Aloke Dey-Chowdhury, Pall Life Sciences

A networking dinner will be held on the first evening.

The module costs £1600, with a £100 discount if you register and pay before 1 October.

Download the Flyer

Book Now!

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